NFL Games This Sunday: Predictions, Odds, Picks, Best Bets for Week 6

On a Week 6 NFL Sunday slate that has plenty of thrilling contests, the Chicago Bears versus the Atlanta Falcons is a game to catch.

With Sunday upon us in Week 6 of the NFL season, stay on top of the most current betting trends with our preview below.

Jaguars vs. Texans

The Jacksonville Jaguars (4-1) and their 23rd-ranked pass defense might struggle to slow down the Houston Texans (1-4) and C.J. Stroud, one of the league's top passers, when the Jaguars host the Texans at Wembley Stadium on Oct. 18 at 9:30 a.m. ET.

• Game Preview: Houston Texans vs. Jacksonville Jaguars
• Projected Favorite: Jaguars (60.81% win probability)
• Spread: Jacksonville (-2.5)
• Total: 42.5 -- Over: (-108) | Under: (-112)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Jacksonville vs. Houston with FanDuel Sportsbook.

Patriots vs. Jets

Garrett Wilson and the New York Jets (2-3) play the New England Patriots (3-2) on Sunday at 1 p.m. ET at Gillette Stadium.

• Game Preview: New York Jets at New England Patriots
• Projected Favorite: Patriots (86.88% win probability)
• Spread: New England (-7.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. New York with FanDuel Sportsbook.

Eagles vs. Panthers

Lincoln Financial Field is the venue where the Carolina Panthers (2-2) will battle the Philadelphia Eagles (2-3) on Sunday, October 18, 2026.

• Game Preview: Carolina Panthers at Philadelphia Eagles
• Projected Favorite: Panthers (63.40% win probability)
• Spread: Carolina (-1.5)
• Total: 39.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Philadelphia vs. Carolina with FanDuel Sportsbook.

Giants vs. Saints

Chris Olave will lead the New Orleans Saints (1-4) into their battle versus the New York Giants (3-1-1) at MetLife Stadium on Sunday at 1 p.m. ET.

• Game Preview: New Orleans Saints at New York Giants
• Projected Favorite: Giants (53.72% win probability)
• Spread: New Orleans (-1.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. New Orleans with FanDuel Sportsbook.

Colts vs. Titans

The Indianapolis Colts (2-3) are slated to square off against the Tennessee Titans (0-5) at Lucas Oil Stadium on Sunday, Oct. 18 at 1 p.m. ET. Both squads lost their previous contest, as the Colts were taken down by the Steelers 34-22, and the Titans lost 26-3 to the Texans.

• Game Preview: Tennessee Titans at Indianapolis Colts
• Projected Favorite: Colts (78.56% win probability)
• Spread: Indianapolis (-6.5)
• Total: 43.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Indianapolis vs. Tennessee with FanDuel Sportsbook.

Falcons vs. Bears

D'Andre Swift and the Chicago Bears (3-2) will get a stiff test when they collide with the Atlanta Falcons (2-3), who own the league's fourth-best run D, on Sunday, Oct. 18 at 1 p.m. ET. Swift ranks 10th-best in the NFL in rushing yards.

• Game Preview: Chicago Bears at Atlanta Falcons
• Projected Favorite: Bears (54.22% win probability)
• Spread: Chicago (-1.5)
• Total: 50.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Atlanta vs. Chicago with FanDuel Sportsbook.

Buccaneers vs. Steelers

The 1 p.m. ET tilt on Oct. 18 between the Pittsburgh Steelers (3-2) and the Tampa Bay Buccaneers (1-4) should be a fun matchup, as Jaylen Warren has been one of the NFL's top rushers this year, and the Buccaneers have a top-five run defense, ranking second-best in the NFL at 72.8 rushing yards surrendered per contest.

• Game Preview: Pittsburgh Steelers at Tampa Bay Buccaneers
• Projected Favorite: Steelers (54.21% win probability)
• Spread: Pittsburgh (-2.5)
• Total: 39.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tampa Bay vs. Pittsburgh with FanDuel Sportsbook.

Browns vs. Ravens

Zay Flowers and the Baltimore Ravens (4-1) meet the Cleveland Browns (3-2) on Sunday at 1 p.m. ET, at Huntington Bank Field.

• Game Preview: Baltimore Ravens at Cleveland Browns
• Projected Favorite: Ravens (61.40% win probability)
• Spread: Baltimore (-5.5)
• Total: 42.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Baltimore with FanDuel Sportsbook.

Rams vs. Cardinals

When the Los Angeles Rams (2-3) and the Arizona Cardinals (1-4) match up on Sunday, Oct. 18 at 4:05 p.m. ET, they will both be aiming to bounce back after losing their last tilt. The Rams lost 37-34 to the Bills, and the Cardinals are coming off a 45-21 loss to the Lions.

• Game Preview: Arizona Cardinals at Los Angeles Rams
• Projected Favorite: Rams (89.63% win probability)
• Spread: Los Angeles (-12.5)
• Total: 51.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Arizona with FanDuel Sportsbook.

Chiefs vs. Chargers

Star running back Kenneth Walker III and the Kansas City Chiefs (4-0) face the Los Angeles Chargers (0-5) on Sunday at 4:25 p.m. ET at GEHA Field at Arrowhead Stadium.

• Game Preview: Los Angeles Chargers at Kansas City Chiefs
• Projected Favorite: Chiefs (86.15% win probability)
• Spread: Kansas City (-8.5)
• Total: 42.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Kansas City vs. Los Angeles with FanDuel Sportsbook.

Raiders vs. Bills

On Sunday at 4:25 p.m. ET, two of the best offensive performers in football will be featured when quarterback Josh Allen and the Buffalo Bills (4-1) visit pass-catcher Brock Bowers and the Las Vegas Raiders (3-2).

• Game Preview: Buffalo Bills at Las Vegas Raiders
• Projected Favorite: Bills (68.45% win probability)
• Spread: Buffalo (-5.5)
• Total: 53.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Las Vegas vs. Buffalo with FanDuel Sportsbook.

Packers vs. Cowboys

CeeDee Lamb, who ranks third-best in the NFL in receiving yards, will aim to lead the way for the Dallas Cowboys (2-3) on Oct. 18 at 8:20 p.m. ET, when they visit the Green Bay Packers (3-2) and their fifth-best pass defense (181.0 passing yards allowed per game).

• Game Preview: Dallas Cowboys at Green Bay Packers
• Projected Favorite: Packers (64.11% win probability)
• Spread: Green Bay (-1.5)
• Total: 52.5 -- Over: (-112) | Under: (-108)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Green Bay vs. Dallas with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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