Astros vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for AL Wild Card Game 2 on Sept. 30

Odds updated as of 5:12 p.m.

The MLB slate on Wednesday includes the Houston Astros taking on the Chicago White Sox for Game 2 of the AL Wild Card Series.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs White Sox Game Info

• Houston Astros (81-81) vs. Chicago White Sox (84-78)
• Date: Wednesday, September 30, 2026
• Time: 5 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: NBCSN and Peacock

Astros vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-152) | CHW: (+128)
• Spread: HOU: -1.5 (+142) | CHW: +1.5 (-172)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Astros vs White Sox Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-4, 3.19 ERA vs Sean Burke (White Sox) - 11-7, 3.34 ERA

The probable pitchers are Hunter Brown (6-4, 3.19 ERA) for the Astros and Sean Burke (11-7, 3.34 ERA) for the White Sox. Brown and his team are 9-11-0 ATS this season when he starts. Brown's team has a record of 8-9 this season when he starts and they are the favorite on the moneyline. The White Sox are 15-12-0 against the spread when Burke starts. The White Sox have a 6-9 record in Burke's 15 starts this season when they were the underdog on the moneyline.

Astros vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.4%)

Astros vs White Sox Moneyline

• Looking at the moneyline for White Sox-Astros, Chicago is the underdog at +128, and Houston is -152 playing at home.

Astros vs White Sox Spread

• The Astros are hosting the White Sox and are favored by 1.5 runs (+142 to cover) on the runline. Chicago is -172 to cover.

Astros vs White Sox Over/Under

• An over/under of 7.5 has been set for Astros-White Sox on Sept. 30, with the over being -115 and the under -105.

Bet on Houston Astros vs. Chicago White Sox on FanDuel today!

Astros vs White Sox Betting Trends

• The Astros have been chosen as favorites in 73 games this year and have walked away with the win 38 times (52.1%) in those games.
• This season Houston has been victorious 11 times in 26 chances when named as a favorite of at least -152 on the moneyline.
• The Astros and their opponents have gone over the total this season in 81 of their 163 opportunities.
• The Astros are 82-81-0 against the spread in their 163 games with a line set by sportsbooks this season.
• The White Sox have won 48.1% of the games this season they were the underdog on the moneyline (51-55).
• Chicago has a record of 14-21 in games it has played as a moneyline underdog with odds of +128 or longer (40%).
• The White Sox have had an over/under set by bookmakers 160 times, and have combined with opponents to go over the total in 90 of those games (90-69-1).
• The White Sox have collected a 91-69-0 record against the spread this season (covering 56.9% of the time).

Astros Player Leaders

• Yordan Alvarez leads Houston with 179 hits and an OBP of .432, plus a team-best slugging percentage of .601. He's batting .316.
• Among all qualified hitters, he is first in batting average, his on-base percentage ranks first, and he is first in slugging.
• Alvarez will look for his 14th straight game with a hit in this contest. During his last 10 outings he is batting .368 with three doubles, two home runs, six walks and seven RBIs.
• Isaac Paredes is batting .262 with 27 doubles, a triple, 25 home runs and 71 walks, while slugging .447 with an on-base percentage of .360.
• He is 56th in batting average, 30th in on-base percentage and 49th in slugging among qualified hitters.
• Christian Walker has collected 129 base hits, an OBP of .299 and a slugging percentage of .427 this season.
• Jeremy Pena is batting .277 with a .325 OBP and 56 RBI for Houston this season.
• Pena heads into this game on a three-game hitting streak. During his last five outings he is hitting .320 with two home runs and five RBIs.

White Sox Player Leaders

• Miguel Vargas is hitting .250 with 31 doubles, a triple, 33 home runs and 101 walks. He's slugging .474 with an on-base percentage of .363.
• Including all qualifying players in the big leagues, he ranks 79th in batting average, 24th in on-base percentage and 30th in slugging percentage.
• Chase Meidroth leads his team with a .415 slugging percentage. He has a batting average of .276 with an on-base percentage of .350.
• Including all qualifying hitters, he is 33rd in batting average, 45th in on-base percentage and 80th in slugging percentage.
• Sam Antonacci a has .370 on-base percentage to pace the White Sox.
• Munetaka Murakami has collected 94 hits to lead his team.

Astros vs White Sox Head to Head

• 9/29/2026: 6-3 CHW (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/3/2026: 6-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/2/2026: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/1/2026: 5-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2026: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +118)
• 7/26/2026: 12-3 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/25/2026: 4-1 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/24/2026: 9-5 HOU (Favorite: White Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/12/2025: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -275, Underdog Moneyline: +225)
• 6/11/2025: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)

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