Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 19

Odds updated as of 1:11 a.m.

The MLB slate on Saturday includes the Chicago Cubs taking on the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Reds Game Info

• Chicago Cubs (85-69) vs. Cincinnati Reds (72-82)
• Date: Saturday, September 19, 2026
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-134) | CIN: (+114)
• Spread: CHC: -1.5 (+118) | CIN: +1.5 (-142)
• Total: 9.5 -- Over: (-112) | Under: (-108)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 8-5, 4.16 ERA vs Nick Lodolo (Reds) - 3-5, 5.12 ERA

The Cubs will give the nod to Matthew Boyd (8-5) versus the Reds and Nick Lodolo (3-5). Boyd's team is 9-10-0 against the spread this season in his starts. When Boyd starts a game and his team is the favorite on the moneyline, they have a record of 8-5. When Lodolo starts, the Reds have gone 8-11-0 against the spread. The Reds have been the underdog on the moneyline in 14 of Lodolo's starts this season, and they went 6-8 in those games.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (63.2%)

Cubs vs Reds Moneyline

• The moneyline numbers for Cubs vs. Reds reveal Chicago as the favorite (-134) and Cincinnati as the underdog (+114) despite being the home team.

Cubs vs Reds Spread

• The Reds are +1.5 on the run line against the Cubs. The Reds are -142 to cover, and the Cubs are +118.

Cubs vs Reds Over/Under

• An over/under of 9.5 has been set for Cubs-Reds on Sept. 19, with the over being -112 and the under -108.

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Cubs vs Reds Betting Trends

• The Cubs have been chosen as favorites in 101 games this year and have walked away with the win 57 times (56.4%) in those games.
• This season Chicago has been victorious 36 times in 64 chances when named as a favorite of at least -134 on the moneyline.
• The Cubs' games have gone over the total in 85 of their 149 opportunities.
• The Cubs are 71-78-0 against the spread in their 149 games that had a posted line this season.
• The Reds have won 50 of the 106 games they were the moneyline underdog this season (47.2%).
• In games it has played as a moneyline underdog with odds of +114 or longer, Cincinnati has a record of 28-36 (43.8%).
• In the 150 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 80 times (80-68-2).
• The Reds have a 77-73-0 record ATS this season (covering 51.3% of the time).

Cubs Player Leaders

• Pete Crow-Armstrong has 167 hits and an OBP of .372 to go with a slugging percentage of .576. All three of those stats are tops among Chicago hitters this season. He has a .280 batting average, as well.
• He ranks 23rd in batting average, 13th in on-base percentage, and second in slugging among all qualified hitters in baseball.
• Alex Bregman is hitting .262 with 32 doubles, two triples, 26 home runs and 73 walks. He's slugging .454 with an on-base percentage of .351.
• Among qualified hitters, his batting average ranks him 59th, his on-base percentage 40th, and his slugging percentage 41st.
• Seiya Suzuki is batting .265 with a .466 slugging percentage and 83 RBI this year.
• Nico Hoerner has eight home runs, 69 RBI and a batting average of .263 this season.

Reds Player Leaders

• Sal Stewart has racked up a team-high .476 slugging percentage. He's batting .271 with an on-base percentage of .338.
• Including all qualifying hitters, he is 42nd in batting average, while his on-base percentage ranks 57th and he is 30th in slugging.
• Stewart brings a three-game hitting streak into this game. During his last five outings he is hitting .316 with a home run and three RBIs.
• Elly De La Cruz has racked up 152 hits with a .366 OBP to pace his team in both. He has a batting average of .287 while slugging .519.
• Including all qualifying hitters, he ranks 13th in batting average, 20th in on-base percentage and ninth in slugging percentage.
• JJ Bleday is hitting .214 with 16 doubles, two triples, 22 home runs and 70 walks.
• Tyler Stephenson has 21 doubles, 15 home runs and 48 walks while hitting .248.

Cubs vs Reds Head to Head

• 9/18/2026: 6-4 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/30/2026: 7-5 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +142)
• 8/29/2026: 17-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -205, Underdog Moneyline: +190)
• 8/28/2026: 10-8 CIN (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +176)
• 7/12/2026: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/11/2026: 5-3 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/10/2026: 4-0 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/7/2026: 8-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/6/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/5/2026: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

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