Phillies vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 7:11 a.m.

The MLB schedule on Wednesday includes the Philadelphia Phillies facing the Houston Astros.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Phillies vs Astros Game Info

• Philadelphia Phillies (47-32) vs. Houston Astros (46-33)
• Date: Wednesday, June 25, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and NBCS-PH

Phillies vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-158) | HOU: (+134)
• Spread: PHI: -1.5 (+104) | HOU: +1.5 (-125)
• Total: 7.5 -- Over: (-106) | Under: (-114)

Phillies vs Astros Probable Starting Pitchers

Probable Pitchers: Zack Wheeler (Phillies) - 7-2, 2.61 ERA vs Colton Gordon (Astros) - 2-1, 4.54 ERA

This contest's pitching matchup is set, as the Phillies will send Zack Wheeler (7-2) to the mound, while Colton Gordon (2-1) will answer the bell for the Astros. Wheeler's team is 8-7-0 against the spread in his starts this season. Wheeler's team has been victorious in 84.6% of the games he's started as the moneyline favorite with a record of 11-2. The Astros have a 4-3-0 ATS record in Gordon's seven starts that had a set spread. The Astros were the moneyline underdog for three Gordon starts this season -- they won every game.

Phillies vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (52.2%)

Phillies vs Astros Moneyline

• The moneyline numbers for Phillies vs. Astros reveal Philadelphia as the favorite (-158) and Houston as the underdog (+134) despite being the home team.

Phillies vs Astros Spread

• The Phillies are 1.5-run road favorites on the runline against the Astros. The Phillies are +104 to cover, and the Astros are -125.

Phillies vs Astros Over/Under

• Phillies versus Astros, on June 25, has an over/under of 7.5, with the over being -106 and the under -114.

Bet on Philadelphia Phillies vs. Houston Astros on FanDuel today!

Phillies vs Astros Betting Trends

• The Phillies have been chosen as favorites in 61 games this year and have walked away with the win 41 times (67.2%) in those games.
• This year Philadelphia has won 25 of 32 games when listed as at least -158 on the moneyline.
• Contests with the Phillies have gone over the total set by bookmakers in 31 of 75 chances this season.
• In 75 games with a line this season, the Phillies have a mark of 38-37-0 against the spread.
• The Astros have won 56.5% of the games this season they were the underdog on the moneyline (13-10).
• Houston has played as a moneyline underdog of +134 or longer in only two games this season, which it won both.
• In the 78 games bookmakers have set an over/under for the Astros, they have combined with opponents to go over the total 31 times (31-45-2).
• The Astros have a 40-38-0 record ATS this season.

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia in OBP (.378) and total hits (71) this season. He's batting .247 batting average while slugging .535.
• Among all qualified batters in baseball, he is 102nd in batting average, 18th in on-base percentage, and 13th in slugging.
• Trea Turner has an OPS of .803, fueled by an OBP of .355 and a team-best slugging percentage of .448 this season. He's batting .300.
• He ranks 18th in batting average, 39th in on-base percentage and 57th in slugging in the major leagues.
• Turner has picked up at least one hit in two games in a row. In his last five games he is batting .238 with a double and an RBI.
• Nick Castellanos is batting .285 with a .443 slugging percentage and 41 RBI this year.
• Castellanos heads into this game with four games in a row with at least one hit. During his last five outings he is hitting .350 with three doubles, a home run, a walk and five RBIs.
• Alec Bohm has been key for Philadelphia with 85 hits, an OBP of .327 plus a slugging percentage of .402.

Astros Player Leaders

• Jeremy Pena has accumulated 100 hits with a .382 on-base percentage and a .495 slugging percentage, all club-highs for the Astros. He's batting .326.
• He ranks fifth in batting average, 16th in on-base percentage and 25th in slugging percentage among all qualifying hitters in the big leagues.
• Isaac Paredes is hitting .254 with 10 doubles, a triple, 16 home runs and 42 walks. He's slugging .471 with an on-base percentage of .360.
• He is 90th in batting average, 33rd in on-base percentage and 40th in slugging percentage in the big leagues.
• Jose Altuve is hitting .266 with 10 doubles, 12 home runs and 25 walks.
• Jake Meyers is batting .307 with 13 doubles, a triple, three home runs and 23 walks.

Phillies vs Astros Head to Head

• 6/24/2025: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/28/2024: 10-0 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/27/2024: 5-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 3-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 4/30/2023: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/29/2023: 6-1 PHI (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/28/2023: 3-1 PHI (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 11/5/2022: 4-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 11/3/2022: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 11/2/2022: 5-0 HOU (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!