Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 2:12 a.m.

The Cleveland Guardians are among the MLB teams playing on Wednesday, versus the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Guardians vs White Sox Game Info

• Cleveland Guardians (77-75) vs. Chicago White Sox (77-74)
• Date: Wednesday, September 16, 2026
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: ESPN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-172) | CHW: (+144)
• Spread: CLE: -1.5 (+128) | CHW: +1.5 (-154)
• Total: 7.5 -- Over: (-122) | Under: (+100)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 11-9, 2.51 ERA vs Anthony Kay (White Sox) - 9-9, 4.59 ERA

The Guardians will give the nod to Parker Messick (11-9) versus the White Sox and Anthony Kay (9-9). When Messick starts, his team is 15-14-0 against the spread this season. Messick's team has been victorious in 47.8% of the games he's started as the moneyline favorite with a record of 11-12. The White Sox have an 18-9-0 ATS record in Kay's 27 starts that had a set spread. The White Sox have a 13-9 record in Kay's 22 starts this season when they were the underdog on the moneyline.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.1%)

Guardians vs White Sox Moneyline

• The moneyline numbers for Guardians vs. White Sox reveal Cleveland as the favorite (-172) and Chicago as the underdog (+144) on the road.

Guardians vs White Sox Spread

• The Guardians are 1.5-run home favorites on the runline against the White Sox. The Guardians are +128 to cover, and the White Sox are -154.

Guardians vs White Sox Over/Under

• The over/under for the Guardians versus White Sox game on Sept. 16 has been set at 7.5, with -122 odds on the over and +100 odds on the under.

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Guardians vs White Sox Betting Trends

• The Guardians have won in 44, or 51.2%, of the 86 contests they have been named as odds-on favorites in this year.
• This season Cleveland has been victorious six times in 10 chances when named as a favorite of at least -172 on the moneyline.
• The Guardians and their opponents have hit the over in 71 of their 144 games with a total set by oddsmakers this season.
• The Guardians are 67-77-0 against the spread in their 144 games that had a posted line this season.
• The White Sox have been the underdog on the moneyline 104 total times this season. They've finished 50-54 in those games.
• Chicago has a record of 5-10 when playing as a moneyline underdog with odds of +144 or longer (33.3%).
• The White Sox have played in 148 games with a set over/under, and have combined with their opponents to go over the total 82 times (82-65-1).
• The White Sox have an 83-65-0 record against the spread this season (covering 56.1% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (134) this season while batting .289 with 45 extra-base hits. He has an on-base percentage of .362 and a slugging percentage of .453.
• He is 12th in batting average, 26th in on-base percentage, and 46th in slugging among qualifying batters in MLB.
• Steven Kwan is slashing .279/.376/.346 this season and leads the Guardians with an OPS of .722.
• Among qualifying hitters, his batting average places him 25th, his on-base percentage 10th, and his slugging percentage 133rd.
• Kwan heads into this matchup looking to extend his nine-game hit streak. During his last 10 outings he is hitting .350 with four doubles, a home run, four walks and three RBIs.
• Jose Ramirez is batting .228 with a .359 slugging percentage and 48 RBI this year.
• Brayan Rocchio has 13 home runs, 67 RBI and a batting average of .249 this season.
• Rocchio brings a three-game hitting streak into this game. In his last five games he is hitting .313 with two doubles, two walks and five RBIs.

White Sox Player Leaders

• Miguel Vargas has put up 138 hits, a team-high for the White Sox. He's batting .249 and slugging .475 with an on-base percentage of .358.
• Including all the qualifying hitters in the majors, he is 82nd in batting average, 34th in on-base percentage and 28th in slugging percentage.
• Vargas heads into this game on a five-game hitting streak. During his last five outings he is hitting .286 with a home run, two walks and five RBIs.
• Chase Meidroth is slugging .399 to pace his team. He has a batting average of .268 with an on-base percentage of .344.
• Including all qualifying hitters, he is 49th in batting average, 50th in on-base percentage and 93rd in slugging percentage.
• Sam Antonacci a has .367 on-base percentage to pace the White Sox.
• Tristan Peters is batting .275 with 31 doubles, four triples, 12 home runs and 36 walks.

Guardians vs White Sox Head to Head

• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/23/2026: 2-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)

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