Pirates vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 11:12 p.m.

In MLB action on Sunday, the Pittsburgh Pirates play the San Francisco Giants.

We've got you covered, in terms of the vital info regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Giants Game Info

• Pittsburgh Pirates (21-18) vs. San Francisco Giants (15-23)
• Date: Sunday, May 10, 2026
• Time: 4:05 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and SportsNet PT

Pirates vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-110) | SF: (-106)
• Spread: PIT: -1.5 (+158) | SF: +1.5 (-192)
• Total: 7 -- Over: (-122) | Under: (+100)

Pirates vs Giants Probable Starting Pitchers

Probable Pitchers: Bubba Chandler (Pirates) - 1-4, 4.76 ERA vs Tyler Mahle (Giants) - 1-4, 5.00 ERA

The probable pitchers are Bubba Chandler (1-4) for the Pirates and Tyler Mahle (1-4) for the Giants. Chandler's team is 3-4-0 against the spread in his starts this season. Chandler's team has a record of 2-2 this season when he starts and they are the favorite on the moneyline. When Mahle starts, the Giants have gone 3-4-0 against the spread. The Giants have been the moneyline underdog in six of Mahle's starts this season, and they went 2-4 in those games.

Pirates vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (50.4%)

Pirates vs Giants Moneyline

• Looking at the moneyline for Pirates-Giants, Pittsburgh is the favorite at -110, and San Francisco is -106 playing at home.

Pirates vs Giants Spread

• The Giants are at +1.5 on the runline against the Pirates. The Giants are -192 to cover the spread, and the Pirates are +158.

Pirates vs Giants Over/Under

• An over/under of 7 has been set for Pirates-Giants on May 10, with the over being -122 and the under +100.

Bet on Pittsburgh Pirates vs. San Francisco Giants on FanDuel today!

Pirates vs Giants Betting Trends

• The Pirates have been victorious in 14, or 63.6%, of the 22 contests they have been chosen as favorites in this season.
• Pittsburgh has a record of 14-8 in contests when sportsbooks favor them by -110 or more on the moneyline.
• The Pirates and their opponents have hit the over in 19 of their 38 games with a total set by oddsmakers this season.
• The Pirates are 19-19-0 against the spread in their 38 games that had a posted line this season.
• The Giants have won nine of the 25 games they were listed as the moneyline underdog this season (36%).
• San Francisco has a record of 9-14 when playing as a moneyline underdog with odds of -106 or longer (39.1%).
• In the 38 games bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 15 times (15-20-3).
• The Giants have collected a 16-22-0 record ATS this season (covering 42.1% of the time).

Pirates Player Leaders

• Brandon Lowe leads Pittsburgh in total hits (33) this season while batting .262 with 18 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .563.
• Among qualified hitters in baseball, he ranks 68th in batting average, 48th in on-base percentage, and 11th in slugging.
• Bryan Reynolds leads Pittsburgh in OBP (.395) this season, fueled by 34 hits. He's batting .248 while slugging .401.
• Among all qualifying hitters, he is 90th in batting average, 14th in on-base percentage and 88th in slugging percentage.
• Oneil Cruz has hit nine homers with a team-high .461 SLG this season.
• Ryan O'Hearn leads Pittsburgh in slugging percentage (.443) thanks to 10 extra-base hits.

Giants Player Leaders

• Luis Arraez has put up a team-high .394 slugging percentage. He's batting .314 with an on-base percentage of .338.
• Including all the qualified hitters in the big leagues, he is 14th in batting average, 82nd in on-base percentage and 97th in slugging percentage.
• Casey Schmitt leads his team with 35 hits and a .341 on-base percentage. He has a batting average of .294 while slugging .529.
• Including all qualifying hitters, he ranks 30th in batting average, 78th in on-base percentage and 20th in slugging percentage.
• Jung Hoo Lee is hitting .270 with eight doubles, a triple, two home runs and 10 walks.
• Matt Chapman has six doubles, a triple, a home run and 14 walks while batting .227.

Pirates vs Giants Head to Head

• 5/8/2026: 5-2 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/6/2025: 4-2 SF (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/5/2025: 8-1 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/4/2025: 5-4 PIT (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/30/2025: 2-1 PIT (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/29/2025: 3-1 PIT (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/28/2025: 6-5 PIT (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/23/2024: 7-6 SF (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/22/2024: 9-5 SF (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/21/2024: 7-6 PIT (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!