Guardians vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for April 18

Odds updated as of 6:11 p.m.

The Cleveland Guardians are among the MLB squads playing on Friday, versus the Pittsburgh Pirates.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Pirates Game Info

• Cleveland Guardians (9-9) vs. Pittsburgh Pirates (8-12)
• Date: Friday, April 18, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and CLEG

Guardians vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-130) | PIT: (+110)
• Spread: CLE: -1.5 (+128) | PIT: +1.5 (-154)
• Total: 8.5 -- Over: (-128) | Under: (+104)

Guardians vs Pirates Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 1-2, 6.06 ERA vs Carmen Mlodzinski (Pirates) - 1-2, 6.23 ERA

The Guardians will give the nod to Luis Ortiz (1-2) versus the Pirates and Carmen Mlodzinski (1-2). Ortiz and his team have a record of 1-2-0 against the spread when he starts. Ortiz's team is 1-1 this season when he starts and they're favored on the moneyline. The Pirates are 1-2-0 ATS in Mlodzinski's three starts with a set spread. The Pirates are 1-2 in Mlodzinski's three starts this season that they were the moneyline underdog.

Guardians vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.4%)

Guardians vs Pirates Moneyline

• The moneyline numbers for Guardians vs. Pirates reveal Cleveland as the favorite (-130) and Pittsburgh as the underdog (+110) despite being the home team.

Guardians vs Pirates Spread

• The Pirates are +1.5 on the spread (-154 to cover), and Cleveland is +128 to cover the runline.

Guardians vs Pirates Over/Under

• The over/under for the Guardians versus Pirates game on April 18 has been set at 8.5, with -128 odds on the over and +104 odds on the under.

Bet on Cleveland Guardians vs. Pittsburgh Pirates on FanDuel today!

Guardians vs Pirates Betting Trends

• The Guardians have come away with six wins in the eight contests they have been listed as the favorites in this season.
• This year Cleveland has won four of five games when listed as at least -130 on the moneyline.
• The Guardians' games have gone over the total in nine of their 18 opportunities.
• The Guardians are 7-11-0 against the spread in their 18 games that had a posted line this season.
• The Pirates have put together a 3-8 record in games they were listed as the moneyline underdog (winning 27.3% of those games).
• When it has played as a moneyline underdog with odds of +110 or longer, Pittsburgh has a 1-6 record (winning only 14.3% of its games).
• In the 20 games oddsmakers have set an over/under for the Pirates, they have combined with opponents to go over the total eight times (8-11-1).
• The Pirates have collected a 6-14-0 record ATS this season.

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.814) this season. He has a .310 batting average, an on-base percentage of .364, and a slugging percentage of .451.
• Among all qualifying hitters in baseball, he ranks 25th in batting average, 47th in on-base percentage, and 61st in slugging.
• Jose Ramirez leads Cleveland with 15 hits. He is batting .250 this season and has seven extra-base hits. He's also slugging .500 with an on-base percentage of .314.
• Among all qualifying players, he ranks 82nd in batting average, 94th in on-base percentage and 39th in slugging percentage.
• Kyle Manzardo is batting .185 with a .463 slugging percentage and 11 RBI this year.
• Carlos Santana is batting .261 with a .325 OBP and five RBI for Cleveland this season.
• Santana has hit safely in four straight games. During his last five outings he is hitting .238 with .

Pirates Player Leaders

• Oneil Cruz has put up a team-best OBP (.352), while pacing the Pirates in hits (13). He's batting .228 and slugging.
• Including all qualified hitters, he ranks 100th in batting average, while his on-base percentage ranks 54th and he is 50th in slugging.
• Ke'Bryan Hayes is batting .194 with a double, a triple, a home run and seven walks. He's slugging .284 with an on-base percentage of .270.
• His batting average is 134th among all qualified players, his on-base percentage is 134th, and he is 146th in slugging.
• Isiah Kiner-Falefa has a .317 slugging percentage, which leads the Pirates.
• Andrew McCutchen is hitting .233 with two doubles, a home run and seven walks.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!