Orioles vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 7

Odds updated as of 1:12 p.m.

The Baltimore Orioles will face the Cleveland Guardians in MLB action on Monday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Orioles vs Guardians Game Info

• Baltimore Orioles (69-75) vs. Cleveland Guardians (73-71)
• Date: Monday, September 7, 2026
• Time: 1:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and CleGuardians.TV

Orioles vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-136) | CLE: (+116)
• Spread: BAL: -1.5 (+160) | CLE: +1.5 (-194)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Orioles vs Guardians Probable Starting Pitchers

Probable Pitchers: Trevor Rogers (Orioles) - 9-9, 4.30 ERA vs Joey Cantillo (Guardians) - 9-8, 3.81 ERA

The probable starters are Trevor Rogers (9-9) for the Orioles and Joey Cantillo (9-8) for the Guardians. Rogers' team is 12-14-0 against the spread in his starts this season. When Rogers starts a game and his team is the favorite on the moneyline, they have a record of 8-9. The Guardians have a 17-12-0 record against the spread in Cantillo's starts. The Guardians are 9-5 in Cantillo's 14 starts this season that they were the underdog on the moneyline.

Orioles vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (51.6%)

Orioles vs Guardians Moneyline

• The Orioles vs Guardians moneyline has Baltimore as a -136 favorite, while Cleveland is a +116 underdog on the road.

Orioles vs Guardians Spread

• The Guardians are at the Orioles, and are +1.5 on the runline. The Guardians are +160 to cover the spread, and the Orioles are -194.

Orioles vs Guardians Over/Under

• The over/under for the Orioles versus Guardians game on Sept. 7 has been set at 7.5, with +102 odds on the over and -124 odds on the under.

Bet on Baltimore Orioles vs. Cleveland Guardians on FanDuel today!

Orioles vs Guardians Betting Trends

• The Orioles have won in 35, or 53%, of the 66 contests they have been named as odds-on favorites in this year.
• This season Baltimore has come away with a win 15 times in 29 chances when named as a favorite of at least -136 on the moneyline.
• The Orioles and their opponents have gone over in 71 of their 143 games with a total set by sportsbooks this season.
• The Orioles have an against the spread mark of 73-70-0 in 143 games with a line this season.
• The Guardians have put together a 26-26 record in games they were the underdog on the moneyline (winning 50% of those games).
• Cleveland is 14-11 (winning 56% of its games) when playing as a moneyline underdog of +116 or longer.
• The Guardians have combined with opponents to hit the over on the total 65 times this season for a 65-71-0 record against the over/under.
• The Guardians have a 64-72-0 record ATS this season (covering 47.1% of the time).

Orioles Player Leaders

• Pete Alonso has 144 hits and an OBP of .358 to go with a slugging percentage of .495. All three of those stats are best among Baltimore hitters this season. He has a .267 batting average, as well.
• Among qualified hitters in the majors, his batting average ranks 50th, his on-base percentage ranks 32nd, and he is 15th in slugging.
• Gunnar Henderson is batting .220 with 25 doubles, five triples, 22 home runs and 60 walks, while slugging .399 with an on-base percentage of .304.
• He is 126th in batting average, 116th in on-base percentage and 92nd in slugging among qualifying hitters.
• Leody Taveras is batting .216 with a .346 slugging percentage and 52 RBI this year.
• Coby Mayo has been key for Baltimore with 77 hits, an OBP of .287 plus a slugging percentage of .444.

Guardians Player Leaders

• Chase DeLauter has racked up a team-high slugging percentage (.458) while leading the Guardians in hits (131). He's batting .294 and with an on-base percentage of .365.
• Including all the qualified hitters in MLB, he is 10th in batting average, 21st in on-base percentage and 43rd in slugging percentage.
• Jose Ramirez is batting .237 with 24 doubles, 11 home runs and 56 walks. He's slugging .378 with an on-base percentage of .330.
• He is currently 106th in batting average, 71st in on-base percentage and 113th in slugging percentage among all qualified batters.
• Steven Kwan has accumulated an on-base percentage of .372, a team-high for the Guardians.
• Brayan Rocchio is batting .246 with 20 doubles, two triples, 13 home runs and 33 walks.

Orioles vs Guardians Head to Head

• 4/19/2026: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 4/18/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/17/2026: 6-4 BAL (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2026: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 4-3 BAL (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/23/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/22/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/21/2025: 10-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/17/2025: 6-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2025: 9-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)

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