Astros vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for April 19

Odds updated as of 10:12 a.m.

The Houston Astros versus the San Diego Padres is on the MLB schedule for Saturday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Astros vs Padres Game Info

• Houston Astros (9-10) vs. San Diego Padres (15-5)
• Date: Saturday, April 19, 2025
• Time: 7:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: Fox Sports 1, SCHN, and SDPA

Astros vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-162) | SD: (+136)
• Spread: HOU: -1.5 (+130) | SD: +1.5 (-156)
• Total: 9 -- Over: (-102) | Under: (-120)

Astros vs Padres Probable Starting Pitchers

Probable Pitchers: Hayden Wesneski (Astros) - 1-1, 4.00 ERA vs Michael King (Padres) - 3-0, 2.42 ERA

The Astros will give the nod to Hayden Wesneski (1-1, 4.00 ERA), who is eyeing win No. 2 on the season, and the Padres will turn to Michael King (3-0, 2.42 ERA). When Wesneski starts, his team is 2-1-0 against the spread this season. Wesneski's team won his only start as a favorite this season. When King starts, the Padres are 3-1-0 against the spread. The Padres were named the moneyline underdog for one King start this season -- they won.

Astros vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.9%)

Astros vs Padres Moneyline

• San Diego is the underdog, +136 on the moneyline, while Houston is a -162 favorite at home.

Astros vs Padres Spread

• The Padres are at +1.5 on the runline against the Astros. The Padres are -156 to cover the spread, and the Astros are +130.

Astros vs Padres Over/Under

• The Astros-Padres game on April 19 has been given an over/under of 9 runs. The over is set at -102 and the under at -120.

Bet on Houston Astros vs. San Diego Padres on FanDuel today!

Astros vs Padres Betting Trends

• The Astros have been favorites in 12 games this season and have come away with the win six times (50%) in those contests.
• This season Houston has been victorious two times in four chances when named as a favorite of at least -162 on the moneyline.
• The Astros and their opponents have gone over the total this season in eight of their 19 opportunities.
• The Astros have posted a record of 9-10-0 against the spread this season.
• The Padres have won 50% of the games this season they were the underdog on the moneyline (4-4).
• San Diego has played as a moneyline underdog of +136 or longer in only one game this season, which it lost.
• The Padres have combined with opponents to go over the total nine times this season for a 9-10-1 record against the over/under.
• The Padres have covered 70% of their games this season, going 14-6-0 ATS.

Astros Player Leaders

• Jose Carlos Altuve has 25 hits and an OBP of .349 to go with a slugging percentage of .449. All three of those stats rank first among Houston hitters this season. He has a .321 batting average, as well.
• He ranks 16th in batting average, 57th in on-base percentage, and 64th in slugging among all qualifying batters in MLB.
• Altuve has hit safely in three games in a row. In his last five games he is batting .278 with a double and an RBI.
• Jeremy Pena is hitting .221 with two doubles, three home runs and seven walks, while slugging .382 with an on-base percentage of .308.
• He ranks 108th in batting average, 101st in on-base percentage and 94th in slugging in the majors.
• Pena takes a nine-game streak with at least one hit into this one. In his last 10 games he is hitting .270 with two doubles, a home run, five walks and five RBI.
• Isaac Paredes is batting .222 with a .361 slugging percentage and 10 RBI this year.
• Jake Meyers is batting .308 with a .362 OBP and five RBI for Houston this season.

Padres Player Leaders

• Fernando Tatis Jr. has accumulated an on-base percentage of .424, a slugging percentage of .603, and has 25 hits, all club-bests for the Padres (while batting .342).
• He is ninth in batting average, 10th in on-base percentage and 12th in slugging percentage among all qualifying hitters in the majors.
• Tatis hopes to build on a seven-game hitting streak in this matchup. During his last 10 outings he is hitting .282 with five home runs, seven walks and eight RBI.
• Manny Machado has eight doubles, two home runs and eight walks while hitting .307. He's slugging .493 with an on-base percentage of .373.
• He is 30th in batting average, 40th in on-base percentage and 43rd in slugging percentage in the majors.
• Luis Sangel (Reveron) Arraez has a .435 slugging percentage, which paces the Padres.
• Xander Bogaerts is batting .257 with seven doubles and 10 walks.

Astros vs Padres Head to Head

• 4/18/2025: 6-4 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/18/2024: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 6.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/17/2024: 4-3 HOU (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/16/2024: 3-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/10/2023: 12-2 HOU (Favorite: Astros, Spread: -1.5, Total: 10, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 9/9/2023: 7-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/8/2023: 11-2 SD (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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