Padres vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 2:12 a.m.

The San Diego Padres versus the Cincinnati Reds is on the MLB schedule for Tuesday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Reds Game Info

• San Diego Padres (73-65) vs. Cincinnati Reds (65-73)
• Date: Tuesday, September 1, 2026
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and Padres.TV

Padres vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-134) | CIN: (+114)
• Spread: SD: -1.5 (+122) | CIN: +1.5 (-146)
• Total: 9.5 -- Over: (-106) | Under: (-114)

Padres vs Reds Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 10-6, 4.02 ERA vs Nick Lodolo (Reds) - 3-3, 5.24 ERA

The Padres will give the ball to Randy Vasquez (10-6, 4.02 ERA), who is eyeing win No. 11 on the season, and the Reds will counter with Nick Lodolo (3-3, 5.24 ERA). Vasquez and his team are 15-6-0 ATS this season when he starts. Vasquez's team has been victorious in 77.8% of the games he's started as the moneyline favorite with a record of 7-2. The Reds have a 6-10-0 record against the spread in Lodolo's starts. The Reds have a 5-6 record in Lodolo's 11 starts this season when they were the moneyline underdog.

Padres vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.7%)

Padres vs Reds Moneyline

• The Padres vs Reds moneyline has San Diego as a -134 favorite, while Cincinnati is a +114 underdog at home.

Padres vs Reds Spread

• The Reds are hosting the Padres, and are +1.5 on the runline. The Reds are +122 to cover the spread, and the Padres are -146.

Padres vs Reds Over/Under

• Padres versus Reds, on Sept. 1, has an over/under of 9.5, with the over being -106 and the under -114.

Bet on San Diego Padres vs. Cincinnati Reds on FanDuel today!

Padres vs Reds Betting Trends

• The Padres have won in 35, or 57.4%, of the 61 contests they have been named as odds-on favorites in this year.
• San Diego has a record of 19-10 in contests when sportsbooks favor them by -134 or more on the moneyline.
• The Padres and their opponents have gone over in 61 of their 138 games with a total set by sportsbooks this season.
• In 138 games with a line this season, the Padres have a mark of 81-57-0 against the spread.
• The Reds have been the underdog on the moneyline 91 total times this season. They've finished 43-48 in those games.
• Cincinnati has a 21-28 record (winning 42.9% of its games) when it has played as a moneyline underdog of +114 or longer.
• The Reds have played in 135 games with a set over/under, and have combined with their opponents to go over the total 72 times (72-61-2).
• The Reds have a 69-66-0 record against the spread this season (covering 51.1% of the time).

Padres Player Leaders

• Fernando Tatis Jr. has 150 hits and an OBP of .349 to go with a slugging percentage of .438. All three of those stats are tops among San Diego hitters this season. He has a .281 batting average, as well.
• Among qualified batters in baseball, he is 24th in batting average, 42nd in on-base percentage, and 53rd in slugging.
• Manny Machado has 21 doubles, 24 home runs and 65 walks. He's batting .220 and slugging .405 with an on-base percentage of .307.
• Among all qualifying players, he is 125th in batting average, 108th in on-base percentage and 87th in slugging percentage.
• Machado has picked up a hit in three straight games. In his last five games he is batting .381 with a double, two walks and two RBIs.
• Jackson Merrill has collected 126 base hits, an OBP of .294 and a slugging percentage of .419 this season.
• Merrill has recorded a hit in two straight games. During his last five outings he is batting .368 with a double, a triple, a home run, three walks and four RBIs.
• Xander Bogaerts has 11 home runs, 51 RBI and a batting average of .217 this season.
• Bogaerts brings a two-game hitting streak into this game. In his last five games he is batting .176 with a double, a walk and four RBIs.

Reds Player Leaders

• Sal Stewart has 141 hits with a .489 slugging percentage, both team-best numbers for the Reds. He's batting .266 and with an on-base percentage of .337.
• Including all qualifying players in the majors, he is 51st in batting average, 62nd in on-base percentage and 23rd in slugging percentage.
• Stewart brings a four-game hitting streak into this matchup. In his last five games he is batting .350 with a double, three home runs, two walks and six RBIs.
• Elly De La Cruz's .351 OBP leads his team. He has a batting average of .270 while slugging .477.
• Including all qualifying players, his batting average puts him 45th, his on-base percentage is 40th, and he is 26th in slugging.
• JJ Bleday is hitting .216 with 14 doubles, two triples, 21 home runs and 64 walks.
• Tyler Stephenson is batting .251 with 19 doubles, 14 home runs and 41 walks.

Padres vs Reds Head to Head

• 8/31/2026: 5-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +134)
• 6/10/2026: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/9/2026: 5-3 CIN (Favorite: Reds, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/8/2026: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 2-1 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/9/2025: 4-2 CIN (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/8/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/29/2025: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/28/2025: 6-4 SD (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/27/2025: 8-1 CIN (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)

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