NFL Week 2 Schedule 2026: Odds for Every Game

NFL Week 2 Schedule Highlights

• Lions at Bills
• Bengals at Texans
• Colts at Chiefs

Week 1 of the 2026 NFL season is nearly in the books, which means it's time to turn our attention to Week 2.

The second week of the season features another 16-game slate, beginning with a compelling Thursday Night Football matchup between the Detroit Lions and Buffalo Bills. Sunday brings a loaded 14-game schedule before the New York Giants and Los Angeles Rams wrap up the week on Monday Night Football.

Here's the complete NFL Week 2 schedule, including the date and kickoff time for every game.

All NFL odds via FanDuel Sportsbook, and they may change after this article is published.

Week 2 NFL Odds and Schedule

Thursday, September 17

Detroit Lions at Buffalo Bills

Sunday, September 20

Philadelphia Eagles at Tennessee Titans

Pittsburgh Steelers at New England Patriots

Minnesota Vikings at Chicago Bears

Carolina Panthers at Atlanta Falcons

Green Bay Packers at New York Jets

New Orleans Saints at Baltimore Ravens

Cincinnati Bengals at Houston Texans

Cleveland Browns at Tampa Bay Buccaneers

Jacksonville Jaguars at Denver Broncos

Las Vegas Raiders at Los Angeles Chargers

Seattle Seahawks at Arizona Cardinals

Miami Dolphins at San Francisco 49ers

Washington Commanders at Dallas Cowboys

Indianapolis Colts at Kansas City Chiefs

Monday, September 21

New York Giants at Los Angeles Rams

NFL Betting FAQ

What is the point spread in NFL betting?

The sportsbook assigns a favorite (indicated by a minus sign, like -6.5) and an underdog (indicated by a plus sign, like +6.5). If you bet the favorite, in this example, they need to win by more than 6.5 points for your bet to win. If you bet the underdog, they need to either win outright or lose by fewer than 6.5 points. The half-point eliminates the possibility of a push (tie).

What does moneyline betting mean in the NFL?

A moneyline bet is a straight-up wager on which team wins the game — no spread involved. Favorites carry a negative number (e.g., -180), meaning you'd need to wager $180 to win $100. Underdogs carry a positive number (e.g., +155), meaning a $100 bet would return $155 in profit. Moneylines allow you to back a team without having to worry about margin of victory.

What is the over/under (total) in NFL betting?

The over/under — also called the total — is a bet on the combined score of both teams. FanDuel Sportsbook sets a number (for example, 47.5 points), and you wager on whether the final total will add up to more than 47.5 points or fewer than 47.5 points. It doesn't matter which team wins; all that counts is how many points are scored in regulation and overtime combined.

What are NFL player props?

Player props are individual performance bets focused on a specific player's stats rather than the game outcome. You can bet on a player to go over or under. Common NFL props include passing yards, rushing yards, receiving yards, touchdowns, receptions, and completions. FanDuel Sportsbook offers a wide variety of player props for every game, often including alternate lines at adjusted odds.

What is a same-game parlay (SGP)?

A same-game parlay lets you bundle multiple bets from the same NFL game — such as a team to cover the spread, a quarterback to throw for over 275 yards, and a wide receiver to score a touchdown — all into one ticket. Because the outcomes are correlated, the odds are adjusted accordingly. FanDuel Sportsbook offers same-game parlays for every game on the slate.

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Which NFL bets stand out to you? Check out FanDuel Sportsbook's latest NFL odds to see the full menu of options.

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The above author is a FanDuel employee and is not eligible to compete in public daily fantasy contests or place sports betting wagers on FanDuel. The advice provided by the author does not necessarily represent the views of FanDuel. Taking the author's advice will not guarantee a successful outcome. You should use your own judgment when participating in daily fantasy contests or placing sports wagers.