Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for AL Wild Card Game 2 on Sept. 30

Odds updated as of 12:11 a.m.

The Houston Astros versus the Chicago White Sox in Game 2 of the AL Wild Card Series is on the MLB schedule for Wednesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this game.

Astros vs White Sox Game Info

• Houston Astros (81-81) vs. Chicago White Sox (84-78)
• Date: Wednesday, September 30, 2026
• Time: 5 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: NBCSN and Peacock

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-144) | CHW: (+122)
• Spread: HOU: -1.5 (+158) | CHW: +1.5 (-192)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-4, 3.19 ERA vs Sean Burke (White Sox) - 11-7, 3.34 ERA

The probable starters are Hunter Brown (6-4, 3.19 ERA) for the Astros and Sean Burke (11-7, 3.34 ERA) for the White Sox. Brown and his team are 9-11-0 ATS this season when he starts. Brown's team has a record of 8-9 this season when he starts and they are the favorite on the moneyline. The White Sox have a 15-12-0 ATS record in Burke's 27 starts that had a set spread. The White Sox have a 6-9 record in Burke's 15 starts this season when they were the underdog on the moneyline.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (59.2%)

Astros vs White Sox Moneyline

• Houston is the favorite, -144 on the moneyline, while Chicago is a +122 underdog on the road.

Astros vs White Sox Spread

• The White Sox are at +1.5 on the runline against the Astros. The White Sox are -192 to cover the spread, and the Astros are +158.

Astros vs White Sox Over/Under

• The over/under for the Astros versus White Sox game on Sept. 30 has been set at 7.5, with -110 odds on the over and -110 odds on the under.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have come away with 38 wins in the 73 contests they have been listed as the favorites in this season.
• This year Houston has won 13 of 31 games when listed as at least -144 on the moneyline.
• Contests with the Astros have gone over the total set by sportsbooks in 81 of 163 chances this season.
• In 163 games with a line this season, the Astros have a mark of 82-81-0 against the spread.
• The White Sox have compiled a 51-55 record in games they were the underdog on the moneyline (winning 48.1% of those games).
• Chicago is 24-29 (winning 45.3% of its games) when it has played as a moneyline underdog of +122 or longer.
• The White Sox have had an over/under set by bookmakers 160 times, and have combined with opponents to go over the total in 90 of those games (90-69-1).
• The White Sox have a 91-69-0 record against the spread this season (covering 56.9% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston with 179 hits and an OBP of .432, plus a team-best slugging percentage of .601. He's batting .316.
• Among qualifying batters, he ranks first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Alvarez hopes to build on a 13-game hitting streak in this matchup. During his last 10 outings he is hitting .368 with three doubles, two home runs, six walks and seven RBIs.
• Isaac Paredes has 27 doubles, a triple, 25 home runs and 71 walks. He's batting .262 and slugging .447 with an on-base percentage of .360.
• His batting average ranks 56th among qualified players, his on-base percentage 30th, and his slugging percentage 49th.
• Christian Walker has collected 129 base hits, an OBP of .299 and a slugging percentage of .427 this season.
• Jeremy Pena has been key for Houston with 124 hits, an OBP of .325 plus a slugging percentage of .477.
• Pena takes a three-game hitting streak into this game. In his last five games he is batting .320 with two home runs and five RBIs.

White Sox Player Leaders

• Miguel Vargas is hitting .250 with 31 doubles, a triple, 33 home runs and 101 walks. He's slugging .474 with an on-base percentage of .363.
• Including all qualifying players in the majors, he ranks 79th in batting average, 24th in on-base percentage and 30th in slugging percentage.
• Chase Meidroth is slugging .415 to lead his team. He has a batting average of .276 with an on-base percentage of .350.
• He is currently 33rd in batting average, 45th in on-base percentage and 80th in slugging percentage among all qualified batters.
• Sam Antonacci has accumulated a team-high .370 on-base percentage.
• Munetaka Murakami paces his team with 94 hits.

Astros vs White Sox Head to Head

• 9/29/2026: 6-3 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/3/2026: 6-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/2/2026: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)

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