Cubs vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 7:11 a.m.

The MLB's Wednesday schedule includes the Chicago Cubs taking on the St. Louis Cardinals.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Cardinals Game Info

• Chicago Cubs (46-33) vs. St. Louis Cardinals (44-36)
• Date: Wednesday, June 25, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and MARQ

Cubs vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-136) | STL: (+116)
• Spread: CHC: -1.5 (+126) | STL: +1.5 (-152)
• Total: 9 -- Over: (-100) | Under: (-122)

Cubs vs Cardinals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 6-3, 2.84 ERA vs Erick Fedde (Cardinals) - 3-6, 3.54 ERA

The probable pitchers are Matthew Boyd (6-3) for the Cubs and Erick Fedde (3-6) for the Cardinals. Boyd's team is 5-10-0 against the spread this season in his starts. Boyd's team has been victorious in 70% of the games he's started as the moneyline favorite with a record of 7-3. The Cardinals have an 8-7-0 ATS record in Fedde's 15 starts with a set spread. The Cardinals have a 3-7 record in Fedde's 10 starts this season when they were the underdog on the moneyline.

Cubs vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (50.6%)

Cubs vs Cardinals Moneyline

• Chicago is a -136 favorite on the moneyline, while St. Louis is a +116 underdog at home.

Cubs vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Cubs. The Cardinals are -152 to cover, and the Cubs are +126.

Cubs vs Cardinals Over/Under

• A total of 9 runs has been set for the Cubs-Cardinals contest on June 25, with the over available at -100 and the under at -122.

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Cubs vs Cardinals Betting Trends

• The Cubs have won in 35, or 68.6%, of the 51 contests they have been named as odds-on favorites in this year.
• This season Chicago has come away with a win 25 times in 35 chances when named as a favorite of at least -136 on the moneyline.
• The Cubs and their opponents have gone over in 42 of their 77 games with a total set by sportsbooks this season.
• The Cubs are 38-39-0 against the spread in their 77 games that had a posted line this season.
• The Cardinals have gone 24-20 in games they were the underdog on the moneyline (winning 54.5% of those games).
• When playing as a moneyline underdog with odds of +116 or longer, St. Louis has a record of 9-10 (47.4%).
• The Cardinals have had an over/under set by bookmakers 80 times, and have combined with opponents to go over the total in 43 of those games (43-34-3).
• The Cardinals have a 44-36-0 record against the spread this season (covering 55% of the time).

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.397) this season, fueled by 84 hits. He has a .288 batting average and a slugging percentage of .524.
• He is 27th in batting average, fifth in on-base percentage, and 14th in slugging among qualified batters in the majors.
• Pete Crow-Armstrong leads Chicago with 83 hits. He is batting .273 this season and has 43 extra-base hits. He's also slugging .563 with an on-base percentage of .310.
• He is 52nd in batting average, 117th in on-base percentage and sixth in slugging among qualifying batters.
• Crow-Armstrong brings a four-game streak with at least one hit into this matchup. In his last five games he is hitting .316 with three doubles, a home run and an RBI.
• Seiya Suzuki has collected 79 base hits, an OBP of .315 and a slugging percentage of .546 this season.
• Suzuki has recorded at least one base hit in three straight games. During his last five outings he is batting .333 with a double, three home runs, a walk and six RBIs.
• Nico Hoerner leads Chicago in slugging percentage (.370) thanks to 19 extra-base hits.
• Hoerner takes a three-game hitting streak into this matchup. During his last five outings he is hitting .389 with a home run and three RBIs.

Cardinals Player Leaders

• Brendan Donovan has an on-base percentage of .377 and a slugging percentage of .438. Both lead the Cardinals. He's batting .310.
• Including all qualified hitters in the majors, his batting average places him ninth, his on-base percentage is 19th, and he is 68th in slugging.
• Nolan Arenado is hitting .247 with 11 doubles, a triple, 10 home runs and 23 walks. He's slugging .399 with an on-base percentage of .309.
• Including all qualified hitters, he ranks 102nd in batting average, 120th in on-base percentage and 109th in slugging percentage.
• Lars Nootbaar is hitting .230 with 13 doubles, 11 home runs and 44 walks.
• Willson Contreras is hitting .248 with 18 doubles, 10 home runs and 25 walks.

Cubs vs Cardinals Head to Head

• 6/24/2025: 8-7 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/23/2025: 8-2 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/4/2024: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/3/2024: 5-4 STL (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/2/2024: 6-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/1/2024: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/14/2024: 8-3 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/13/2024: 5-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/13/2024: 11-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/12/2024: 5-1 CHC (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -196, Underdog Moneyline: +164)

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