Houston vs Iowa State Basketball Prediction, Odds, Picks, Best Bets for February 22

The Houston Cougars (22-4, 14-1 Big 12) will attempt to continue a five-game winning streak when they host the Iowa State Cyclones (21-5, 11-4 Big 12) on February 22, 2025. The Cyclones have won four games in a row.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Houston vs. Iowa State Game Info and Odds

• Game day: Saturday, February 22, 2025
• Game time: 2:00 PM ET
• TV channel: ESPN
• Location: Houston, Texas
• Arena: Fertitta Center

Houston vs. Iowa State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Houston win (74.9%)

Before placing a wager on Saturday's Houston-Iowa State spread (Houston -12.5) or total (131.5 points), read the betting trends and insights below.

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Houston vs. Iowa State: ATS Betting Stats and Trends

• Houston has compiled a 16-10-0 ATS record so far this year.
• Iowa State has covered 15 times in 26 chances against the spread this year.
• The Cougars own a worse record against the spread at home (10-4-0) than they do on the road (6-2-0).
• The Cyclones' winning percentage against the spread at home is .533 (8-7-0). Away, it is .625 (5-3-0).
• Against the spread, in conference action, Houston is 11-4-0 this season.
• Iowa State's Big 12 record against the spread is 10-6-0.

Houston vs. Iowa State: Moneyline Betting Stats

• Houston has been victorious in 21, or 84%, of the 25 contests it has been chosen as moneyline favorites in this season.
• The Cougars have a mark of 13-1 in contests where oddsmakers favor them by -1000 or better on the moneyline.
• Iowa State has compiled a 1-3 record in games it was the underdog on the moneyline (winning 25% of those games).
• The Cyclones have not yet played as a moneyline underdog of +640 or longer.
• The moneyline set for this matchup implies Houston has a 90.9% chance of coming away with a victory in the contest.

Houston vs. Iowa State Head-to-Head Comparison

• Houston is outscoring opponents by 17.8 points per game with a +462 scoring differential overall. It puts up 75.4 points per game (139th in college basketball) and allows 57.6 per outing (first in college basketball).
• LJ Cryer paces Houston, scoring 14.5 points per game (316th in the country).
• Iowa State outscores opponents by 14.4 points per game (posting 81.3 points per game, 30th in college basketball, and giving up 66.9 per contest, 50th in college basketball) and has a +375 scoring differential.
• Curtis Jones is ranked 105th in the country with a team-high 17.2 points per game.
• The 33.4 rebounds per game the Cougars average rank 101st in college basketball, and are 7.6 more than the 25.8 their opponents pull down per outing.
• J'wan Roberts' 6.4 rebounds per game lead the Cougars and rank 246th in college basketball action.
• The Cyclones are 77th in the country at 34 rebounds per game. That's 6.1 more than the 27.9 their opponents average.
• Joshua Jefferson averages 7.9 rebounds per game (68th in college basketball) to lead the Cyclones.
• Houston's 103.6 points per 100 possessions on offense rank 29th in college basketball, and the 79.2 points it allows per 100 possessions rank first in college basketball.
• The Cyclones rank 37th in college basketball averaging 103.2 points per 100 possessions on offense, and defensively are 18th, allowing 84.9 points per 100 possessions.

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