NFL Predictions Sunday 4PM Games: 3 Best Spread Bets and 3 Best Over/Under Bets

NFL Sunday 4PM Best Bets in Summary

• San Francisco 49ers -7.5
• New Orleans Saints -3.5
• Minnesota Vikings -1.5
• Over 48.5 (Cardinals vs 49ers)
• Under 42.5 (Vikings vs Buccaneers)
• Over 52.5 (Ravens vs Cowboys)

The NFL's 4 p.m. ET window closes out the afternoon slate, and a look at how the market has priced each line turns up some real, well-supported signals — spots where the vig itself points to where the confidence is concentrated. Here are the three best spread bets and three best over/under bets for this window.

All NFL odds come from FanDuel Sportsbook's NFL betting odds and may change after this article is published.

Best Spread Bets for NFL Sunday 4PM Games

Arizona Cardinals at San Francisco 49ers (Sun, 4:06 p.m. ET)

San Francisco 49ers -7.5 (-106)

The single cheapest favorite price on this window — San Francisco costs almost nothing to back at -106 while Arizona getting the points costs -114, an 8-cent gap. A real, clean number without needing a blowout to justify it, especially paired with the highest total of the four games.

Las Vegas Raiders at New Orleans Saints (Sun, 4:25 p.m. ET)

New Orleans Saints -3.5 (-104)

A genuine value spot. New Orleans as the favorite is priced at a real discount (-104) while Las Vegas getting the points costs -118 — a 14-cent gap in the favorite's favor, a real sign the market is comfortable concentrating confidence on New Orleans at home.

Minnesota Vikings at Tampa Bay Buccaneers (Sun, 4:06 p.m. ET)

Minnesota Vikings -1.5 (-104)

Same shape as the Saints line — Minnesota as the modest favorite costs less (-104) than Tampa Bay getting the points (-118). A near pick'em number made slightly more attractive by that pricing gap.

Best Over/Under Bets for NFL Sunday 4PM Games

Arizona Cardinals at San Francisco 49ers (Sun, 4:06 p.m. ET)

Over 48.5 (-105)

The highest total of the entire 4 p.m. window, and the over still comes at a real discount to the under (-115). A genuine sign the market expects this one to be a track meet rather than a defensive grind, even with San Francisco a heavy favorite.

Minnesota Vikings at Tampa Bay Buccaneers (Sun, 4:06 p.m. ET)

Under 42.5 (-105)

The lowest total of the four games, and the under is priced essentially even against the over (-105 vs -115) — a real, well-supported number for a genuinely close, competitive matchup that doesn't need to turn into a shootout.

Baltimore Ravens at Dallas Cowboys (Sun, 4:25 p.m. ET)

Over 52.5 (-114)

The single highest total on the board today across every window. Both offenses carry real, established firepower, and a number this size is a genuine signal the market expects both units to get there.