Pirates vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 2:12 a.m.

The Wednesday slate in MLB includes a matchup between the Pittsburgh Pirates and the Milwaukee Brewers.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Pirates vs Brewers Game Info

• Pittsburgh Pirates (32-49) vs. Milwaukee Brewers (44-36)
• Date: Wednesday, June 25, 2025
• Time: 2:10 p.m. ET
• Venue: American Family Field -- Milwaukee, Wisconsin
• Coverage: MLB Network, FDSWI, and SportsNet PT

Pirates vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-120) | MIL: (+102)
• Spread: PIT: -1.5 (+152) | MIL: +1.5 (-184)
• Total: 6.5 -- Over: (-114) | Under: (-106)

Pirates vs Brewers Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 4-6, 1.85 ERA vs Jacob Misiorowski (Brewers) - 2-0, 1.64 ERA

The Pirates will call on Paul Skenes (4-6) against the Brewers and Jacob Misiorowski (2-0). Skenes and his team have a record of 7-9-0 against the spread when he starts. Skenes' team has been victorious in 45.5% of the games he's started as the moneyline favorite with a record of 5-6. Misiorowski has started two games with set spreads, and the Brewers covered in both chances. The Brewers were the moneyline underdog for two Misiorowski starts this season -- they won both.

Pirates vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (51.4%)

Pirates vs Brewers Moneyline

• Milwaukee is a +102 underdog on the moneyline, while Pittsburgh is a -120 favorite on the road.

Pirates vs Brewers Spread

• The Pirates are favored by 1.5 runs on the road against the Brewers. The Pirates are +152 to cover the spread, while the Brewers are -184.

Pirates vs Brewers Over/Under

• A combined run total of 6.5 has been set for Pirates-Brewers on June 25, with the over at -114 and the under at -106.

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Pirates vs Brewers Betting Trends

• The Pirates have come away with 10 wins in the 21 contests they have been listed as the favorites in this season.
• Pittsburgh has a record of 6-8 in contests when sportsbooks favor them by -120 or more on the moneyline.
• The Pirates and their opponents have hit the over in 29 of their 75 games with a total set by oddsmakers this season.
• In 75 games with a line this season, the Pirates have a mark of 37-38-0 against the spread.
• The Brewers are 17-23 in games they were listed as the moneyline underdog (winning 42.5% of those games).
• Milwaukee has a record of 12-20 when it has played as a moneyline underdog with odds of +102 or longer (37.5%).
• In the 79 games oddsmakers have set an over/under for the Brewers, they have combined with opponents to go over the total 33 times (33-45-1).
• The Brewers have covered 51.9% of their games this season, going 41-38-0 against the spread.

Pirates Player Leaders

• Oneil Cruz has 10 doubles, a triple, 13 home runs and 42 walks while hitting .208. He has an on-base percentage of .321 and a slugging percentage of .404.
• Among qualifying hitters in baseball, his batting average ranks 154th, his on-base percentage ranks 98th, and he is 102nd in slugging.
• Andrew McCutchen has 65 hits and an OBP of .338, both of which lead the Pirates this season. He's batting .259 and slugging .406.
• He is 77th in batting average, 67th in on-base percentage and 101st in slugging in the major leagues.
• Bryan Reynolds has an OPS of .677, fueled by an OBP of .304 and a team-best slugging percentage of .373 this season.
• Reynolds enters this game with three games in a row with at least one hit. During his last five outings he is hitting .389 with three doubles and a walk.
• Isiah Kiner-Falefa has one home run, 18 RBI and a batting average of .276 this season.
• Kiner-Falefa enters this game on a two-game hitting streak. During his last five outings he is hitting .125 with a triple, a walk and an RBI.

Brewers Player Leaders

• Jackson Chourio has a .445 slugging percentage, which leads the Brewers. He's batting .257 with an on-base percentage of .287.
• Including all the qualifying hitters in the majors, his batting average is 79th, his on-base percentage ranks 143rd, and he is 60th in slugging.
• Christian Yelich paces his team with 75 hits. He has a batting average of .264 while slugging .458 with an on-base percentage of .344.
• Including all qualified players, he ranks 66th in batting average, 58th in on-base percentage and 55th in slugging percentage.
• Sal Frelick is hitting .295 with nine doubles, three triples, four home runs and 21 walks.
• Brice Turang is batting .277 with 11 doubles, five home runs and 35 walks.

Pirates vs Brewers Head to Head

• 6/24/2025: 9-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 6/23/2025: 5-4 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 5/25/2025: 6-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 5/24/2025: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/23/2025: 6-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 5/22/2025: 8-5 MIL (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/26/2024: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/25/2024: 2-1 PIT (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 9/24/2024: 7-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/11/2024: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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