Pirates vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 1:12 a.m.

The Pittsburgh Pirates will take on the San Francisco Giants in MLB action on Tuesday.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Giants Game Info

• Pittsburgh Pirates (67-71) vs. San Francisco Giants (57-81)
• Date: Tuesday, September 1, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and NBCS-BA

Pirates vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-162) | SF: (+136)
• Spread: PIT: -1.5 (+146) | SF: +1.5 (-176)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Pirates vs Giants Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 9-11, 3.79 ERA vs Logan Webb (Giants) - 8-8, 3.72 ERA

The Pirates will give the nod to Paul Skenes (9-11, 3.79 ERA), who is eyeing win No. 10 on the season, and the Giants will counter with Logan Webb (8-8, 3.72 ERA). Skenes and his team are 9-18-0 ATS this season when he starts. Skenes' team is 9-13 this season when he starts and they are the moneyline favorite. The Giants are 11-13-0 ATS in Webb's 24 starts that had a set spread. The Giants have been the underdog on the moneyline in nine of Webb's starts this season, and they went 2-7 in those games.

Pirates vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (61.3%)

Pirates vs Giants Moneyline

• The moneyline numbers for Pirates vs. Giants reveal Pittsburgh as the favorite (-162) and San Francisco as the underdog (+136) on the road.

Pirates vs Giants Spread

• The Giants are +1.5 on the spread (-176 to cover), and Pittsburgh is +146 to cover the runline.

Pirates vs Giants Over/Under

• The Pirates-Giants game on Sept. 1 has been given an over/under of 7.5 runs. The over is set at -104 and the under at -118.

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Pirates vs Giants Betting Trends

• The Pirates have come away with 39 wins in the 70 contests they have been listed as the favorites in this season.
• This season Pittsburgh has come away with a win five times in 13 chances when named as a favorite of at least -162 on the moneyline.
• The Pirates and their opponents have gone over in 73 of their 136 games with a total set by sportsbooks this season.
• The Pirates are 66-70-0 against the spread in their 136 games that had a posted line this season.
• The Giants are 33-57 in games they were listed as the moneyline underdog (winning 36.7% of those games).
• When it has played as a moneyline underdog with odds of +136 or longer, San Francisco has a 13-11 record (winning 54.2% of its games).
• The Giants have had an over/under set by bookmakers 135 times, and have combined with opponents to go over the total in 64 of those games (64-62-9).
• The Giants have a 64-71-0 record ATS this season.

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with an OBP of .369 this season while batting .262 with 79 walks and 89 runs scored. He has a slugging percentage of .421.
• Among all qualified hitters, he is 58th in batting average, his on-base percentage ranks 18th, and he is 69th in slugging.
• Reynolds has recorded at least one hit in two straight games. During his last five outings he is hitting .300 with a double and two walks.
• Brandon Lowe leads Pittsburgh in total hits (126) this season while batting .251 with 56 extra-base hits. He's slugging .476 with an on-base percentage of .320.
• He ranks 80th in batting average, 87th in on-base percentage and 28th in slugging among qualified hitters.
• Lowe brings a two-game streak with at least one hit into this contest. In his last five games he is hitting .214 with a double, a home run, four walks and two RBIs.
• Nick Gonzales has hit six homers with a team-high .396 SLG this season.
• Gonzales enters this game with two games in a row with at least one hit. During his last five outings he is batting .316 with a double, four walks and two RBIs.
• Oneil Cruz has 17 home runs, 52 RBI and a batting average of .263 this season.
• Cruz brings a three-game hitting streak into this matchup. In his last five games he is hitting .316 with a double, a home run, three walks and an RBI.

Giants Player Leaders

• Rafael Devers is leading the Giants with 131 hits. He's batting .252 and slugging .490 with an on-base percentage of .330.
• Including all qualified hitters in the majors, his batting average places him 79th, his on-base percentage is 74th, and he is 22nd in slugging.
• Devers hopes to build on an eight-game hitting streak in this matchup. During his last 10 games he is hitting .342 with a double, four home runs, six walks and nine RBIs.
• Jung Hoo Lee's .331 on-base percentage and .419 slugging percentage are both team-highs. He has a batting average of .288.
• He is 14th in batting average, 69th in on-base percentage and 72nd in slugging percentage in the majors.
• Bryce Eldridge has 17 doubles, 15 home runs and 47 walks while hitting .263.
• Drew Gilbert has 13 doubles, three triples, eight home runs and 33 walks while hitting .236.

Pirates vs Giants Head to Head

• 5/10/2026: 7-6 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/9/2026: 13-3 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/8/2026: 5-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/6/2025: 4-2 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/5/2025: 8-1 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/4/2025: 5-4 PIT (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/30/2025: 2-1 PIT (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/29/2025: 3-1 PIT (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/28/2025: 6-5 PIT (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/23/2024: 7-6 SF (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)

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