NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 5

The Week 5 NFL lineup features top teams in action. Among those contests is the Denver Broncos taking on the Philadelphia Eagles.

Take a peek at our betting breakdown for the NFL's Week 5.

Rams vs. 49ers

The Los Angeles Rams (3-1), who took down the Colts in their last contest, host the San Francisco 49ers (3-1) at SoFi Stadium on Oct. 2 at 8:15 p.m. ET. The 49ers were defeated by the Jaguars in their last game.

• Game Preview: San Francisco 49ers at Los Angeles Rams
• Projected Favorite: Rams (61.46% win probability)
• Spread: Los Angeles (-5.5)
• Total: 46.5 -- Over: (-122) | Under: (+100)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Los Angeles vs. San Francisco with FanDuel Sportsbook.

Browns vs. Vikings

Justin Jefferson and the Minnesota Vikings (2-2) will get a tough test when they match up with the Cleveland Browns (1-3), who have the NFL's fourth-best pass D, on Sunday, Oct. 5 at 9:30 a.m. ET. Jefferson is fifth-best in the league in receiving yards.

• Game Preview: Minnesota Vikings vs. Cleveland Browns
• Projected Favorite: Vikings (73.34% win probability)
• Spread: Minnesota (-3.5)
• Total: 35.5 -- Over: (-115) | Under: (-105)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Cleveland vs. Minnesota with FanDuel Sportsbook.

Ravens vs. Texans

One of the top quarterbacks in football will be on display when Lamar Jackson and the Baltimore Ravens (1-3) host the Houston Texans (1-3) on Sunday, October 5, 2025.

• Game Preview: Houston Texans at Baltimore Ravens
• Projected Favorite: Ravens (65.51% win probability)
• Spread: Houston (-1.5)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Houston with FanDuel Sportsbook.

Jets vs. Cowboys

At MetLife Stadium on Sunday, George Pickens and the Dallas Cowboys (1-2-1) meet Garrett Wilson and the New York Jets (0-4) in a matchup featuring a pair of outstanding pass-catchers, starting at 1 p.m. ET.

• Game Preview: Dallas Cowboys at New York Jets
• Projected Favorite: Cowboys (51.65% win probability)
• Spread: Dallas (-2.5)
• Total: 47.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Dallas with FanDuel Sportsbook.

Panthers vs. Dolphins

When the Miami Dolphins (1-3) and the Carolina Panthers (1-3) match up on Sunday, Oct. 5 at 1 p.m. ET, the Dolphins will be looking to follow up their recent victory over the Jets with another win, and the Panthers will be attempting to rebound from a loss to the Patriots.

• Game Preview: Miami Dolphins at Carolina Panthers
• Projected Favorite: Dolphins (55.41% win probability)
• Spread: Miami (-1.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Miami with FanDuel Sportsbook.

Eagles vs. Broncos

The Philadelphia Eagles (4-0), who took down against the Buccaneers in their previous game, host the Denver Broncos (2-2) at Lincoln Financial Field on Oct. 5 at 1 p.m. ET. The Broncos picked up the win against the Bengals in their last game.

• Game Preview: Denver Broncos at Philadelphia Eagles
• Projected Favorite: Eagles (68.77% win probability)
• Spread: Philadelphia (-4.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Philadelphia vs. Denver with FanDuel Sportsbook.

Colts vs. Raiders

Star running back Jonathan Taylor and the Indianapolis Colts (3-1) play the Las Vegas Raiders (1-3) on Sunday at 1 p.m. ET at Lucas Oil Stadium.

• Game Preview: Las Vegas Raiders at Indianapolis Colts
• Projected Favorite: Colts (73.31% win probability)
• Spread: Indianapolis (-6.5)
• Total: 47.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Indianapolis vs. Las Vegas with FanDuel Sportsbook.

Saints vs. Giants

When the New Orleans Saints (0-4) and the New York Giants (1-3) play on Sunday, Oct. 5 at 1 p.m. ET, the Saints will be trying to bounce back from a loss to the Bills, and the Giants will be aiming to follow up their recent victory over the Chargers with another win.

• Game Preview: New York Giants at New Orleans Saints
• Projected Favorite: Saints (65.97% win probability)
• Spread: New Orleans (-1.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New Orleans vs. New York with FanDuel Sportsbook.

Seahawks vs. Buccaneers

The Seattle Seahawks (3-1), who defeated the Cardinals in their previous contest, host the Tampa Bay Buccaneers (3-1) at Lumen Field on Oct. 5 at 4:05 p.m. ET. The Buccaneers were taken down by the Eagles in their last game.

• Game Preview: Tampa Bay Buccaneers at Seattle Seahawks
• Projected Favorite: Seahawks (51.05% win probability)
• Spread: Seattle (-3)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Seattle vs. Tampa Bay with FanDuel Sportsbook.

Cardinals vs. Titans

Trey McBride will lead the Arizona Cardinals (2-2) into their battle versus the Tennessee Titans (0-4) at State Farm Stadium on Sunday at 4:05 p.m. ET.

• Game Preview: Tennessee Titans at Arizona Cardinals
• Projected Favorite: Cardinals (86.59% win probability)
• Spread: Arizona (-8.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Arizona vs. Tennessee with FanDuel Sportsbook.

Chargers vs. Commanders

The Los Angeles Chargers (3-1) are scheduled to collide with the Washington Commanders (2-2) at SoFi Stadium on Sunday, Oct. 5 at 4:25 p.m. ET. Both squads lost their previous game, as the Chargers were defeated by the Giants 21-18, and the Commanders lost 34-27 to the Falcons.

• Game Preview: Washington Commanders at Los Angeles Chargers
• Projected Favorite: Chargers (58.27% win probability)
• Spread: Los Angeles (-2.5)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Washington with FanDuel Sportsbook.

Bengals vs. Lions

One of the top pass-catchers in football will be on show when Amon-Ra St. Brown and the Detroit Lions (3-1) visit the Cincinnati Bengals (2-2) on Sunday, October 5, 2025.

• Game Preview: Detroit Lions at Cincinnati Bengals
• Projected Favorite: Lions (76.94% win probability)
• Spread: Detroit (-10.5)
• Total: 48.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Cincinnati vs. Detroit with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!