Nationals vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 2:14 a.m.

The MLB slate on Saturday includes the Washington Nationals facing the St. Louis Cardinals.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Nationals vs Cardinals Game Info

• Washington Nationals (72-82) vs. St. Louis Cardinals (75-79)
• Date: Saturday, September 19, 2026
• Time: 7:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and Nationals.TV

Nationals vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-110) | STL: (-106)
• Spread: WSH: -1.5 (+158) | STL: +1.5 (-192)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Nationals vs Cardinals Probable Starting Pitchers

Probable Pitchers: Andrew Alvarez (Nationals) - 2-6, 3.35 ERA vs Michael McGreevy (Cardinals) - 7-9, 3.83 ERA

This contest's pitching matchup is set, as the Nationals will send Andrew Alvarez (2-6) to the mound, while Michael McGreevy (7-9) will answer the bell for the Cardinals. Alvarez's team is 5-10-0 against the spread this season in his starts. When Alvarez starts a game and his team is the favorite on the moneyline, they have a record of 3-3. When McGreevy starts, the Cardinals are 17-12-0 against the spread. The Cardinals have been the underdog on the moneyline in 21 of McGreevy's starts this season, and they went 11-10 in those games.

Nationals vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (53.9%)

Nationals vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Nationals, St. Louis is the underdog at -106, and Washington is -110 playing on the road.

Nationals vs Cardinals Spread

• The Nationals are favored by 1.5 runs on the road against the Cardinals. The Nationals are +158 to cover the spread, while the Cardinals are -192.

Nationals vs Cardinals Over/Under

• The over/under for the Nationals versus Cardinals contest on Sept. 19 has been set at 7.5, with -114 odds on the over and -106 odds on the under.

Bet on Washington Nationals vs. St. Louis Cardinals on FanDuel today!

Nationals vs Cardinals Betting Trends

• The Nationals have been chosen as favorites in 32 games this year and have walked away with the win 18 times (56.2%) in those games.
• Washington has a record of 18-14 when favored by -110 or more this year.
• The Nationals and their opponents have hit the over in 79 of their 150 games with a total set by oddsmakers this season.
• The Nationals have an against the spread mark of 82-68-0 in 150 games with a line this season.
• The Cardinals have put together a 45-52 record in games they were the underdog on the moneyline (winning 46.4% of those games).
• St. Louis has a 45-50 record (winning 47.4% of its games) when playing as a moneyline underdog of -106 or longer.
• The Cardinals have had an over/under set by bookmakers 150 times, and have combined with opponents to go over the total in 70 of those games (70-73-7).
• The Cardinals have an 80-70-0 record ATS this season.

Nationals Player Leaders

• C.J. Abrams has an OPS of .831, fueled by an OBP of .338 and a team-best slugging percentage of .493 this season. He has a .264 batting average.
• Among the qualifying hitters in MLB, his batting average ranks 55th, his on-base percentage ranks 57th, and he is 18th in slugging.
• Abrams hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .381 with four doubles and two RBIs.
• James Wood has 128 hits and an OBP of .392, both of which lead the Nationals this season. He's batting .266 and slugging .519.
• Among all qualifying players, he ranks 52nd in batting average, third in on-base percentage and ninth in slugging percentage.
• Daylen Lile has collected 143 base hits, an OBP of .303 and a slugging percentage of .435 this season.
• Jacob Young is batting .248 with a .317 OBP and 47 RBI for Washington this season.

Cardinals Player Leaders

• Alec Burleson has put up a team-best .469 slugging percentage. He's batting .283 with an on-base percentage of .349.
• Including all qualified hitters in MLB, his batting average puts him 17th, his on-base percentage is 43rd, and he is 32nd in slugging.
• Jordan Walker's 161 hits lead his team. He has a batting average of .279 while slugging .481 with an on-base percentage of .336.
• His batting average is 24th among all qualified players, his on-base percentage is 60th, and he is 26th in slugging.
• Ivan Herrera a has .355 on-base percentage to pace the Cardinals.
• JJ Wetherholt has 14 doubles, 17 home runs and 63 walks while hitting .240.

Nationals vs Cardinals Head to Head

• 9/18/2026: 9-1 WSH (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/8/2026: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/7/2026: 7-6 STL (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2026: 9-6 WSH (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2025: 8-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/9/2025: 8-2 WSH (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/11/2025: 6-1 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/10/2025: 4-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/9/2025: 10-0 STL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 7/28/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)

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