Padres vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 6:14 p.m.

On Saturday in MLB, the San Diego Padres are playing the Chicago White Sox.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs White Sox Game Info

• San Diego Padres (88-66) vs. Chicago White Sox (36-118)
• Date: Saturday, September 21, 2024
• Time: 8:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: NBCS-CHI

Padres vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-320) | CHW: (+260)
• Spread: SD: -1.5 (-142) | CHW: +1.5 (+118)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Padres vs White Sox Probable Starting Pitchers

Probable Pitchers: Martín Pérez (Padres) - 4-5, 4.36 ERA vs Chris Flexen (White Sox) - 2-14, 5.09 ERA

The Padres will give the nod to Martin Perez (4-5, 4.36 ERA), who is eyeing win No. 5 on the season, and the White Sox will turn to Chris Flexen (2-14, 5.09 ERA). Pérez's team is 11-12-0 against the spread in his starts this season. Perez's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 5-5. The White Sox have a 7-21-0 record against the spread in Flexen's starts. The White Sox have been the underdog on the moneyline in 28 of Flexen's starts this season, and they went 4-24 in those games.

Padres vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (64.8%)

Padres vs White Sox Moneyline

• Chicago is the underdog, +260 on the moneyline, while San Diego is a -320 favorite at home.

Padres vs White Sox Spread

• The White Sox are +1.5 on the spread (+118 to cover), and San Diego is -142 to cover the runline.

Padres vs White Sox Over/Under

• The over/under for the Padres versus White Sox contest on Sept. 21 has been set at 7.5, with -115 odds on the over and -105 odds on the under.

Bet on San Diego Padres vs. Chicago White Sox on FanDuel today!

Padres vs White Sox Betting Trends

• The Padres have come away with 55 wins in the 96 contests they have been listed as the favorites in this season.
• San Diego has not played a game this season with better moneyline odds than -320.
• The Padres and their opponents have gone over the total this season in 80 of their 152 opportunities.
• The Padres are 76-76-0 against the spread in their 152 games that had a posted line this season.
• The White Sox have won 20.6% of the games this season they were the moneyline underdog (29-112).
• When playing as a moneyline underdog with odds of +260 or longer, Chicago has a record of 2-5 (28.6%).
• The White Sox have played in 149 games with a set over/under, and have combined with opponents to go over the total 66 times (66-78-5).
• The White Sox are 60-89-0 against the spread this season.

Padres Player Leaders

• Jurickson Profar leads San Diego in OBP (.384) this season, fueled by 152 hits. He has a .283 batting average and a slugging percentage of .461.
• He ranks 21st in batting average, sixth in on-base percentage, and 39th in slugging among all qualifying hitters in the majors.
• Manny Machado is batting .279 with 29 doubles, 29 home runs and 42 walks, while slugging .484 with an on-base percentage of .328.
• Among qualifying hitters, his batting average places him 26th, his on-base percentage 59th, and his slugging percentage 22nd.
• Machado brings a four-game streak with at least one hit into this one. During his last five outings he is hitting .350 with a double, three home runs and six RBI.
• Jackson Merrill leads San Diego with 155 hits. He is batting .292 this season and 59 of his hits have gone for extra bases.
• Merrill has recorded a hit in two straight games. In his last five games he is batting .333 with two doubles, a home run, two walks and three RBI.
• Luis Arraez leads San Diego with a slugging percentage of .390, fueled by 34 extra-base hits.

White Sox Player Leaders

• Andrew Vaughn has put up a slugging percentage of .413 and has 133 hits, both team-high figures for the White Sox. He's batting .247 and with an on-base percentage of .299.
• Including all qualified hitters in MLB, his batting average places him 79th, his on-base percentage ranks 112th, and he is 77th in slugging.
• Vaughn hopes to build on a six-game hitting streak in this matchup. In his last 10 outings he is hitting .333 with two doubles, a triple, two home runs, a walk and five RBI.
• Andrew Benintendi has 19 doubles, 19 home runs and 41 walks while batting .226. He's slugging .393 with an on-base percentage of .289.
• He is 119th in batting average, 121st in on-base percentage and 98th in slugging percentage in the big leagues.
• Gavin Sheets a has .308 on-base percentage to pace the White Sox.
• Nicky Lopez is batting .243 with 12 doubles, three triples, a home run and 37 walks.

Padres vs White Sox Head to Head

• 9/20/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -295, Underdog Moneyline: +240)
• 10/1/2023: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/30/2023: 6-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/29/2023: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 10/2/2022: 2-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2022: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/30/2022: 3-1 CHW (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -230, Underdog Moneyline: +190)

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