Illinois vs Purdue Prediction, Odds, Picks, Best Bets for Week 6 2025

NCAA football action on Saturday includes the Illinois Fighting Illini taking on the Purdue Boilermakers.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Illinois vs Purdue Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Illinois: (-375) | Purdue: (+290)
• Spread: Illinois: -9.5 (-118) | Purdue: +9.5 (-104)
• Total: 57.5 -- Over: (-104) | Under: (-118)

Illinois vs Purdue Betting Trends

• Illinois has covered the spread four times in five games.
• Illinois has yet to lose ATS (2-0) as a 9.5-point favorite or greater this season.
• This season, three of Illinois' five games have hit the over.
• Purdue owns two wins against the spread this season.
• Purdue has one win ATS (1-1) as a 9.5-point underdog or more this season.
• Purdue has had one game (of four) go over the total this year.

Illinois vs Purdue Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Fighting Illini win (78.9%)

Illinois vs Purdue Point Spread

Illinois is favored by 9.5 points (-118 to cover) in this matchup. Purdue, the underdog, is -104.

Illinois vs Purdue Over/Under

The Illinois-Purdue game on Oct. 4 has been given an over/under of 57.5 points. The over is -104 and the under is -118.

Illinois vs Purdue Moneyline

Looking at the moneyline for Illinois-Purdue, Illinois is the favorite at -375, and Purdue is +290.

Illinois vs. Purdue Points Insights

Illinois vs. Purdue Game Info

• Game day: Saturday, October 4, 2025
• Game time: 12 p.m. ET
• TV channel: BTN
• Location: West Lafayette, Indiana
• Stadium: Ross-Ade Stadium

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Check out even more in-depth Illinois vs. Purdue analysis on FanDuel Research.