Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 11

Odds updated as of 4:12 a.m.

In MLB action on Thursday, the Cleveland Guardians play the Kansas City Royals.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Royals Game Info

• Cleveland Guardians (74-71) vs. Kansas City Royals (74-72)
• Date: Thursday, September 11, 2025
• Time: 7:15 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: FOX

Guardians vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-134) | KC: (+114)
• Spread: CLE: -1.5 (+146) | KC: +1.5 (-178)
• Total: 8 -- Over: (-106) | Under: (-114)

Guardians vs Royals Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 10-5, 3.17 ERA vs Stephen Kolek (Royals) - 5-5, 3.88 ERA

The Guardians will give the ball to Gavin Williams (10-5, 3.17 ERA), who is eyeing win No. 11 on the season, and the Royals will turn to Stephen Kolek (5-5, 3.88 ERA). When Williams starts, his team is 13-15-0 against the spread this season. Williams' team has a record of 6-4 this season when he starts and they are the favorite on the moneyline. When Kolek starts, the Royals have gone 11-5-0 against the spread. The Royals have a 4-5 record in Kolek's nine starts this season when they were the underdog on the moneyline.

Guardians vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.1%)

Guardians vs Royals Moneyline

• Kansas City is the underdog, +114 on the moneyline, while Cleveland is a -134 favorite at home.

Guardians vs Royals Spread

• The Guardians are favored by 1.5 runs at home against the Royals. The Guardians are +146 to cover the spread, while the Royals are -178.

Guardians vs Royals Over/Under

• A combined run total of 8 has been set for Guardians-Royals on Sept. 11, with the over at -106 and the under at -114.

Bet on Cleveland Guardians vs. Kansas City Royals on FanDuel today!

Guardians vs Royals Betting Trends

• The Guardians have come away with 36 wins in the 58 contests they have been listed as the favorites in this season.
• This season Cleveland has come away with a win 16 times in 23 chances when named as a favorite of at least -134 on the moneyline.
• Contests with the Guardians have gone over the total set by oddsmakers in 63 of 142 chances this season.
• In 142 games with a line this season, the Guardians have a mark of 76-66-0 against the spread.
• The Royals are 38-44 in games they were the underdog on the moneyline (winning 46.3% of those games).
• Kansas City has a record of 19-22 when it has played as a moneyline underdog with odds of +114 or longer (46.3%).
• In the 144 games bookmakers have set an over/under for the Royals, they have combined with opponents to go over the total 60 times (60-82-2).
• The Royals have gone 70-74-0 ATS this season.

Guardians Player Leaders

• Jose Ramirez has 152 hits and an OBP of .361, both of which lead Cleveland hitters this season. He has a .287 batting average and a slugging percentage of .511.
• Among all qualified hitters in the majors, he is 17th in batting average, 20th in on-base percentage, and 15th in slugging.
• Ramirez has picked up at least one hit in seven games in a row. In his last 10 games he is hitting .342 with four doubles, a triple, two home runs, three walks and eight RBIs.
• Steven Kwan has an OPS of .714, fueled by an OBP of .335 and a team-best slugging percentage of .379 this season. He's batting .276.
• His batting average is 31st among qualified players, his on-base percentage 60th, and his slugging percentage 126th.
• Kyle Manzardo is batting .240 with a .477 slugging percentage and 67 RBI this year.
• Manzardo heads into this game with three games in a row with at least one hit. In his last five games he is hitting .400 with a double, two home runs, four walks and five RBIs.
• Angel Martinez has been key for Cleveland with 92 hits, an OBP of .264 plus a slugging percentage of .355.

Royals Player Leaders

• Bobby Witt Jr. has accumulated 163 hits with a .501 slugging percentage, both team-best statistics for the Royals. He's batting .295 and with an on-base percentage of .352.
• Including all qualified players, he ranks eighth in batting average, while his on-base percentage ranks 34th and he is 20th in slugging.
• Maikel Garcia leads his team with a .355 on-base percentage. He has a batting average of .292 while slugging .467.
• Including all qualified hitters, he ranks 11th in batting average, 30th in on-base percentage and 42nd in slugging percentage.
• Vinnie Pasquantino is hitting .262 with 24 doubles, a triple, 29 home runs and 44 walks.
• Salvador Perez is batting .235 with 34 doubles, 25 home runs and 23 walks.

Guardians vs Royals Head to Head

• 9/10/2025: 4-3 KC (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/26/2025: 6-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/26/2025: 5-3 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/12/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/11/2025: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2025: 6-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)

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