Oregon vs James Madison Prediction, Odds, Picks, Best Bets for 2025 CFP First Round

Saturday's slate in college football includes a matchup between the Oregon Ducks and the James Madison Dukes.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information about today's NCAA football betting odds.

Oregon vs James Madison Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Oregon: (-2222) | James Madison: (+1100)
• Spread: Oregon: -21.5 (100) | James Madison: +21.5 (-122)
• Total: 47.5 -- Over: (-110) | Under: (-110)

Oregon vs James Madison Betting Trends

• Oregon's record against the spread is 7-5-0.
• Against the spread as 21.5-point or better favorites, Oregon is 3-3.
• This season, six of Oregon's 12 games have hit the over.
• James Madison is 8-5-0 against the spread this season.
• James Madison has played 13 games this year, and six of them have gone over the total.

Oregon vs James Madison Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Ducks win (88.1%)

Oregon vs James Madison Point Spread

James Madison is an underdog by 21.5 points against Oregon. James Madison is -122 to cover the spread, and Oregon is +100.

Oregon vs James Madison Over/Under

Oregon versus James Madison on Dec. 20 has an over/under of 47.5 points, with the over -110 and the under -110.

Oregon vs James Madison Moneyline

The moneyline numbers for Oregon vs. James Madison reveal Oregon as the favorite (-2222) and James Madison as the underdog (+1100).

Oregon vs. James Madison Points Insights

Oregon vs. James Madison Game Info

• Game day: Saturday, December 20, 2025
• Game time: 7:30 p.m. ET
• TV channel: TNT
• Location: Eugene, Oregon
• Stadium: Autzen Stadium

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