NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 4

The outings in a Week 4 NFL lineup that shouldn't be missed include the Denver Broncos playing the San Francisco 49ers at Levi's Stadium.

If you're seeking additional betting information for Week 4 in the NFL, we have you covered with betting odds for each of the big matchups.

Browns vs. Steelers

The Cleveland Browns (2-1) will host the Pittsburgh Steelers (2-1) on Thursday at 8:15 p.m. ET.

• Game Preview: Pittsburgh Steelers at Cleveland Browns
• Projected Favorite: Steelers (53.43% win probability)
• Spread: Pittsburgh (-2.5)
• Total: 38.5 -- Over: (-104) | Under: (-118)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Cleveland vs. Pittsburgh with FanDuel Sportsbook.

Commanders vs. Colts

Jonathan Taylor will lead the Indianapolis Colts (1-2) into their battle versus the Washington Commanders (1-2) at Tottenham Hotspur Stadium on Sunday at 9:30 a.m. ET.

• Game Preview: Indianapolis Colts vs. Washington Commanders
• Projected Favorite: Colts (58.05% win probability)
• Spread: Indianapolis (-3.5)
• Total: 47.5 -- Over: (-102) | Under: (-120)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Washington vs. Indianapolis with FanDuel Sportsbook.

Ravens vs. Titans

Star running back Derrick Henry and the Baltimore Ravens (2-1) play the Tennessee Titans (0-3) on Sunday at 1 p.m. ET at M&T Bank Stadium.

• Game Preview: Tennessee Titans at Baltimore Ravens
• Projected Favorite: Ravens (83.38% win probability)
• Spread: Baltimore (-11.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Tennessee with FanDuel Sportsbook.

Bengals vs. Jaguars

On Sunday, Oct. 4 at 1 p.m. ET, the Cincinnati Bengals (2-1) will aim to rebound from their recent 30-27 loss to the Steelers when they match up with the Jacksonville Jaguars (2-1) at Paycor Stadium. The Jaguars won their last game 35-6 versus the Patriots.

• Game Preview: Jacksonville Jaguars at Cincinnati Bengals
• Projected Favorite: Jaguars (53.08% win probability)
• Spread: Cincinnati (-2.5)
• Total: 51.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. Jacksonville with FanDuel Sportsbook.

Eagles vs. Rams

The Los Angeles Rams (1-2) and the Philadelphia Eagles (2-1), who were both defeated in their last contest, will meet at 1 p.m. ET on Sunday, Oct. 4. In their previous games, the Rams lost 30-26 to the Broncos, and the Eagles were defeated by the Bears 27-7.

• Game Preview: Los Angeles Rams at Philadelphia Eagles
• Projected Favorite: Rams (56.12% win probability)
• Spread: Los Angeles (-3)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Los Angeles with FanDuel Sportsbook.

Giants vs. Cardinals

On Sunday, Oct. 4 at 1 p.m. ET, the Arizona Cardinals (1-2) will attempt to rebound from their recent 36-30 loss to the 49ers when they take on the New York Giants (2-1) at MetLife Stadium. The Giants won their last contest 12-7 against the Titans.

• Game Preview: Arizona Cardinals at New York Giants
• Projected Favorite: Cardinals (51.15% win probability)
• Spread: Arizona (-1.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Arizona with FanDuel Sportsbook.

Texans vs. Cowboys

The Houston Texans (0-3), who were defeated by the Colts in their previous contest, host the Dallas Cowboys (1-2) at NRG Stadium on Oct. 4 at 1 p.m. ET. The Cowboys took the L against the Ravens in their last game.

• Game Preview: Dallas Cowboys at Houston Texans
• Projected Favorite: Texans (60.85% win probability)
• Spread: Houston (-2.5)
• Total: 47.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Houston vs. Dallas with FanDuel Sportsbook.

Bears vs. Jets

After a 27-7 win over the Eagles in their last contest, the Chicago Bears (2-1) will host the New York Jets (1-2), who are coming off a 31-24 loss to the Lions. The game is set for 1 p.m. ET on Sunday, Oct. 4.

• Game Preview: New York Jets at Chicago Bears
• Projected Favorite: Bears (70.21% win probability)
• Spread: Chicago (-3.5)
• Total: 42.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. New York with FanDuel Sportsbook.

Buccaneers vs. Packers

The Green Bay Packers (1-2) and the Tampa Bay Buccaneers (0-3), who both lost their last contest, will match up at 1 p.m. ET on Sunday, Oct. 4. In their previous games, the Packers lost 35-14 to the Falcons, and the Buccaneers were defeated by the Vikings 23-16.

• Game Preview: Green Bay Packers at Tampa Bay Buccaneers
• Projected Favorite: Packers (60.43% win probability)
• Spread: Green Bay (-3.5)
• Total: 39.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. Green Bay with FanDuel Sportsbook.

Bills vs. Patriots

The NFL's top scoring team, the Buffalo Bills (3-0), hosts the New England Patriots (1-2) and their 31st-ranked scoring offense on Sunday, Oct. 4 at 1 p.m. ET. The Bills score 33.7 points per game, while the Patriots average 12.0 per game.

• Game Preview: New England Patriots at Buffalo Bills
• Projected Favorite: Bills (74.36% win probability)
• Spread: Buffalo (-6.5)
• Total: 48.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Buffalo vs. New England with FanDuel Sportsbook.

Vikings vs. Dolphins

With an offense that ranks 31st in the league at 12.0 points per game, the Miami Dolphins (0-3) have a tough road ahead against the Minnesota Vikings (3-0) and their second-ranked D (13.7 points surrendered per contest). The two teams match up at 4:05 p.m. ET on Oct. 4.

• Game Preview: Miami Dolphins at Minnesota Vikings
• Projected Favorite: Vikings (69.85% win probability)
• Spread: Minnesota (-10.5)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Minnesota vs. Miami with FanDuel Sportsbook.

Raiders vs. Chiefs

After clinching a 24-10 victory against the Dolphins in their last contest, the Kansas City Chiefs (3-0) will visit the Las Vegas Raiders (3-0), who are coming off a 35-27 win over the Saints, at Allegiant Stadium. Kickoff is scheduled for 4:25 p.m. ET on Sunday, Oct. 4.

• Game Preview: Kansas City Chiefs at Las Vegas Raiders
• Projected Favorite: Chiefs (64.95% win probability)
• Spread: Kansas City (-4.5)
• Total: 47.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Kansas City with FanDuel Sportsbook.

Seahawks vs. Chargers

Jaxon Smith-Njigba and the Seattle Seahawks (2-1) play the Los Angeles Chargers (0-3) on Sunday at 4:25 p.m. ET, at Lumen Field.

• Game Preview: Los Angeles Chargers at Seattle Seahawks
• Projected Favorite: Seahawks (74.75% win probability)
• Spread: Seattle (-7)
• Total: 43.5 -- Over: (-106) | Under: (-114)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Seattle vs. Los Angeles with FanDuel Sportsbook.

49ers vs. Broncos

After securing a 36-30 victory against the Cardinals in their previous contest, the San Francisco 49ers (3-0) will host the Denver Broncos (2-1), who are coming off a 30-26 win over the Rams, at Levi's Stadium. The game is set for 4:25 p.m. ET on Sunday, Oct. 4.

• Game Preview: Denver Broncos at San Francisco 49ers
• Projected Favorite: 49ers (65.20% win probability)
• Spread: San Francisco (-2.5)
• Total: 47.5 -- Over: (-112) | Under: (-108)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on San Francisco vs. Denver with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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