Padres vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for May 12

Odds updated as of 9:11 a.m.

The San Diego Padres will take on the Los Angeles Angels in MLB action on Monday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Angels Game Info

• San Diego Padres (25-14) vs. Los Angeles Angels (16-23)
• Date: Monday, May 12, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSW

Padres vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-225) | LAA: (+188)
• Spread: SD: -1.5 (+104) | LAA: +1.5 (-125)
• Total: 7 -- Over: (-122) | Under: (-100)

Padres vs Angels Probable Starting Pitchers

Probable Pitchers: Michael King (Padres) - 4-1, 2.22 ERA vs Yusei Kikuchi (Angels) - 0-4, 3.83 ERA

This contest's pitching matchup is set, as the Padres will send Michael King (4-1) to the mound, while Yusei Kikuchi (0-4) will answer the bell for the Angels. When King starts, his team is 4-4-0 against the spread this season. King's team has won 66.7% of his starts when they are favored on the moneyline (4-2). The Angels have a 3-5-0 ATS record in Kikuchi's eight starts with a set spread. The Angels have been the moneyline underdog in six of Kikuchi's starts this season, and they went 1-5 in those games.

Padres vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (68.5%)

Padres vs Angels Moneyline

• The moneyline numbers for Padres vs. Angels reveal San Diego as the favorite (-225) and Los Angeles as the underdog (+188) on the road.

Padres vs Angels Spread

• The Padres are 1.5-run home favorites on the runline against the Angels. The Padres are +104 to cover, and the Angels are -125.

Padres vs Angels Over/Under

• The over/under for the Padres versus Angels contest on May 12 has been set at 7, with -122 odds on the over and -100 odds on the under.

Bet on San Diego Padres vs. Los Angeles Angels on FanDuel today!

Padres vs Angels Betting Trends

• The Padres have been favorites in 19 games this season and have come away with the win 14 times (73.7%) in those contests.
• San Diego has a record of 2-1 in contests when oddsmakers favor them by -225 or more on the moneyline.
• The Padres and their opponents have gone over in 17 of their 38 games with a total set by sportsbooks this season.
• In 38 games with a line this season, the Padres have a mark of 23-15-0 against the spread.
• The Angels have won 12 of the 31 games they were the moneyline underdog this season (38.7%).
• Los Angeles has not yet played a game with moneyline odds of +188 or longer.
• The Angels have had an over/under set by oddsmakers 39 times, and have combined with opponents to go over the total in 21 of those games (21-17-1).
• The Angels have put together a 15-24-0 record ATS this season (covering only 38.5% of the time).

Padres Player Leaders

• Fernando Tatis Jr. has 47 hits and an OBP of .388 to go with a slugging percentage of .551. All three of those stats are best among San Diego hitters this season. He has a .320 batting average, as well.
• Among all qualified hitters in the majors, he ranks eighth in batting average, 15th in on-base percentage, and 10th in slugging.
• Tatis will look for his sixth straight game with a hit in this contest. In his last five games he is batting .333 with a double, a home run, two walks and five RBIs.
• Manny Machado has hit three homers this season while driving in 20 runs. He's batting .324 this season and slugging .483 with an on-base percentage of .385.
• His batting average ranks seventh among qualified players, his on-base percentage 17th, and his slugging percentage 33rd.
• Machado enters this game looking to extend his 11-game hit streak. During his last 10 outings he is batting .447 with four doubles, a home run, five walks and eight RBIs.
• Luis Arraez is batting .289 with a .415 slugging percentage and 15 RBI this year.
• Xander Bogaerts has two home runs, 16 RBI and a batting average of .244 this season.

Angels Player Leaders

• Nolan Schanuel has racked up a team-high OBP (.342) and slugging percentage (.367). He's batting .258.
• Including all qualified hitters in the majors, he is 76th in batting average, 68th in on-base percentage and 125th in slugging percentage.
• Joseph Ward is batting .182 with six doubles, eight home runs and nine walks. He's slugging .385 with an on-base percentage of .226.
• His batting average ranks 156th among all qualified players, his on-base percentage ranks 163rd, and he is 104th in slugging.
• Jorge Soler has eight doubles, six home runs and 11 walks while batting .226.
• Logan O'Hoppe has racked up 32 hits to pace his team.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!