Padres vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 7

Odds updated as of 8:11 a.m.

The MLB slate on Friday includes the San Diego Padres facing the Houston Astros.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Padres vs Astros Game Info

• San Diego Padres (60-56) vs. Houston Astros (59-57)
• Date: Friday, August 7, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and SCHN

Padres vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-120) | HOU: (+102)
• Spread: SD: +1.5 (-205) | HOU: -1.5 (+168)
• Total: 8.5 -- Over: (+102) | Under: (-124)

Padres vs Astros Probable Starting Pitchers

Probable Pitchers: Robbie Ray (Padres) - 10-6, 3.08 ERA vs Ronel Blanco (Astros) - 0-1, 7.36 ERA

The probable starters are Robbie Ray (10-6) for the Padres and Ronel Blanco (0-1) for the Astros. When Ray starts, his team is 11-8-0 against the spread this season. Ray's team has a record of 6-2 this season when he starts and they are the favorite on the moneyline. When Blanco starts, the Astros have gone 2-1-0 against the spread. The Astros were the underdog on the moneyline for two Blanco starts this season -- they split the games.

Padres vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (55.6%)

Padres vs Astros Moneyline

• The moneyline numbers for Padres vs. Astros reveal San Diego as the favorite (-120) and Houston as the underdog (+102) on the road.

Padres vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Padres. The Astros are +168 to cover, while the Padres are -205 to cover as a 1.5-run underdog on the runline.

Padres vs Astros Over/Under

• A total of 8.5 runs has been set for the Padres-Astros game on Aug. 7, with the over available at +102 and the under at -124.

Bet on San Diego Padres vs. Houston Astros on FanDuel today!

Padres vs Astros Betting Trends

• The Padres have come away with 26 wins in the 48 contests they have been listed as the favorites in this season.
• San Diego has a record of 22-17 in contests when oddsmakers favor them by -120 or more on the moneyline.
• The Padres and their opponents have gone over the total this season in 53 of their 116 opportunities.
• The Padres have an against the spread record of 64-52-0 in 116 games with a line this season.
• The Astros have won 34 of the 65 games they were the underdog on the moneyline this season (52.3%).
• In games it has played as a moneyline underdog with odds of +102 or longer, Houston has gone 26-22 (54.2%).
• In the 116 games bookmakers have set an over/under for the Astros, they have combined with opponents to go over the total 63 times (63-49-4).
• The Astros have covered 50% of their games this season, going 58-58-0 ATS.

Padres Player Leaders

• Fernando Tatis Jr. leads San Diego with an OBP of .350, plus a team-best slugging percentage of .403. He's batting .280 on the season.
• Among all qualified batters, he is 32nd in batting average, his on-base percentage ranks 48th, and he is 97th in slugging.
• Tatis hopes to build on a three-game hitting streak in this matchup. During his last five outings he is batting .150 with two doubles, a home run, two walks and an RBI.
• Manny Machado has 88 hits, which ranks first among San Diego batters this season. He's batting .210 with 43 extra-base hits. He's also slugging .422 with an on-base percentage of .294.
• Among qualifying batters, he ranks 142nd in batting average, 131st in on-base percentage and 75th in slugging percentage.
• Jackson Merrill has 106 hits this season and has a slash line of .241/.292/.396.
• Xander Bogaerts has nine home runs, 41 RBI and a batting average of .227 this season.

Astros Player Leaders

• Yordan Alvarez has put up an on-base percentage of .442, a slugging percentage of .640, and has 136 hits, all club-bests for the Astros (while batting .329).
• Including all the qualifying hitters in MLB, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Alvarez brings a six-game hitting streak into this game. During his last 10 games he is batting .371 with four doubles, a home run, 13 walks and eight RBIs.
• Isaac Paredes has 18 doubles, a triple, 15 home runs and 45 walks while batting .249. He's slugging .412 with an on-base percentage of .346.
• Including all qualified players, his batting average places him 85th, his on-base percentage is 53rd, and he is 87th in slugging.
• Christian Walker has 24 doubles, a triple, 22 home runs and 38 walks while batting .240.
• Jeremy Pena has 12 doubles, a triple, 13 home runs and 20 walks while hitting .311.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!