Brewers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 1:12 a.m.

The Tuesday schedule in MLB includes a matchup between the Milwaukee Brewers and the Pittsburgh Pirates.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Brewers vs Pirates Game Info

• Milwaukee Brewers (93-57) vs. Pittsburgh Pirates (75-75)
• Date: Tuesday, September 15, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and Brewers.TV

Brewers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIL: (-250) | PIT: (+205)
• Spread: MIL: -1.5 (-137) | PIT: +1.5 (+114)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Brewers vs Pirates Probable Starting Pitchers

Probable Pitchers: Jacob Misiorowski (Brewers) - 14-5, 1.95 ERA vs Lake Bachar (Pirates) - 1-3, 3.52 ERA

The probable starters are Jacob Misiorowski (14-5) for the Brewers and Lake Bachar (1-3) for the Pirates. Misiorowski's team is 16-11-0 against the spread this season in his starts. Misiorowski's team has a record of 18-6 this season when he starts and they are the favorite on the moneyline. The Pirates are 7-2-0 ATS in Bachar's nine starts that had a set spread. The Pirates are 5-2 in Bachar's seven starts this season that they were the moneyline underdog.

Brewers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Brewers win (52.9%)

Brewers vs Pirates Moneyline

• Pittsburgh is a +205 underdog on the moneyline, while Milwaukee is a -250 favorite on the road.

Brewers vs Pirates Spread

• The Pirates are at +1.5 on the runline against the Brewers. The Pirates are +114 to cover the spread, and the Brewers are -137.

Brewers vs Pirates Over/Under

• A combined run total of 7.5 has been set for Brewers-Pirates on Sept. 15, with the over at -114 and the under at -106.

Bet on Milwaukee Brewers vs. Pittsburgh Pirates on FanDuel today!

Brewers vs Pirates Betting Trends

• The Brewers have been chosen as favorites in 116 games this year and have walked away with the win 74 times (63.8%) in those games.
• Milwaukee has a record of 5-1 when favored by -250 or more this year.
• The Brewers and their opponents have hit the over in 65 of their 149 games with a total set by oddsmakers this season.
• The Brewers have an against the spread mark of 78-71-0 in 149 games with a line this season.
• The Pirates have gone 31-39 in games they were listed as the moneyline underdog (winning 44.3% of those games).
• Pittsburgh has played as a moneyline underdog of +205 or longer in only two games this season, which it lost both.
• The Pirates have combined with opponents to hit the over on the total 77 times this season for a 77-67-4 record against the over/under.
• The Pirates have collected a 72-76-0 record ATS this season (covering 48.6% of the time).

Brewers Player Leaders

• Brice Turang leads Milwaukee with a slugging percentage of .445, fueled by 55 extra-base hits. He has a .267 batting average and an on-base percentage of .365.
• He is 52nd in batting average, 23rd in on-base percentage, and 51st in slugging among all qualifying batters in baseball.
• Turang hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .588 with two doubles, two home runs, five walks and seven RBIs.
• William Contreras leads Milwaukee in slugging percentage (.420) thanks to 43 extra-base hits. He's batting .273 with an on-base percentage of .343.
• His batting average ranks 34th among qualified players, his on-base percentage 49th, and his slugging percentage 74th.
• Contreras heads into this game looking to extend his four-game hit streak. During his last five outings he is batting .316 with three home runs, four walks and 12 RBIs.
• Jake Bauers leads Milwaukee with 119 hits and an OBP of .394 this season.
• Bauers enters this matchup with three games in a row with at least one hit. In his last five games he is hitting .250 with two home runs, two walks and five RBIs.
• Jackson Chourio has been key for Milwaukee with 140 hits, an OBP of .349 plus a slugging percentage of .493.

Pirates Player Leaders

• Bryan Reynolds has a team-high .370 on-base percentage. He's batting .266 and slugging .429.
• He is 56th in batting average, 16th in on-base percentage and 65th in slugging percentage among all qualifying hitters in the big leagues.
• Reynolds takes a three-game hitting streak into this game. In his last five games he is hitting .200 with a home run, two walks and two RBIs.
• Brandon Lowe paces his team with 140 hits. He has a batting average of .258 while slugging .474 with an on-base percentage of .327.
• He is 66th in batting average, 74th in on-base percentage and 28th in slugging percentage in the majors.
• Nick Gonzales has put up a team-high .393 slugging percentage.
• Ryan O'Hearn is batting .266 with 15 doubles, 18 home runs and 31 walks.

Brewers vs Pirates Head to Head

• 8/6/2026: 5-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +110)
• 8/5/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/4/2026: 4-2 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +132)
• 8/3/2026: 4-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +136)
• 7/12/2026: 14-5 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2026: 3-2 PIT (Favorite: Brewers, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/11/2026: 7-6 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2026: 5-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/25/2026: 6-3 PIT (Favorite: Brewers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/24/2026: 6-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: +100)

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