Guardians vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for April 28

Odds updated as of 6:13 p.m.

The Tuesday slate in MLB includes a matchup between the Cleveland Guardians and the Tampa Bay Rays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Guardians vs Rays Game Info

• Cleveland Guardians (15-15) vs. Tampa Bay Rays (17-11)
• Date: Tuesday, April 28, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Rays.TV

Guardians vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | TB: (+110)
• Spread: CLE: -1.5 (+155) | TB: +1.5 (-188)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Guardians vs Rays Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 0-3, 4.45 ERA vs Nick Martínez (Rays) - 1-1, 2.10 ERA

The Guardians will give the nod to Tanner Bibee (0-3) against the Rays and Nick Martinez (1-1). When Bibee starts, his team is 1-5-0 against the spread this season. Bibee has started three games with his team as the moneyline favorite, and has been upset each time. The Rays have a 4-1-0 record against the spread in Martínez's starts. The Rays are 3-1 in Martínez's four starts this season that they were the moneyline underdog.

Guardians vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (55.5%)

Guardians vs Rays Moneyline

• Tampa Bay is a +110 underdog on the moneyline, while Cleveland is a -130 favorite at home.

Guardians vs Rays Spread

• The Rays are at +1.5 on the runline against the Guardians. The Rays are -188 to cover the spread, and the Guardians are +155.

Guardians vs Rays Over/Under

• The Guardians-Rays game on April 28 has been given an over/under of 7.5 runs. The over is set at -112 and the under at -108.

Bet on Cleveland Guardians vs. Tampa Bay Rays on FanDuel today!

Guardians vs Rays Betting Trends

• The Guardians have been victorious in seven, or 53.8%, of the 13 contests they have been chosen as favorites in this season.
• Cleveland has a record of 3-4 when favored by -130 or more this year.
• The Guardians and their opponents have gone over in 15 of their 30 games with a total set by sportsbooks this season.
• In 30 games with a line this season, the Guardians have a mark of 16-14-0 against the spread.
• The Rays have been the underdog on the moneyline 13 total times this season. They've finished 7-6 in those games.
• Tampa Bay is 5-1 (winning 83.3% of its games) when it has played as a moneyline underdog of +110 or longer.
• The Rays have played in 28 games with a set over/under, and have combined with opponents to go over the total 17 times (17-11-0).
• The Rays have a 17-11-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez leads Cleveland OPS (.803) this season. He has a .229 batting average, an on-base percentage of .354, and a slugging percentage of .450.
• Among qualifying batters in MLB, his batting average ranks 125th, his on-base percentage ranks 54th, and he is 60th in slugging.
• Chase DeLauter is hitting .245 with six doubles, a triple, five home runs and 13 walks, while slugging .489 with an on-base percentage of .333.
• Among qualified hitters, he is 84th in batting average, 86th in on-base percentage and 34th in slugging percentage.
• DeLauter brings a three-game streak with at least one hit into this matchup. In his last five games he is batting .353 with a double, a walk and an RBI.
• Brayan Rocchio has an OPS of .750, fueled by an OBP of .352 and a team-best slugging percentage of .398 this season.
• Angel Martinez leads Cleveland in total hits (24) this season while batting .276 with 10 extra-base hits.

Rays Player Leaders

• Yandy Diaz has racked up a team-best OBP (.424) and slugging percentage (.486). He's batting .327.
• He is fifth in batting average, fourth in on-base percentage and 37th in slugging percentage among all qualified hitters in the big leagues.
• Junior Caminero has racked up 29 hits to pace his team. He has a batting average of .259 while slugging .500 with an on-base percentage of .333.
• His batting average is 67th among all qualified players, his on-base percentage ranks 86th, and he is 29th in slugging.
• Jonathan Aranda is hitting .228 with four doubles, seven home runs and 19 walks.
• Chandler Simpson is hitting .309 with two triples and six walks.

Guardians vs Rays Head to Head

• 4/27/2026: 3-2 TB (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2025: 2-1 CLE (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/6/2025: 3-2 CLE (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/5/2025: 7-1 CLE (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/4/2025: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)

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