Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 4:11 a.m.

The Cleveland Guardians will face the Cincinnati Reds in MLB action on Saturday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Reds Game Info

• Cleveland Guardians (24-22) vs. Cincinnati Reds (24-21)
• Date: Saturday, May 16, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Reds.TV

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-168) | CIN: (+142)
• Spread: CLE: -1.5 (+118) | CIN: +1.5 (-142)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Joey Cantillo (Guardians) - 3-1, 2.98 ERA vs Chris Paddack (Reds) - 0-5, 7.63 ERA

The probable starters are Joey Cantillo (3-1) for the Guardians and Chris Paddack (0-5) for the Reds. Cantillo's team is 7-2-0 against the spread this season in his starts. Cantillo's team has been victorious in 75% of the games he's started as the moneyline favorite with a record of 3-1. The Reds are 1-5-0 against the spread when Paddack starts. The Reds were the moneyline underdog for four Paddack starts this season -- they lost each time.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (54.4%)

Guardians vs Reds Moneyline

• The Guardians vs Reds moneyline has Cleveland as a -168 favorite, while Cincinnati is a +142 underdog on the road.

Guardians vs Reds Spread

• The Reds are +1.5 on the run line against the Guardians. The Reds are -142 to cover, and the Guardians are +118.

Guardians vs Reds Over/Under

• An over/under of 8.5 has been set for Guardians-Reds on May 16, with the over being -104 and the under -118.

Bet on Cleveland Guardians vs. Cincinnati Reds on FanDuel today!

Guardians vs Reds Betting Trends

• The Guardians have come away with 12 wins in the 23 contests they have been listed as the favorites in this season.
• Cleveland has played as a favorite of -168 or more just one time this year and came away with a win in that game.
• The Guardians and their opponents have gone over the total this season in 23 of their 44 opportunities.
• The Guardians are 23-21-0 against the spread in their 44 games that had a posted line this season.
• The Reds have been the moneyline underdog 26 total times this season. They've gone 15-11 in those games.
• Cincinnati has played as a moneyline underdog of +142 or longer in just one game this season, which it lost.
• The Reds have combined with opponents to go over the total 27 times this season for a 27-15-1 record against the over/under.
• The Reds have put together a 26-17-0 record ATS this season (covering 60.5% of the time).

Guardians Player Leaders

• Jose Ramirez is batting .220 with nine doubles, six home runs and 32 walks. He has an on-base percentage of .347 while slugging .381.
• Among all qualifying batters in MLB, he ranks 130th in batting average, 65th in on-base percentage, and 105th in slugging.
• Chase DeLauter leads Cleveland in OBP (.371), slugging percentage (.490) and total hits (42) this season. He's batting .286.
• His batting average ranks 32nd among qualified players, his on-base percentage 34th, and his slugging percentage 34th.
• Brayan Rocchio is batting .269 with a .366 slugging percentage and 23 RBI this year.
• Angel Martinez has been key for Cleveland with 35 hits, an OBP of .303 plus a slugging percentage of .467.
• Martinez has safely hit in four straight games. During his last five outings he is batting .250 with two home runs, a walk and four RBIs.

Reds Player Leaders

• Elly De La Cruz has racked up a team-high OBP (.360) and slugging percentage (.525), and leads the Reds in hits (54, while batting .298).
• Including all the qualified hitters in the majors, he is 21st in batting average, 45th in on-base percentage and 17th in slugging percentage.
• De La Cruz hopes to build on an eight-game hitting streak in this matchup. During his last 10 games he is hitting .341 with five doubles and five RBIs.
• Sal Stewart has eight doubles, 10 home runs and 23 walks while hitting .238. He's slugging .459 with an on-base percentage of .325.
• He is currently 105th in batting average, 97th in on-base percentage and 51st in slugging percentage among all qualifying hitters.
• Spencer Steer is hitting .263 with seven doubles, seven home runs and 14 walks.
• Matt McLain has eight doubles, five home runs and 23 walks while hitting .217.

Guardians vs Reds Head to Head

• 5/15/2026: 7-6 CIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/11/2025: 11-2 CLE (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/10/2025: 1-0 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 7-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 5/18/2025: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/17/2025: 4-1 CIN (Favorite: Guardians, Spread: -1.5, Total: 10, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/16/2025: 5-4 CIN (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/25/2024: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/24/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/12/2024: 4-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!