Padres vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 12:11 a.m.

In MLB action on Wednesday, the San Diego Padres play the Washington Nationals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Padres vs Nationals Game Info

• San Diego Padres (42-36) vs. Washington Nationals (33-46)
• Date: Wednesday, June 25, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MASN2

Padres vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-146) | WSH: (+124)
• Spread: SD: -1.5 (+152) | WSH: +1.5 (-184)
• Total: 7.5 -- Over: (-118) | Under: (-104)

Padres vs Nationals Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 7-2, 3.64 ERA vs MacKenzie Gore (Nationals) - 3-7, 3.19 ERA

The Padres will give the ball to Nick Pivetta (7-2, 3.64 ERA), who is eyeing win No. 8 on the season, and the Nationals will turn to MacKenzie Gore (3-7, 3.19 ERA). Pivetta's team is 9-6-0 against the spread this season in his starts. Pivetta's team has a record of 3-4 this season when he starts and they are the favorite on the moneyline. The Nationals are 8-8-0 ATS in Gore's 16 starts with a set spread. The Nationals have been the moneyline underdog in eight of Gore's starts this season, and they went 4-4 in those games.

Padres vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.3%)

Padres vs Nationals Moneyline

• The moneyline numbers for Padres vs. Nationals reveal San Diego as the favorite (-146) and Washington as the underdog (+124) on the road.

Padres vs Nationals Spread

• The Nationals are +1.5 on the run line against the Padres. The Nationals are -184 to cover, and the Padres are +152.

Padres vs Nationals Over/Under

• An over/under of 7.5 has been set for Padres-Nationals on June 25, with the over being -118 and the under -104.

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Padres vs Nationals Betting Trends

• The Padres have been chosen as favorites in 38 games this year and have walked away with the win 23 times (60.5%) in those games.
• This season San Diego has come away with a win 16 times in 24 chances when named as a favorite of at least -146 on the moneyline.
• The Padres and their opponents have gone over the total this season in 33 of their 77 opportunities.
• In 77 games with a line this season, the Padres have a mark of 42-35-0 against the spread.
• The Nationals have been the moneyline underdog 58 total times this season. They've gone 29-29 in those games.
• Washington has gone 18-21 in games it has played as a moneyline underdog with odds of +124 or longer (46.2%).
• The Nationals have combined with opponents to hit the over on the total 38 times this season for a 38-36-1 record against the over/under.
• The Nationals have covered 52% of their games this season, going 39-36-0 against the spread.

Padres Player Leaders

• Manny Machado leads San Diego in OBP (.366), slugging percentage (.502) and total hits (90) this season. He has a .303 batting average.
• Among qualified hitters in MLB, his batting average ranks 15th, his on-base percentage ranks 27th, and he is 21st in slugging.
• Fernando Tatis Jr. is hitting .267 with 11 doubles, a triple, 15 home runs and 37 walks, while slugging .466 with an on-base percentage of .356.
• His batting average is 58th among qualified players, his on-base percentage 37th, and his slugging percentage 48th.
• Tatis brings a three-game streak with at least one hit into this contest. In his last five games he is hitting .167 with two home runs, four walks and six RBIs.
• Luis Arraez has 82 hits this season and has a slash line of .279/.309/.391.
• Arraez heads into this game with 10 games in a row with at least one hit. During his last 10 outings he is hitting .311 with a double, a triple and four RBIs.
• Gavin Sheets has 12 home runs, 46 RBI and a batting average of .266 this season.

Nationals Player Leaders

• James Wood has 85 hits with a .379 on-base percentage and a .569 slugging percentage, all club-highs for the Nationals. He's batting .284.
• Including all the qualifying hitters in MLB, his batting average ranks 34th, his on-base percentage ranks 17th, and he is fifth in slugging.
• Wood brings a three-game hitting streak into this game. In his last five games he is batting .318 with four home runs, two walks and nine RBIs.
• C.J. Abrams is hitting .284 with 16 doubles, two triples, 11 home runs and 20 walks. He's slugging .487 with an on-base percentage of .356.
• Including all qualifying hitters, he ranks 34th in batting average, 37th in on-base percentage and 33rd in slugging percentage.
• Luis Garcia is batting .274 with 19 doubles, seven home runs and 15 walks.
• Nathaniel Lowe is hitting .232 with 12 doubles, 13 home runs and 28 walks.

Padres vs Nationals Head to Head

• 6/23/2025: 10-6 WSH (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/25/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/24/2024: 12-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/23/2024: 4-0 SD (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/26/2024: 8-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 6/25/2024: 9-7 SD (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/24/2024: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/25/2023: 8-3 WSH (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 6/24/2023: 2-0 WSH (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 6/23/2023: 13-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -300, Underdog Moneyline: +245)

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