Wednesday’s MLB Home Run Props - May 21

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Will José Ramírez or Kyle Manzardo hit a home run on Wednesday? See their odds to hit a home run, as well as home run prop odds for all hitters in MLB play on May 21, in the article below.

Today's MLB Home Run Props

Cleveland Guardians at Minnesota Twins

José Ramírez (Guardians): +420 to hit a HR | 2025 Stats: 9 HR in 44 games (has homered in 15.9% of games)
Kyle Manzardo (Guardians): +420 to hit a HR | 2025 Stats: 10 HR in 41 games (has homered in 24.4% of games)
Bo Naylor (Guardians): +460 to hit a HR | 2025 Stats: 6 HR in 35 games (has homered in 17.1% of games)
Ryan Jeffers (Twins): +460 to hit a HR | 2025 Stats: 3 HR in 35 games (has homered in 8.6% of games)
Carlos Santana (Guardians): +470 to hit a HR | 2025 Stats: 4 HR in 44 games (has homered in 9.1% of games)
Royce Lewis (Twins): +540 to hit a HR | 2025 Stats: 1 HR in 12 games (has homered in 8.3% of games)
Carson McCusker (Twins): +560 to hit a HR | 2025 Stats: 0 HR in 1 game
Harrison Bader (Twins): +560 to hit a HR | 2025 Stats: 4 HR in 38 games (has homered in 10.5% of games)
Ty France (Twins): +600 to hit a HR | 2025 Stats: 3 HR in 46 games (has homered in 6.5% of games)
Brooks Lee (Twins): +630 to hit a HR | 2025 Stats: 4 HR in 31 games (has homered in 12.9% of games)
Trevor Larnach (Twins): +750 to hit a HR | 2025 Stats: 7 HR in 46 games (has homered in 15.2% of games)
Angel Martinez (Guardians): +830 to hit a HR | 2025 Stats: 1 HR in 32 games (has homered in 3.1% of games)
Gabriel Arias (Guardians): +870 to hit a HR | 2025 Stats: 4 HR in 42 games (has homered in 9.5% of games)
Nolan Jones (Guardians): +900 to hit a HR | 2025 Stats: 2 HR in 40 games (has homered in 5% of games)
Jonah Bride (Twins): +1000 to hit a HR | 2025 Stats: 0 HR in 26 games
Willi Castro (Twins): +1000 to hit a HR | 2025 Stats: 2 HR in 28 games (has homered in 7.1% of games)
Steven Kwan (Guardians): +1100 to hit a HR | 2025 Stats: 4 HR in 46 games (has homered in 8.7% of games)
Will Brennan (Guardians): +1300 to hit a HR | 2025 Stats: 0 HR in 5 games
DaShawn Keirsey Jr. (Twins): +10000 to hit a HR | 2025 Stats: 1 HR in 17 games (has homered in 5.9% of games)
Byron Buxton (Twins): +10000 to hit a HR | 2025 Stats: 10 HR in 41 games (has homered in 24.4% of games)
Kody Clemens (Twins): +10000 to hit a HR | 2025 Stats: 3 HR in 21 games (has homered in 14.3% of games)
Daniel Schneemann (Guardians): +10000 to hit a HR | 2025 Stats: 6 HR in 34 games (has homered in 14.7% of games)

Texas Rangers at New York Yankees

Aaron Judge (Yankees): +265 to hit a HR | 2025 Stats: 16 HR in 47 games (has homered in 27.7% of games)
Wyatt Langford (Rangers): +470 to hit a HR | 2025 Stats: 9 HR in 39 games (has homered in 23.1% of games)
Jake Burger (Rangers): +500 to hit a HR | 2025 Stats: 4 HR in 38 games (has homered in 10.5% of games)
Ben Rice (Yankees): +520 to hit a HR | 2025 Stats: 10 HR in 41 games (has homered in 22% of games)
Adolis Garcia (Rangers): +520 to hit a HR | 2025 Stats: 6 HR in 48 games (has homered in 12.5% of games)
Josh Jung (Rangers): +600 to hit a HR | 2025 Stats: 7 HR in 40 games (has homered in 15% of games)
Jasson Domínguez (Yankees): +600 to hit a HR | 2025 Stats: 5 HR in 39 games (has homered in 7.7% of games)
Paul Goldschmidt (Yankees): +630 to hit a HR | 2025 Stats: 5 HR in 47 games (has homered in 10.6% of games)
Kevin Pillar (Rangers): +630 to hit a HR | 2025 Stats: 0 HR in 18 games
Cody Bellinger (Yankees): +680 to hit a HR | 2025 Stats: 7 HR in 43 games (has homered in 16.3% of games)
Jonah Heim (Rangers): +750 to hit a HR | 2025 Stats: 6 HR in 37 games (has homered in 13.5% of games)
Austin Wells (Yankees): +750 to hit a HR | 2025 Stats: 8 HR in 40 games (has homered in 20% of games)
Oswald Peraza (Yankees): +830 to hit a HR | 2025 Stats: 2 HR in 23 games (has homered in 8.7% of games)
Marcus Semien (Rangers): +830 to hit a HR | 2025 Stats: 3 HR in 48 games (has homered in 6.3% of games)
Josh Smith (Rangers): +870 to hit a HR | 2025 Stats: 4 HR in 39 games (has homered in 10.3% of games)
Anthony Volpe (Yankees): +1000 to hit a HR | 2025 Stats: 6 HR in 46 games (has homered in 13% of games)
Jorbit Vivas (Yankees): +1100 to hit a HR | 2025 Stats: 0 HR in 13 games
Sam Haggerty (Rangers): +1100 to hit a HR | 2025 Stats: 0 HR in 8 games
Ezequiel Duran (Rangers): +10000 to hit a HR | 2025 Stats: 0 HR in 12 games
DJ LeMahieu (Yankees): +10000 to hit a HR | 2025 Stats: 1 HR in 5 games (has homered in 20% of games)
Joc Pederson (Rangers): +10000 to hit a HR | 2025 Stats: 2 HR in 42 games (has homered in 4.8% of games)
Oswaldo Cabrera (Yankees): +10000 to hit a HR | 2025 Stats: 1 HR in 33 games (has homered in 3% of games)
Trent Grisham (Yankees): +10000 to hit a HR | 2025 Stats: 12 HR in 38 games (has homered in 26.3% of games)

Arizona Diamondbacks at Los Angeles Dodgers

Shohei Ohtani (Dodgers): +210 to hit a HR | 2025 Stats: 17 HR in 46 games (has homered in 34.8% of games)
Ketel Marte (Diamondbacks): +285 to hit a HR | 2025 Stats: 6 HR in 24 games (has homered in 16.7% of games)
Corbin Carroll (Diamondbacks): +310 to hit a HR | 2025 Stats: 14 HR in 48 games (has homered in 22.9% of games)
Eugenio Suárez (Diamondbacks): +320 to hit a HR | 2025 Stats: 14 HR in 48 games (has homered in 20.8% of games)
Andy Pages (Dodgers): +400 to hit a HR | 2025 Stats: 9 HR in 44 games (has homered in 20.5% of games)
Freddie Freeman (Dodgers): +420 to hit a HR | 2025 Stats: 9 HR in 37 games (has homered in 24.3% of games)
Mookie Betts (Dodgers): +430 to hit a HR | 2025 Stats: 8 HR in 45 games (has homered in 13.3% of games)
Max Muncy (Dodgers): +450 to hit a HR | 2025 Stats: 3 HR in 45 games (has homered in 6.7% of games)
Teoscar Hernandez (Dodgers): +460 to hit a HR | 2025 Stats: 9 HR in 34 games (has homered in 23.5% of games)
Josh Naylor (Diamondbacks): +500 to hit a HR | 2025 Stats: 5 HR in 47 games (has homered in 10.6% of games)
Lourdes Gurriel Jr. (Diamondbacks): +520 to hit a HR | 2025 Stats: 8 HR in 44 games (has homered in 18.2% of games)
Pavin Smith (Diamondbacks): +540 to hit a HR | 2025 Stats: 4 HR in 44 games (has homered in 9.1% of games)
Michael Conforto (Dodgers): +600 to hit a HR | 2025 Stats: 2 HR in 45 games (has homered in 4.4% of games)
Tommy Edman (Dodgers): +600 to hit a HR | 2025 Stats: 8 HR in 32 games (has homered in 25% of games)
Alek Thomas (Diamondbacks): +830 to hit a HR | 2025 Stats: 1 HR in 38 games (has homered in 2.6% of games)
Gabriel Moreno (Diamondbacks): +900 to hit a HR | 2025 Stats: 2 HR in 36 games (has homered in 5.6% of games)
Geraldo Perdomo (Diamondbacks): +1000 to hit a HR | 2025 Stats: 6 HR in 47 games (has homered in 12.8% of games)
Will Smith (Dodgers): +10000 to hit a HR | 2025 Stats: 4 HR in 39 games (has homered in 10.3% of games)

San Diego Padres at Toronto Blue Jays

Fernando Tatis Jr. (Padres): +310 to hit a HR | 2025 Stats: 12 HR in 45 games (has homered in 24.4% of games)
Daulton Varsho (Blue Jays): +420 to hit a HR | 2025 Stats: 6 HR in 14 games (has homered in 35.7% of games)
Anthony Santander (Blue Jays): +420 to hit a HR | 2025 Stats: 6 HR in 42 games (has homered in 14.3% of games)
Vladimir Guerrero Jr. (Blue Jays): +430 to hit a HR | 2025 Stats: 6 HR in 47 games (has homered in 12.8% of games)
Manny Machado (Padres): +450 to hit a HR | 2025 Stats: 3 HR in 46 games (has homered in 6.5% of games)
Jackson Merrill (Padres): +450 to hit a HR | 2025 Stats: 4 HR in 21 games (has homered in 19% of games)
George Springer (Blue Jays): +500 to hit a HR | 2025 Stats: 5 HR in 42 games (has homered in 11.9% of games)
Gavin Sheets (Padres): +600 to hit a HR | 2025 Stats: 6 HR in 42 games (has homered in 14.3% of games)
Addison Barger (Blue Jays): +630 to hit a HR | 2025 Stats: 2 HR in 26 games (has homered in 7.7% of games)
Bo Bichette (Blue Jays): +630 to hit a HR | 2025 Stats: 4 HR in 47 games (has homered in 8.5% of games)
Jake Cronenworth (Padres): +630 to hit a HR | 2025 Stats: 3 HR in 22 games (has homered in 13.6% of games)
Jason Heyward (Padres): +750 to hit a HR | 2025 Stats: 2 HR in 29 games (has homered in 6.9% of games)
Alejandro Kirk (Blue Jays): +800 to hit a HR | 2025 Stats: 3 HR in 37 games (has homered in 8.1% of games)
Xander Bogaerts (Padres): +800 to hit a HR | 2025 Stats: 3 HR in 46 games (has homered in 6.5% of games)
Elias Diaz (Padres): +830 to hit a HR | 2025 Stats: 3 HR in 33 games (has homered in 9.1% of games)
Ernie Clement (Blue Jays): +830 to hit a HR | 2025 Stats: 1 HR in 40 games (has homered in 2.5% of games)
Nathan Lukes (Blue Jays): +900 to hit a HR | 2025 Stats: 3 HR in 30 games (has homered in 10% of games)
Luis Arraez (Padres): +1300 to hit a HR | 2025 Stats: 3 HR in 40 games (has homered in 7.5% of games)

New York Mets at Boston Red Sox

Rafael Devers (Red Sox): +450 to hit a HR | 2025 Stats: 10 HR in 50 games (has homered in 20% of games)
Francisco Lindor (Mets): +470 to hit a HR | 2025 Stats: 9 HR in 48 games (has homered in 16.7% of games)
Pete Alonso (Mets): +480 to hit a HR | 2025 Stats: 9 HR in 49 games (has homered in 18.4% of games)
Juan Soto (Mets): +520 to hit a HR | 2025 Stats: 8 HR in 48 games (has homered in 12.5% of games)
Wilyer Abreu (Red Sox): +540 to hit a HR | 2025 Stats: 11 HR in 47 games (has homered in 19.1% of games)
Alex Bregman (Red Sox): +560 to hit a HR | 2025 Stats: 11 HR in 49 games (has homered in 20.4% of games)
Mark Vientos (Mets): +800 to hit a HR | 2025 Stats: 5 HR in 45 games (has homered in 11.1% of games)
Jarren Duran (Red Sox): +830 to hit a HR | 2025 Stats: 3 HR in 49 games (has homered in 6.1% of games)
Abraham Toro (Red Sox): +870 to hit a HR | 2025 Stats: 1 HR in 8 games (has homered in 12.5% of games)
Brandon Nimmo (Mets): +870 to hit a HR | 2025 Stats: 8 HR in 47 games (has homered in 14.9% of games)
Trevor Story (Red Sox): +900 to hit a HR | 2025 Stats: 6 HR in 46 games (has homered in 10.9% of games)
Kristian Campbell (Red Sox): +900 to hit a HR | 2025 Stats: 5 HR in 41 games (has homered in 12.2% of games)
Tyrone Taylor (Mets): +1060 to hit a HR | 2025 Stats: 1 HR in 40 games (has homered in 2.5% of games)
Ceddanne Rafaela (Red Sox): +1060 to hit a HR | 2025 Stats: 2 HR in 43 games (has homered in 4.7% of games)
Carlos Narvaez (Red Sox): +1060 to hit a HR | 2025 Stats: 5 HR in 35 games (has homered in 14.3% of games)
Luis Torrens (Mets): +1060 to hit a HR | 2025 Stats: 1 HR in 28 games (has homered in 3.6% of games)
Starling Marte (Mets): +1300 to hit a HR | 2025 Stats: 2 HR in 29 games (has homered in 6.9% of games)
Luisangel Acuna (Mets): +1500 to hit a HR | 2025 Stats: 0 HR in 35 games
Nick Sogard (Red Sox): +10000 to hit a HR | 2025 Stats: 0 HR in 8 games

Kansas City Royals at San Francisco Giants

Bobby Witt Jr. (Royals): +500 to hit a HR | 2025 Stats: 5 HR in 49 games (has homered in 10.2% of games)
Mike Yastrzemski (Giants): +560 to hit a HR | 2025 Stats: 5 HR in 43 games (has homered in 11.6% of games)
Willy Adames (Giants): +630 to hit a HR | 2025 Stats: 5 HR in 48 games (has homered in 8.3% of games)
Heliot Ramos (Giants): +630 to hit a HR | 2025 Stats: 8 HR in 47 games (has homered in 17% of games)
Vinnie Pasquantino (Royals): +630 to hit a HR | 2025 Stats: 8 HR in 48 games (has homered in 16.7% of games)
Salvador Pérez (Royals): +680 to hit a HR | 2025 Stats: 2 HR in 46 games (has homered in 4.3% of games)
Casey Schmitt (Giants): +700 to hit a HR | 2025 Stats: 0 HR in 9 games
Wilmer Flores (Giants): +800 to hit a HR | 2025 Stats: 10 HR in 47 games (has homered in 17% of games)
Jonathan India (Royals): +870 to hit a HR | 2025 Stats: 1 HR in 44 games (has homered in 2.3% of games)
Jung Hoo Lee (Giants): +900 to hit a HR | 2025 Stats: 6 HR in 47 games (has homered in 10.6% of games)
Tyler Fitzgerald (Giants): +900 to hit a HR | 2025 Stats: 2 HR in 28 games (has homered in 7.1% of games)
LaMonte Wade (Giants): +900 to hit a HR | 2025 Stats: 1 HR in 41 games (has homered in 2.4% of games)
Michael Massey (Royals): +1000 to hit a HR | 2025 Stats: 2 HR in 43 games (has homered in 4.7% of games)
Maikel Garcia (Royals): +1100 to hit a HR | 2025 Stats: 5 HR in 47 games (has homered in 8.5% of games)
Patrick Bailey (Giants): +1100 to hit a HR | 2025 Stats: 0 HR in 39 games
Drew Waters (Royals): +1200 to hit a HR | 2025 Stats: 1 HR in 33 games (has homered in 3% of games)
Cavan Biggio (Royals): +1400 to hit a HR | 2025 Stats: 1 HR in 26 games (has homered in 3.8% of games)
Kyle Isbel (Royals): +1500 to hit a HR | 2025 Stats: 3 HR in 38 games (has homered in 7.9% of games)
Matt Chapman (Giants): +10000 to hit a HR | 2025 Stats: 8 HR in 48 games (has homered in 16.7% of games)

Atlanta Braves at Washington Nationals

Matt Olson (Braves): +430 to hit a HR | 2025 Stats: 10 HR in 48 games (has homered in 20.8% of games)
Marcell Ozuna (Braves): +440 to hit a HR | 2025 Stats: 8 HR in 45 games (has homered in 17.8% of games)
Austin Riley (Braves): +440 to hit a HR | 2025 Stats: 8 HR in 48 games (has homered in 12.5% of games)
James Wood (Nationals): +520 to hit a HR | 2025 Stats: 12 HR in 49 games (has homered in 22.4% of games)
C.J. Abrams (Nationals): +520 to hit a HR | 2025 Stats: 8 HR in 36 games (has homered in 19.4% of games)
Drake Baldwin (Braves): +560 to hit a HR | 2025 Stats: 5 HR in 29 games (has homered in 17.2% of games)
Luis Garcia (Nationals): +600 to hit a HR | 2025 Stats: 4 HR in 42 games (has homered in 9.5% of games)
Josh Bell (Nationals): +630 to hit a HR | 2025 Stats: 6 HR in 41 games (has homered in 14.6% of games)
Alex Verdugo (Braves): +750 to hit a HR | 2025 Stats: 0 HR in 27 games
Michael Harris II (Braves): +750 to hit a HR | 2025 Stats: 3 HR in 48 games (has homered in 6.3% of games)
Amed Rosario (Nationals): +750 to hit a HR | 2025 Stats: 2 HR in 24 games (has homered in 8% of games)
Nathaniel Lowe (Nationals): +800 to hit a HR | 2025 Stats: 8 HR in 49 games (has homered in 16.3% of games)
Ozzie Albies (Braves): +830 to hit a HR | 2025 Stats: 5 HR in 48 games (has homered in 10.4% of games)
Keibert Ruiz (Nationals): +870 to hit a HR | 2025 Stats: 2 HR in 43 games (has homered in 4.7% of games)
Eli White (Braves): +1000 to hit a HR | 2025 Stats: 2 HR in 33 games (has homered in 6.1% of games)
Jose Tena (Nationals): +1000 to hit a HR | 2025 Stats: 0 HR in 29 games
Jacob Young (Nationals): +1500 to hit a HR | 2025 Stats: 0 HR in 36 games
Nick Allen (Braves): +1500 to hit a HR | 2025 Stats: 0 HR in 39 games
Sean Murphy (Braves): +10000 to hit a HR | 2025 Stats: 8 HR in 30 games (has homered in 23.3% of games)
Dylan Crews (Nationals): +10000 to hit a HR | 2025 Stats: 7 HR in 45 games (has homered in 13.3% of games)

Cleveland Guardians at Minnesota Twins

Kyle Manzardo (Guardians): +420 to hit a HR | 2025 Stats: 10 HR in 41 games (has homered in 24.4% of games)
José Ramírez (Guardians): +420 to hit a HR | 2025 Stats: 9 HR in 44 games (has homered in 15.9% of games)
Ryan Jeffers (Twins): +460 to hit a HR | 2025 Stats: 3 HR in 35 games (has homered in 8.6% of games)
Bo Naylor (Guardians): +460 to hit a HR | 2025 Stats: 6 HR in 35 games (has homered in 17.1% of games)
Carlos Santana (Guardians): +470 to hit a HR | 2025 Stats: 4 HR in 44 games (has homered in 9.1% of games)
Royce Lewis (Twins): +540 to hit a HR | 2025 Stats: 1 HR in 12 games (has homered in 8.3% of games)
Harrison Bader (Twins): +560 to hit a HR | 2025 Stats: 4 HR in 38 games (has homered in 10.5% of games)
Carson McCusker (Twins): +560 to hit a HR | 2025 Stats: 0 HR in 1 game
Ty France (Twins): +600 to hit a HR | 2025 Stats: 3 HR in 46 games (has homered in 6.5% of games)
Brooks Lee (Twins): +630 to hit a HR | 2025 Stats: 4 HR in 31 games (has homered in 12.9% of games)
Trevor Larnach (Twins): +750 to hit a HR | 2025 Stats: 7 HR in 46 games (has homered in 15.2% of games)
Angel Martinez (Guardians): +830 to hit a HR | 2025 Stats: 1 HR in 32 games (has homered in 3.1% of games)
Gabriel Arias (Guardians): +870 to hit a HR | 2025 Stats: 4 HR in 42 games (has homered in 9.5% of games)
Nolan Jones (Guardians): +900 to hit a HR | 2025 Stats: 2 HR in 40 games (has homered in 5% of games)
Jonah Bride (Twins): +1000 to hit a HR | 2025 Stats: 0 HR in 26 games
Willi Castro (Twins): +1000 to hit a HR | 2025 Stats: 2 HR in 28 games (has homered in 7.1% of games)
Steven Kwan (Guardians): +1100 to hit a HR | 2025 Stats: 4 HR in 46 games (has homered in 8.7% of games)
Will Brennan (Guardians): +1300 to hit a HR | 2025 Stats: 0 HR in 5 games
Daniel Schneemann (Guardians): +10000 to hit a HR | 2025 Stats: 6 HR in 34 games (has homered in 14.7% of games)
Kody Clemens (Twins): +10000 to hit a HR | 2025 Stats: 3 HR in 21 games (has homered in 14.3% of games)
DaShawn Keirsey Jr. (Twins): +10000 to hit a HR | 2025 Stats: 1 HR in 17 games (has homered in 5.9% of games)
Byron Buxton (Twins): +10000 to hit a HR | 2025 Stats: 10 HR in 41 games (has homered in 24.4% of games)

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