Cardinals vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 5:13 p.m.

The St. Louis Cardinals will face the Cleveland Guardians in MLB action on Saturday.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Guardians Game Info

• St. Louis Cardinals (77-77) vs. Cleveland Guardians (90-65)
• Date: Saturday, September 21, 2024
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: BSGL

Cardinals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | CLE: (-102)
• Spread: STL: +1.5 (-182) | CLE: -1.5 (+150)
• Total: 8 -- Over: (-118) | Under: (-104)

Cardinals vs Guardians Probable Starting Pitchers

Probable Pitchers: Miles Mikolas (Cardinals) - 8-11, 5.49 ERA vs Matthew Boyd (Guardians) - 2-1, 2.52 ERA

This contest's pitching matchup is set, as the Cardinals will send Miles Mikolas (8-11) to the mound, while Matthew Boyd (2-1) will get the nod for the Guardians. When Mikolas starts, his team is 16-14-0 against the spread this season. Mikolas' team is 2-6 this season when he starts and they are the moneyline favorite. The Guardians are 5-2-0 against the spread when Boyd starts. The Guardians won each of Boyd's three starts this season that they were the moneyline underdog.

Cardinals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.9%)

Cardinals vs Guardians Moneyline

• St. Louis is a -116 favorite on the moneyline, while Cleveland is a -102 underdog on the road.

Cardinals vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Cardinals. The Guardians are +150 to cover, while the Cardinals are -182 to cover as a 1.5-run underdog on the runline.

Cardinals vs Guardians Over/Under

• An over/under of 8 has been set for Cardinals-Guardians on Sept. 21, with the over being -118 and the under -104.

Bet on St. Louis Cardinals vs. Cleveland Guardians on FanDuel today!

Cardinals vs Guardians Betting Trends

• The Cardinals have come away with 33 wins in the 68 contests they have been listed as the favorites in this season.
• This year St. Louis has won 30 of 61 games when listed as at least -116 on the moneyline.
• The Cardinals and their opponents have hit the over in 68 of their 149 games with a total set by oddsmakers this season.
• The Cardinals have posted a record of 71-78-0 against the spread this season.
• The Guardians have won 26 of the 57 games they were listed as the moneyline underdog this season (45.6%).
• When it has played as a moneyline underdog with odds of -102 or longer, Cleveland has an 18-27 record (winning 40% of its games).
• The Guardians have played in 153 games with an over/under set, and have combined with opponents to go over the total 69 times (69-76-8).
• The Guardians have covered 53.6% of their games this season, going 82-71-0 against the spread.

Cardinals Player Leaders

• Brendan Donovan leads St. Louis OPS (.753) this season. He has a .275 batting average, an on-base percentage of .341, and a slugging percentage of .412.
• Among qualifying batters, he is 31st in batting average, his on-base percentage ranks 39th, and he is 79th in slugging.
• Alec Burleson has 141 hits, which ranks first among St. Louis batters this season. He's batting .269 with 41 extra-base hits. He's also slugging .427 with an on-base percentage of .313.
• His batting average ranks 39th among qualified players, his on-base percentage 94th, and his slugging percentage 67th.
• Nolan Arenado is batting .268 with a .393 slugging percentage and 69 RBI this year.
• Masyn Winn is batting .267 with a .313 OBP and 51 RBI for St. Louis this season.

Guardians Player Leaders

• Jose Ramirez has put up a team-best slugging percentage (.517) while pacing the Guardians in hits (164). He's batting .274 and with an on-base percentage of .332.
• Including all the qualified hitters in the big leagues, his batting average is 33rd, his on-base percentage is 49th, and he is 12th in slugging.
• Josh Naylor is batting .243 with 26 doubles, 31 home runs and 56 walks. He's slugging .462 with an on-base percentage of .320.
• Including all qualified hitters, his batting average places him 97th, his on-base percentage is 78th, and he is 38th in slugging.
• Andres Gimenez is batting .253 with 21 doubles, a triple, nine home runs and 26 walks.
• Lane Thomas is hitting .241 with 26 doubles, three triples, 14 home runs and 43 walks.

Cardinals vs Guardians Head to Head

• 9/20/2024: 5-1 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/28/2023: 4-3 CLE (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/27/2023: 2-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/26/2023: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)

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