Guardians vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 2:12 a.m.

The Wednesday slate in MLB includes a matchup between the Kansas City Royals and the Cleveland Guardians.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Royals vs Guardians Game Info

• Kansas City Royals (73-72) vs. Cleveland Guardians (74-70)
• Date: Wednesday, September 10, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSKC

Royals vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: KC: (-112) | CLE: (-104)
• Spread: KC: -1.5 (+152) | CLE: +1.5 (-184)
• Total: 8 -- Over: (-110) | Under: (-110)

Royals vs Guardians Probable Starting Pitchers

Probable Pitchers: Jonathan Bowlan (Royals) - 1-2, 3.57 ERA vs Logan Allen (Guardians) - 7-11, 4.46 ERA

The Royals will look to Jonathan Bowlan (1-2) against the Guardians and Logan Allen (7-11). Bowlan pitched in one game with a spread last season and his team covered. Bowlan did not appear in a game when his team was the moneyline favorite last season. The Guardians are 12-13-0 against the spread when Allen starts. The Guardians have been the underdog on the moneyline in 16 of Allen's starts this season, and they went 6-10 in those games.

Royals vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Royals win (54.2%)

Royals vs Guardians Moneyline

• The Royals vs Guardians moneyline has Kansas City as a -112 favorite, while Cleveland is a -104 underdog at home.

Royals vs Guardians Spread

• The Guardians are +1.5 on the run line against the Royals. The Guardians are -184 to cover, and the Royals are +152.

Royals vs Guardians Over/Under

• Royals versus Guardians, on Sept. 10, has an over/under of 8, with the over being -110 and the under -110.

Bet on Kansas City Royals vs. Cleveland Guardians on FanDuel today!

Royals vs Guardians Betting Trends

• The Royals have been victorious in 35, or 56.5%, of the 62 contests they have been chosen as favorites in this season.
• Kansas City has a record of 35-27 when favored by -112 or more this year.
• The Royals' games have gone over the total in 60 of their 143 opportunities.
• The Royals are 70-73-0 against the spread in their 143 games that had a posted line this season.
• The Guardians have won 43.9% of the games this season they were the moneyline underdog (36-46).
• Cleveland is 34-43 (winning 44.2% of its games) when playing as a moneyline underdog of -104 or longer.
• In the 141 games bookmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 63 times (63-72-6).
• The Guardians have collected a 75-66-0 record ATS this season (covering 53.2% of the time).

Royals Player Leaders

• Bobby Witt Jr. has 161 hits to go with a slugging percentage of .501, both of which are tops among Kansas City hitters this season. He has a .293 batting average and an on-base percentage of .351.
• Among qualified hitters in the majors, his batting average ranks 10th, his on-base percentage ranks 35th, and he is 20th in slugging.
• Maikel Garcia has 154 hits this season and a team-best OBP of .354. He's batting .290 and slugging .465.
• Among qualifiers, he ranks 13th in batting average, 32nd in on-base percentage and 43rd in slugging percentage.
• Vinnie Pasquantino has collected 143 base hits, an OBP of .321 and a slugging percentage of .465 this season.
• Salvador Perez has been key for Kansas City with 125 hits, an OBP of .278 plus a slugging percentage of .438.

Guardians Player Leaders

• Jose Ramirez has a team-high OBP (.360), and leads the Guardians in hits (151). He's batting .287 and slugging.
• Including all the qualifying hitters in the majors, his batting average ranks 17th, his on-base percentage is 21st, and he is 16th in slugging.
• Ramirez hopes to build on a six-game hitting streak in this matchup. During his last 10 games he is batting .308 with three doubles, a triple, two home runs, two walks and eight RBIs.
• Steven Kwan is slugging .379 to pace his team. He has a batting average of .275 with an on-base percentage of .335.
• Including all qualified hitters, he ranks 32nd in batting average, 60th in on-base percentage and 127th in slugging percentage.
• Kyle Manzardo is batting .239 with 15 doubles, two triples, 25 home runs and 45 walks.
• Angel Martinez has 21 doubles, a triple, 10 home runs and 17 walks while batting .227.

Royals vs Guardians Head to Head

• 9/9/2025: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/8/2025: 10-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/27/2025: 4-1 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/26/2025: 6-4 CLE (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/26/2025: 5-3 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/13/2025: 4-2 KC (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/12/2025: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/11/2025: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 3/30/2025: 6-2 CLE (Favorite: Royals, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 3/29/2025: 4-3 KC (Favorite: Royals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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