Padres vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 2

Odds updated as of 12:11 p.m.

In MLB action on Friday, the San Diego Padres take on the Pittsburgh Pirates.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Pirates Game Info

• San Diego Padres (19-11) vs. Pittsburgh Pirates (12-20)
• Date: Friday, May 2, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: Apple TV+

Padres vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-162) | PIT: (+136)
• Spread: SD: -1.5 (+106) | PIT: +1.5 (-128)
• Total: 7.5 -- Over: (-122) | Under: (-100)

Padres vs Pirates Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 1-2, 5.76 ERA vs Mitch Keller (Pirates) - 1-2, 3.97 ERA

The Padres will look to Dylan Cease (1-2) versus the Pirates and Mitch Keller (1-2). Cease's team is 2-4-0 against the spread in his starts this season. When Cease starts a game and his team is the favorite on the moneyline, they have a record of 3-2. The Pirates have a 2-4-0 ATS record in Keller's six starts that had a set spread. The Pirates have a 1-2 record in Keller's three starts this season when they were the underdog on the moneyline.

Padres vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.1%)

Padres vs Pirates Moneyline

• Pittsburgh is the underdog, +136 on the moneyline, while San Diego is a -162 favorite despite being on the road.

Padres vs Pirates Spread

• The Pirates are at +1.5 on the runline against the Padres. The Pirates are -128 to cover the spread, and the Padres are +106.

Padres vs Pirates Over/Under

• The over/under for Padres-Pirates on May 2 is 7.5. The over is -122, and the under is -100.

Bet on San Diego Padres vs. Pittsburgh Pirates on FanDuel today!

Padres vs Pirates Betting Trends

• The Padres have come away with 11 wins in the 15 contests they have been listed as the favorites in this season.
• San Diego has been a -162 moneyline favorite on six occasions this season and won every time.
• The Padres and their opponents have hit the over in 12 of their 30 games with a total set by oddsmakers this season.
• In 30 games with a line this season, the Padres have a mark of 17-13-0 against the spread.
• The Pirates have won 35% of the games this season they were the underdog on the moneyline (7-13).
• In games it has played as a moneyline underdog with odds of +136 or longer, Pittsburgh has a record of 4-7 (36.4%).
• The Pirates have had an over/under set by bookmakers 32 times, and have combined with opponents to go over the total in 15 of those games (15-16-1).
• The Pirates have put together a 12-20-0 record against the spread this season (covering just 37.5% of the time).

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with 39 hits and an OBP of .409, plus a team-best slugging percentage of .602. He's batting .345.
• Among qualified hitters in MLB, his batting average ranks third, his on-base percentage ranks eighth, and he is seventh in slugging.
• Manny Machado is batting .279 with 10 doubles, two home runs and 10 walks, while slugging .423 with an on-base percentage of .336.
• He is 45th in batting average, 64th in on-base percentage and 71st in slugging among qualified batters.
• Machado takes a two-game streak with at least one hit into this contest. In his last five games he is hitting .263 with a double and three RBI.
• Luis Arraez has collected 28 base hits, an OBP of .333 and a slugging percentage of .447 this season.
• Arraez has picked up a hit in two straight games. In his last five games he is hitting .429 with a triple, a home run, two walks and four RBI.
• Xander Bogaerts has been key for San Diego with 25 hits, an OBP of .331 plus a slugging percentage of .350.

Pirates Player Leaders

• Oneil Cruz has 26 hits with a .363 on-base percentage, leading the Pirates in both statistics. He's batting .252 and slugging .534.
• He is 76th in batting average, 41st in on-base percentage and 17th in slugging percentage among all qualified hitters in the majors.
• Andrew McCutchen has six doubles, three home runs and 12 walks while hitting .264. He's slugging .437 with an on-base percentage of .354.
• Including all qualifying hitters, his batting average puts him 63rd, his on-base percentage is 50th, and he is 61st in slugging.
• Bryan Reynolds has put up a team-best .373 slugging percentage.
• Enmanuel Valdez is batting .232 with three doubles, two triples, two home runs and 11 walks.

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