Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 1:12 a.m.

The MLB schedule on Tuesday includes the Cleveland Guardians facing the Chicago White Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Guardians vs White Sox Game Info

• Cleveland Guardians (76-75) vs. Chicago White Sox (77-73)
• Date: Tuesday, September 15, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | CHW: (+108)
• Spread: CLE: -1.5 (+168) | CHW: +1.5 (-205)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Foster Griffin (Guardians) - 15-5, 3.65 ERA vs Davis Martin (White Sox) - 9-7, 4.05 ERA

The probable pitchers are Foster Griffin (15-5) for the Guardians and Davis Martin (9-7) for the White Sox. Griffin's team is 17-10-0 against the spread in his starts this season. Griffin's team has a record of 7-3 this season when he starts and they are the favorite on the moneyline. The White Sox are 13-13-0 ATS in Martin's 26 starts with a set spread. The White Sox have a 10-6 record in Martin's 16 starts this season when they were the underdog on the moneyline.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.6%)

Guardians vs White Sox Moneyline

• The Guardians vs White Sox moneyline has Cleveland as a -126 favorite, while Chicago is a +108 underdog on the road.

Guardians vs White Sox Spread

• The Guardians are hosting the White Sox and are favored by 1.5 runs on the spread. The Guardians are +168 to cover the runline, with the White Sox being -205.

Guardians vs White Sox Over/Under

• Guardians versus White Sox, on Sept. 15, has an over/under of 8.5, with the over being -102 and the under -120.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have come away with 43 wins in the 85 contests they have been listed as the favorites in this season.
• This year Cleveland has won 27 of 56 games when listed as at least -126 on the moneyline.
• Contests with the Guardians have gone over the total set by oddsmakers in 70 of 143 chances this season.
• The Guardians have posted a record of 67-76-0 against the spread this season.
• The White Sox have gone 50-53 in games they were listed as the moneyline underdog (winning 48.5% of those games).
• When it has played as a moneyline underdog with odds of +108 or longer, Chicago has a 40-39 record (winning 50.6% of its games).
• The White Sox have played in 147 games with a set over/under, and have combined with their opponents to go over the total 81 times (81-65-1).
• The White Sox have collected an 82-65-0 record ATS this season (covering 55.8% of the time).

Guardians Player Leaders

• Chase DeLauter has 134 hits, which is best among Cleveland hitters this season, while batting .289 with 45 extra-base hits. He has an on-base percentage of .362 and a slugging percentage of .453.
• He is 13th in batting average, 26th in on-base percentage, and 44th in slugging among qualifying batters in MLB.
• Steven Kwan has a slash line of .278/.375/.346 this season and a team-best OPS of .721.
• Among all qualified, he ranks 28th in batting average, 10th in on-base percentage and 129th in slugging percentage.
• Kwan enters this game looking to extend his eight-game hit streak. During his last 10 outings he is hitting .350 with four doubles, a home run, five walks and three RBIs.
• Jose Ramirez is batting .230 with a .362 slugging percentage and 48 RBI this year.
• Brayan Rocchio has 13 home runs, 65 RBI and a batting average of .247 this season.
• Rocchio has hit safely in two straight games. During his last five outings he is hitting .176 with a double, a walk and three RBIs.

White Sox Player Leaders

• Miguel Vargas paces the White Sox with 137 hits. He's batting .249 and slugging .475 with an on-base percentage of .357.
• He is 79th in batting average, 36th in on-base percentage and 27th in slugging percentage among all qualifying hitters in MLB.
• Vargas brings a four-game hitting streak into this game. During his last five outings he is batting .238 with a home run, two walks and two RBIs.
• Sam Antonacci has a .366 OBP to lead his team. He has a batting average of .269 while slugging .392.
• Including all qualified hitters, he is 41st in batting average, 21st in on-base percentage and 98th in slugging percentage.
• Chase Meidroth has a .397 slugging percentage, which leads the White Sox.
• Tristan Peters has 31 doubles, four triples, 12 home runs and 35 walks while batting .277.

Guardians vs White Sox Head to Head

• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/23/2026: 2-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/22/2026: 6-5 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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