Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 20

Odds updated as of 8:11 a.m.

The San Diego Padres versus the San Francisco Giants is on the MLB schedule for Wednesday.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Giants Game Info

• San Diego Padres (70-56) vs. San Francisco Giants (61-65)
• Date: Wednesday, August 20, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: MLB Network, SDPA, and NBCS-BA

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-158) | SF: (+134)
• Spread: SD: -1.5 (+126) | SF: +1.5 (-152)
• Total: 8 -- Over: (-115) | Under: (-105)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: JP Sears (Padres) - 0-0, 0.00 ERA vs Landen Roupp (Giants) - 7-6, 3.54 ERA

The probable starters are JP Sears for the Padres and Landen Roupp (7-6) for the Giants. Sears did not appear in a game when his team was the moneyline favorite last season. The Giants have an 11-10-0 ATS record in Roupp's 21 starts with a set spread. The Giants are 7-6 in Roupp's 13 starts this season that they were the underdog on the moneyline.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (53.4%)

Padres vs Giants Moneyline

• Looking at the moneyline for Giants-Padres, San Francisco is the underdog at +134, and San Diego is -158 playing at home.

Padres vs Giants Spread

• The Giants are +1.5 on the run line against the Padres. The Giants are -152 to cover, and the Padres are +126.

Padres vs Giants Over/Under

• The Padres-Giants contest on Aug. 20 has been given an over/under of 8 runs. The over is set at -115 and the under at -105.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have been chosen as favorites in 65 games this year and have walked away with the win 40 times (61.5%) in those games.
• This season San Diego has come away with a win 17 times in 28 chances when named as a favorite of at least -158 on the moneyline.
• Contests with the Padres have gone over the total set by bookmakers in 52 of 124 chances this season.
• The Padres have posted a record of 69-55-0 against the spread this season.
• The Giants have won 22 of the 47 games they were the moneyline underdog this season (46.8%).
• When playing as a moneyline underdog with odds of +134 or longer, San Francisco has a 4-7 record (winning only 36.4% of its games).
• The Giants have had an over/under set by bookmakers 126 times, and have combined with opponents to go over the total in 56 of those games (56-64-6).
• The Giants have a 54-72-0 record against the spread this season (covering 42.9% of the time).

Padres Player Leaders

• Manny Machado has 142 hits to go with a slugging percentage of .479, both of which lead San Diego hitters this season. He has a .292 batting average and an on-base percentage of .354.
• He ranks 15th in batting average, 36th in on-base percentage, and 33rd in slugging among all qualified hitters in baseball.
• Machado will look for his third straight game with a hit in this contest. During his last five outings he is hitting .200 with a double, a walk and an RBI.
• Fernando Tatis Jr. leads San Diego in OBP (.370) this season, fueled by 124 hits. He's batting .264 while slugging .431.
• His batting average is 60th among qualified players, his on-base percentage 15th, and his slugging percentage 79th.
• Luis Arraez has hit six homers with a team-high .398 SLG this season.
• Arraez brings a four-game hitting streak into this game. During his last five outings he is hitting .300 with four doubles, a walk and two RBIs.
• Xander Bogaerts is batting .262 with a .331 OBP and 43 RBI for San Diego this season.

Giants Player Leaders

• Rafael Devers has totaled 121 hits with a .376 on-base percentage, leading the Giants in both categories. He's batting .255 and slugging .466.
• Including all the qualifying hitters in the majors, his batting average places him 89th, his on-base percentage is 10th, and he is 48th in slugging.
• Jung Hoo Lee has 29 doubles, 10 triples, seven home runs and 39 walks while hitting .262. He's slugging .417 with an on-base percentage of .325.
• He is currently 66th in batting average, 87th in on-base percentage and 89th in slugging percentage among all qualified hitters.
• Willy Adames has 18 doubles, two triples, 19 home runs and 57 walks while hitting .222.
• Heliot Ramos is slugging .406 to pace his team.

Padres vs Giants Head to Head

• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/5/2025: 3-2 SF (Favorite: Giants, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/4/2025: 6-5 SF (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/3/2025: 3-2 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 6/2/2025: 1-0 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/30/2025: 5-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)

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