Saint Louis vs Loyola Chicago College Basketball Prediction, Odds, Picks, Best Bets for March 4

The Loyola Chicago Ramblers (7-22, 3-13 A-10) will attempt to stop a seven-game road slide when they take on the Saint Louis Billikens (26-3, 14-2 A-10) on March 4, 2026 at Chaifetz Arena.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Saint Louis vs. Loyola Chicago Game Info and Odds

• Game day: Wednesday, March 4, 2026
• Game time: 8 p.m. ET
• TV channel: CBS Sports Network
• Location: St. Louis, Missouri
• Arena: Chaifetz Arena

Saint Louis vs. Loyola Chicago Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Saint Louis win (98.5%)

Before placing a wager on Wednesday's Saint Louis-Loyola Chicago spread (Saint Louis -21.5) or total (155.5 points), read the betting insights and trends below.

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Saint Louis vs. Loyola Chicago: ATS Betting Stats and Trends

• Saint Louis has won 17 games against the spread this season, while failing to cover 11 times.
• Loyola Chicago is 9-20-0 ATS this year.
• Against the spread, the Billikens have fared better when playing at home, covering 13 times in 17 home games, and four times in nine road games.
• The Ramblers' winning percentage against the spread, both home and away, is .333. They are 5-10-0 ATS on their home court and 3-6-0 on the road.
• Saint Louis has covered the spread 10 times in 16 conference games.
• Loyola Chicago has seven wins against the spread in 16 A-10 games this year.

Saint Louis vs. Loyola Chicago: Moneyline Betting Stats

• Saint Louis has come away with 23 wins in the 26 contests it has been listed as the moneyline favorite in this season.
• The Billikens have not lost in four games this year when favored by -10000 or better on the moneyline.
• Loyola Chicago has gone 3-17 in games it was the underdog on the moneyline (winning 15% of those games).
• The Ramblers have not played a game this season with moneyline odds of +2500 or longer.
• The moneyline set for this matchup implies Saint Louis has a 99% chance of walking away with the win.

Saint Louis vs. Loyola Chicago Head-to-Head Comparison

• Offensively, Saint Louis was the 157th-ranked team in the nation (74.3 points per game) last year. Defensively, it was 152nd (71.3 points allowed per game).
• Saint Louis was 168th in the nation in rebounds per game (32.2) and 265th in rebounds allowed (32.4) last season.
• Last season Saint Louis was ranked 83rd in the country in assists with 14.9 per game.
• With 12.3 turnovers committed per game and 9.8 turnovers forced last year, Saint Louis was 288th and 317th in the country, respectively.
• Loyola Chicago ranked 189th in the country last year with 73.5 points per game. At the other end of the court, it ranked 81st with 69 points allowed per game.
• Last season Loyola Chicago averaged 31.8 rebounds per game (184th-ranked in college basketball) and ceded 29.4 rebounds per contest (65th-ranked).
• Last year Loyola Chicago ranked 39th in college basketball in assists, delivering 16 per game.
• Loyola Chicago committed 11.3 turnovers per game (201st-ranked in college basketball) this season, while forcing 11.1 turnovers per contest (197th-ranked).

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