Orioles vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 27

Odds updated as of 10:12 p.m.

MLB action on Thursday includes the Baltimore Orioles taking on the St. Louis Cardinals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Cardinals Game Info

• Baltimore Orioles (64-68) vs. St. Louis Cardinals (66-67)
• Date: Thursday, August 27, 2026
• Time: 2:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and MASN

Orioles vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-118) | STL: (+100)
• Spread: BAL: -1.5 (+140) | STL: +1.5 (-170)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Orioles vs Cardinals Probable Starting Pitchers

Probable Pitchers: Trevor Rogers (Orioles) - 9-8, 4.14 ERA vs TBA (Cardinals)

Trevor Rogers (9-8) take the hill for the Orioles in this matchup. The Cardinals, however, have yet to list a starter. Rogers' team is 12-12-0 against the spread this season in his starts. Rogers' team has a record of 8-7 this season when he starts and they are the favorite on the moneyline.

Orioles vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (53.1%)

Orioles vs Cardinals Moneyline

• St. Louis is a +100 underdog on the moneyline, while Baltimore is a -118 favorite on the road.

Orioles vs Cardinals Spread

• The Cardinals are +1.5 on the run line against the Orioles. The Cardinals are -170 to cover, and the Orioles are +140.

Orioles vs Cardinals Over/Under

• An over/under of 8.5 has been set for Orioles-Cardinals on Aug. 27, with the over being +100 and the under -122.

Bet on Baltimore Orioles vs. St. Louis Cardinals on FanDuel today!

Orioles vs Cardinals Betting Trends

• The Orioles have been chosen as favorites in 58 games this year and have walked away with the win 30 times (51.7%) in those games.
• This season Baltimore has come away with a win 25 times in 49 chances when named as a favorite of at least -118 on the moneyline.
• The Orioles' games have gone over the total in 67 of their 131 opportunities.
• In 131 games with a line this season, the Orioles have a mark of 69-62-0 against the spread.
• The Cardinals have won 40 of the 87 games they were the underdog on the moneyline this season (46%).
• St. Louis has gone 34-35 when it has played as a moneyline underdog with odds of +100 or longer (49.3%).
• In the 129 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 55 times (55-67-7).
• The Cardinals have collected a 68-61-0 record ATS this season (covering 52.7% of the time).

Orioles Player Leaders

• Pete Alonso has 137 hits and an OBP of .364 to go with a slugging percentage of .512. All three of those stats are tops among Baltimore hitters this season. He has a .276 batting average, as well.
• Among all qualified hitters in the majors, his batting average ranks 29th, his on-base percentage ranks 25th, and he is 13th in slugging.
• Gunnar Henderson has 23 doubles, four triples, 20 home runs and 55 walks. He's batting .219 and slugging .392 with an on-base percentage of .302.
• Among all qualified hitters, he ranks 124th in batting average, 112th in on-base percentage and 102nd in slugging percentage.
• Leody Taveras is batting .228 with a .357 slugging percentage and 46 RBI this year.
• Samuel Basallo has 17 home runs, 48 RBI and a batting average of .233 this season.

Cardinals Player Leaders

• Alec Burleson has accumulated a team-best .487 slugging percentage. He's batting .291 with an on-base percentage of .356.
• He is 11th in batting average, 36th in on-base percentage and 23rd in slugging percentage among all qualified hitters in the majors.
• Burleson brings an 11-game hitting streak into this matchup. In his last 10 games he is batting .368 with three doubles, a home run, a walk and 10 RBIs.
• Jordan Walker has 143 hits to pace his team. He has a batting average of .285 while slugging .502 with an on-base percentage of .343.
• Including all qualifying players, he ranks 20th in batting average, 52nd in on-base percentage and 17th in slugging percentage.
• JJ Wetherholt is hitting .245 with 14 doubles, 17 home runs and 62 walks.
• Ivan Herrera has a .358 on-base percentage to lead his team.

Orioles vs Cardinals Head to Head

• 8/25/2026: 13-1 BAL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -105)
• 5/28/2025: 6-4 STL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/27/2025: 7-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/26/2025: 5-2 BAL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/20/2024: 6-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/13/2023: 1-0 STL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/12/2023: 5-2 STL (Favorite: Orioles, Spread: -1.5, Total: 11, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/11/2023: 11-5 BAL (Favorite: Orioles, Spread: -1.5, Total: 10, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/11/2022: 10-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 5/10/2022: 5-3 BAL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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