Pirates vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 8:11 p.m.

MLB action on Thursday includes the Pittsburgh Pirates playing the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Cardinals Game Info

• Pittsburgh Pirates (80-77) vs. St. Louis Cardinals (76-81)
• Date: Thursday, September 24, 2026
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Cardinals.TV

Pirates vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-162) | STL: (+136)
• Spread: PIT: -1.5 (+158) | STL: +1.5 (-192)
• Total: 6.5 -- Over: (-132) | Under: (+108)

Pirates vs Cardinals Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 10-11, 3.91 ERA vs Kyle Leahy (Cardinals) - 10-5, 3.65 ERA

This contest's pitching matchup is set, as the Pirates will send Paul Skenes (10-11) to the mound, while Kyle Leahy (10-5) will get the nod for the Cardinals. Skenes' team is 11-20-0 against the spread this season in his starts. When Skenes starts a game and his team is the favorite on the moneyline, they have a record of 12-13. The Cardinals have gone 13-14-0 ATS in Leahy's 27 starts with a set spread. The Cardinals have been the underdog on the moneyline in 16 of Leahy's starts this season, and they went 6-10 in those matchups.

Pirates vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (65.2%)

Pirates vs Cardinals Moneyline

• St. Louis is a +136 underdog on the moneyline, while Pittsburgh is a -162 favorite at home.

Pirates vs Cardinals Spread

• The Pirates are 1.5-run home favorites on the runline against the Cardinals. The Pirates are +158 to cover, and the Cardinals are -192.

Pirates vs Cardinals Over/Under

• The Pirates-Cardinals contest on Sept. 24 has been given an over/under of 6.5 runs. The over is set at -132 and the under at +108.

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Pirates vs Cardinals Betting Trends

• The Pirates have been favorites in 80 games this season and have come away with the win 47 times (58.8%) in those contests.
• This year Pittsburgh has won 11 of 20 games when listed as at least -162 on the moneyline.
• The Pirates' games have gone over the total in 81 of their 155 opportunities.
• In 155 games with a line this season, the Pirates have a mark of 78-77-0 against the spread.
• The Cardinals have won 45.9% of the games this season they were the moneyline underdog (45-53).
• St. Louis has a record of 12-15 when playing as a moneyline underdog with odds of +136 or longer (44.4%).
• In the 153 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 71 times (71-75-7).
• The Cardinals have collected an 81-72-0 record against the spread this season (covering 52.9% of the time).

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with an OBP of .365 this season while batting .262 with 85 walks and 101 runs scored. He has a slugging percentage of .425.
• He ranks 57th in batting average, 21st in on-base percentage, and 68th in slugging among qualifying hitters in MLB.
• Reynolds has hit safely in two games in a row. In his last five games he is batting .263 with four doubles and a walk.
• Brandon Lowe leads Pittsburgh in total hits (148) this season while batting .260 with 63 extra-base hits. He's slugging .489 with an on-base percentage of .330.
• Among qualified hitters, his batting average places him 65th, his on-base percentage 71st, and his slugging percentage 18th.
• Nick Gonzales has a team-best OPS of .754, fueled by a slash line of .302/.365/.389 this season.
• Ryan O'Hearn has been key for Pittsburgh with 103 hits, an OBP of .330 plus a slugging percentage of .441.
• O'Hearn brings a two-game hitting streak into this game. In his last five games he is batting .222 with two walks and two RBIs.

Cardinals Player Leaders

• Alec Burleson has a .463 slugging percentage, which paces the Cardinals. He's batting .280 with an on-base percentage of .345.
• Including all the qualifying hitters in the majors, his batting average puts him 23rd, his on-base percentage ranks 49th, and he is 36th in slugging.
• Jordan Walker has 161 hits to lead his team. He has a batting average of .273 while slugging .471 with an on-base percentage of .331.
• He ranks 36th in batting average, 68th in on-base percentage and 29th in slugging percentage in the big leagues.
• Ivan Herrera has accumulated an on-base percentage of .356, a team-high for the Cardinals.
• JJ Wetherholt is batting .240 with 14 doubles, 17 home runs and 63 walks.

Pirates vs Cardinals Head to Head

• 9/22/2026: 2-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/30/2026: 5-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/29/2026: 6-2 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/28/2026: 4-1 STL (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: +104)
• 5/21/2026: 6-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/20/2026: 7-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/19/2026: 9-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)

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