Astros vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Odds updated as of 2:11 a.m.

The MLB's Wednesday schedule includes the Houston Astros taking on the Tampa Bay Rays.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Rays Game Info

• Houston Astros (25-23) vs. Tampa Bay Rays (22-26)
• Date: Wednesday, May 21, 2025
• Time: 1:10 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and SCHN

Astros vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-142) | TB: (+120)
• Spread: HOU: -1.5 (+112) | TB: +1.5 (-134)
• Total: 9 -- Over: (-105) | Under: (-115)

Astros vs Rays Probable Starting Pitchers

Probable Pitchers: Hunter Brown (Astros) - 6-2, 1.43 ERA vs Taj Bradley (Rays) - 3-3, 4.80 ERA

The probable starters are Hunter Brown (6-2) for the Astros and Taj Bradley (3-3) for the Rays. Brown's team is 7-2-0 against the spread in his starts this season. Brown's team has won 71.4% of his starts when they are favored on the moneyline (5-2). The Rays are 4-5-0 ATS in Bradley's nine starts that had a set spread. The Rays have a 2-1 record in Bradley's three starts this season when they were the underdog on the moneyline.

Astros vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.9%)

Astros vs Rays Moneyline

• The moneyline numbers for Astros vs. Rays reveal Houston as the favorite (-142) and Tampa Bay as the underdog (+120) despite being the home team.

Astros vs Rays Spread

• The Rays are +1.5 on the spread (-134 to cover), and Houston is +112 to cover the runline.

Astros vs Rays Over/Under

• Astros versus Rays on May 21 has an over/under of 9 runs, with the odds on the over -105 and the under set at -115.

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Astros vs Rays Betting Trends

• The Astros have won in 18, or 56.2%, of the 32 contests they have been named as odds-on favorites in this year.
• Houston has a record of 7-6 when favored by -142 or more this year.
• The Astros and their opponents have hit the over in 19 of their 48 games with a total set by oddsmakers this season.
• The Astros have posted a record of 26-22-0 against the spread this season.
• The Rays have a 10-11 record in games they were listed as the moneyline underdog (winning 47.6% of those games).
• In games it has played as a moneyline underdog with odds of +120 or longer, Tampa Bay has a record of 6-7 (46.2%).
• In the 47 games bookmakers have set an over/under for the Rays, they have combined with opponents to go over the total 18 times (18-27-2).
• The Rays have covered 42.6% of their games this season, going 20-27-0 against the spread.

Astros Player Leaders

• Isaac Paredes leads Houston in OBP (.376) and total hits (46) this season. He's batting .264 batting average while slugging .448.
• He is 67th in batting average, 27th in on-base percentage, and 59th in slugging among qualified hitters in baseball.
• Paredes has picked up at least one hit in five games in a row. During his last five outings he is hitting .300 with two home runs, two walks and six RBIs.
• Jeremy Pena leads Houston in slugging percentage (.445) thanks to 14 extra-base hits. He's batting .302 with an on-base percentage of .358.
• Among qualifying batters, he is 18th in batting average, 51st in on-base percentage and 62nd in slugging percentage.
• Jake Meyers is batting .307 with a .436 slugging percentage and 16 RBI this year.
• Meyers enters this game with five games in a row with at least one hit. During his last five outings he is batting .412 with a double, a home run, three walks and two RBIs.
• Jose Altuve has been key for Houston with 44 hits, an OBP of .294 plus a slugging percentage of .341.

Rays Player Leaders

• Yandy Diaz has racked up a team-high .400 slugging percentage. He's batting .250 with an on-base percentage of .301.
• Including all qualifying hitters, he ranks 90th in batting average, while his on-base percentage ranks 118th and he is 97th in slugging.
• Diaz hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .350 with a double, a walk and four RBIs.
• Jonathan Aranda paces his team with 44 hits and a .396 on-base percentage. He has a batting average of .310 while slugging .500.
• Including all qualified hitters, his batting average places him 10th, his on-base percentage ranks 10th, and he is 27th in slugging.
• Junior Caminero is batting .230 with six doubles, eight home runs and eight walks.
• Brandon Lowe is batting .223 with three doubles, seven home runs and 13 walks.

Astros vs Rays Head to Head

• 5/20/2025: 3-2 TB (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/19/2025: 4-3 HOU (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/14/2024: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/13/2024: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/12/2024: 6-1 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/4/2024: 1-0 TB (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 8/3/2024: 6-1 TB (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/2/2024: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/30/2023: 8-2 TB (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/29/2023: 17-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)

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