Iowa State vs Iowa Prediction, Odds, Picks, Best Bets for Week 2 2025

On Saturday in college football, the Iowa State Cyclones are up against the Iowa Hawkeyes.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the vital information about today's NCAA football betting odds.

Iowa State vs Iowa Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Iowa State: (-156) | Iowa: (+130)
• Spread: Iowa State: -3.5 (-102) | Iowa: +3.5 (-120)
• Total: 41.5 -- Over: (-110) | Under: (-110)

Iowa State vs Iowa Betting Trends

• Iowa State has two wins against the spread this season.
• Iowa State has yet to lose ATS (1-0) as a 3.5-point favorite or greater this season.
• Iowa State has had one game (of two) hit the over this season.
• Iowa is winless against the spread this season.
• Iowa and its opponent have yet to hit the over this year.

Iowa State vs Iowa Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hawkeyes win (51.4%)

Iowa State vs Iowa Point Spread

Iowa is listed as an underdog by 3.5 points (-120 odds), and Iowa State, the favorite, is -102 to cover.

Iowa State vs Iowa Over/Under

Iowa State versus Iowa, on Sept. 6, has an over/under of 41.5, with the over being -110 and the under -110.

Iowa State vs Iowa Moneyline

Iowa State is the favorite, -156 on the moneyline, while Iowa is a +130 underdog.

Iowa State vs. Iowa Points Insights

• The Cyclones' average implied point total last season was 6.0 more points than their implied total in Saturday's game (29.0 implied points on average compared to 23 implied points in this game).
• The Hawkeyes' average implied point total last season (23.9 points) is 4.9 points higher than their implied total in this matchup (19 points).

Iowa State vs. Iowa Game Info

• Game day: Saturday, September 6, 2025
• Game time: 12 p.m. ET
• TV channel: FOX
• Location: Ames, Iowa
• Stadium: Jack Trice Stadium

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Check out even more in-depth Iowa State vs. Iowa analysis on FanDuel Research.