NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 2

The matchups in a Week 2 NFL schedule that shouldn't be missed include the Seattle Seahawks playing the Arizona Cardinals at State Farm Stadium.

Here are the betting odds to analyze before Week 2 in the NFL.

Bills vs. Lions

On Thursday at 8:15 p.m. ET, a pair of star pass-catchers will be on display when Dalton Kincaid and the Buffalo Bills (1-0) host Amon-Ra St. Brown and the Detroit Lions (1-0).

• Game Preview: Detroit Lions at Buffalo Bills
• Projected Favorite: Bills (64.14% win probability)
• Spread: Buffalo (-4.5)
• Total: 53.5 -- Over: (-115) | Under: (-105)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Buffalo vs. Detroit with FanDuel Sportsbook.

Falcons vs. Panthers

At Mercedes-Benz Stadium on Sunday, Jalen Coker and the Carolina Panthers (0-1) face Bijan Robinson and the Atlanta Falcons (0-1) in a matchup featuring two of the brightest stars in football, starting at 1 p.m. ET.

• Game Preview: Carolina Panthers at Atlanta Falcons
• Projected Favorite: Panthers (53.03% win probability)
• Spread: Carolina (-2.5)
• Total: 43.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Atlanta vs. Carolina with FanDuel Sportsbook.

Patriots vs. Steelers

The Pittsburgh Steelers (1-0) play on Sunday at 1 p.m. ET at Gillette Stadium against the New England Patriots (0-1).

• Game Preview: Pittsburgh Steelers at New England Patriots
• Projected Favorite: Patriots (70.73% win probability)
• Spread: New England (-4.5)
• Total: 42.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. Pittsburgh with FanDuel Sportsbook.

Buccaneers vs. Browns

At 1 p.m. ET on Sunday, the Tampa Bay Buccaneers (0-1) are at home against the Cleveland Browns (0-1).

• Game Preview: Cleveland Browns at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (67.77% win probability)
• Spread: Tampa Bay (-8.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tampa Bay vs. Cleveland with FanDuel Sportsbook.

Jets vs. Packers

One of the best pass-catchers in football will be on show when Christian Watson and the Green Bay Packers (0-1) visit the New York Jets (1-0) on Sunday, September 20, 2026.

• Game Preview: Green Bay Packers at New York Jets
• Projected Favorite: Packers (64.04% win probability)
• Spread: Green Bay (-3.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Green Bay with FanDuel Sportsbook.

Ravens vs. Saints

On Sunday at 1 p.m. ET, two of the best offensive performers in football will be on display when running back Derrick Henry and the Baltimore Ravens (1-0) host QB Tyler Shough and the New Orleans Saints (0-1).

• Game Preview: New Orleans Saints at Baltimore Ravens
• Projected Favorite: Ravens (72.49% win probability)
• Spread: Baltimore (-8.5)
• Total: 46.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. New Orleans with FanDuel Sportsbook.

Titans vs. Eagles

One of the best pass-catchers in football will be on display when Dallas Goedert and the Philadelphia Eagles (1-0) visit the Tennessee Titans (0-1) on Sunday, September 20, 2026.

• Game Preview: Philadelphia Eagles at Tennessee Titans
• Projected Favorite: Eagles (73.15% win probability)
• Spread: Philadelphia (-7)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tennessee vs. Philadelphia with FanDuel Sportsbook.

Bears vs. Vikings

The Chicago Bears (1-0) and the Minnesota Vikings (1-0), who both won their last game, will square off at 1 p.m. ET on Sunday, Sept. 20. In their previous games, the Bears won 59-37 against the Panthers, and the Vikings took down the Packers 39-22.

• Game Preview: Minnesota Vikings at Chicago Bears
• Projected Favorite: Bears (69.42% win probability)
• Spread: Chicago (-5.5)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. Minnesota with FanDuel Sportsbook.

Texans vs. Bengals

On Sunday, Sept. 20 at 1 p.m. ET, the Houston Texans (0-1) will attempt to bounce back from their recent 36-31 loss to the Bills when they go head to head against the Cincinnati Bengals (1-0) at NRG Stadium. The Bengals won their previous tilt 33-27 versus the Buccaneers.

• Game Preview: Cincinnati Bengals at Houston Texans
• Projected Favorite: Texans (73.51% win probability)
• Spread: Houston (-3)
• Total: 46.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Cincinnati with FanDuel Sportsbook.

Chargers vs. Raiders

Ashton Jeanty and the Las Vegas Raiders (1-0) meet the Los Angeles Chargers (0-1) on Sunday at 4:05 p.m. ET at SoFi Stadium.

• Game Preview: Las Vegas Raiders at Los Angeles Chargers
• Projected Favorite: Chargers (77.67% win probability)
• Spread: Los Angeles (-6.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Los Angeles vs. Las Vegas with FanDuel Sportsbook.

Broncos vs. Jaguars

After losing 31-10 to the Chiefs in their previous game, the Denver Broncos (0-1) will host the Jacksonville Jaguars (1-0), who are coming off a 34-10 victory over the Browns. The game is scheduled for 4:05 p.m. ET on Sunday, Sept. 20.

• Game Preview: Jacksonville Jaguars at Denver Broncos
• Projected Favorite: Broncos (55.42% win probability)
• Spread: Denver (-2.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Denver vs. Jacksonville with FanDuel Sportsbook.

Cowboys vs. Commanders

The Washington Commanders (0-1) will visit the Dallas Cowboys (0-1) on Sunday at 4:25 p.m. ET.

• Game Preview: Washington Commanders at Dallas Cowboys
• Projected Favorite: Cowboys (62.99% win probability)
• Spread: Dallas (-3.5)
• Total: 50.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Dallas vs. Washington with FanDuel Sportsbook.

49ers vs. Dolphins

The San Francisco 49ers (1-0) are scheduled to match up with the Miami Dolphins (0-1) at Levi's Stadium on Sunday, Sept. 20 at 4:25 p.m. ET. In their last tilts, the 49ers took down the Rams 27-7, and the Dolphins lost 27-13 to the Raiders.

• Game Preview: Miami Dolphins at San Francisco 49ers
• Projected Favorite: 49ers (77.10% win probability)
• Spread: San Francisco (-13.5)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Miami with FanDuel Sportsbook.

Cardinals vs. Seahawks

The Seattle Seahawks (1-0) are slated to match up with the Arizona Cardinals (1-0) at State Farm Stadium on Sunday, Sept. 20 at 4:25 p.m. ET. Both squads won their last tilt, as the Seahawks defeated the Patriots 13-10, and the Cardinals won 26-14 versus the Chargers.

• Game Preview: Seattle Seahawks at Arizona Cardinals
• Projected Favorite: Seahawks (65.46% win probability)
• Spread: Seattle (-4.5)
• Total: 41.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Arizona vs. Seattle with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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