Louisville vs Florida State Prediction, Odds, Picks, Best Bets for Week 6 2026

College football's Friday schedule includes the Louisville Cardinals taking on the Florida State Seminoles.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding today's NCAA football betting odds.

Louisville vs Florida State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-188) | Florida State: (+155)
• Spread: Louisville: -3.5 (-115) | Florida State: +3.5 (-105)
• Total: 60.5 -- Over: (-110) | Under: (-112)

Louisville vs Florida State Betting Trends

• Louisville has beaten the spread three times in five games.
• Louisville has won once ATS (1-2) as a 3.5-point or higher favorite this season.
• This year, four of Louisville's five games have gone over the point total.
• Against the spread, Florida State is 3-2-0 this year.
• Florida State has yet to lose ATS (2-0) as a 3.5-point underdog or greater this year.
• Florida State has had one game (of five) hit the over this year.

Louisville vs Florida State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.7%)

Louisville vs Florida State Point Spread

Florida State is a 3.5-point underdog against Louisville. Florida State is -105 to cover the spread, and Louisville is -115.

Louisville vs Florida State Over/Under

The Louisville-Florida State matchup on Oct. 9 has been given an over/under of 60.5 points. The over is -110 and the under is -112.

Louisville vs Florida State Moneyline

Looking at the moneyline for Louisville-Florida State, Louisville is the favorite at -188, and Florida State is +155.

Louisville vs. Florida State Points Insights

Louisville vs. Florida State Game Info

• Game day: Friday, October 9, 2026
• Game time: 7 p.m. ET
• TV channel: ESPN
• Location: Louisville, Kentucky
• Stadium: L&N Federal Credit Union Stadium

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