Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 1:12 a.m.

The MLB's Monday schedule includes the Cleveland Guardians facing the Washington Nationals.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Nationals Game Info

• Cleveland Guardians (32-23) vs. Washington Nationals (27-27)
• Date: Monday, May 25, 2026
• Time: 6:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Nationals.TV

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-174) | WSH: (+146)
• Spread: CLE: -1.5 (+125) | WSH: +1.5 (-150)
• Total: 8.5 -- Over: (+100) | Under: (-122)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 0-6, 3.75 ERA vs Zack Littell (Nationals) - 3-4, 5.83 ERA

The Guardians will give the nod to Tanner Bibee (0-6) against the Nationals and Zack Littell (3-4). Bibee and his team have a record of 1-9-0 against the spread when he starts. When Bibee starts a game and his team is the favorite on the moneyline, they have a record of 1-5. The Nationals have a 4-3-0 ATS record in Littell's seven starts with a set spread. The Nationals have been the underdog on the moneyline in seven of Littell's starts this season, and they went 4-3 in those games.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (60.6%)

Guardians vs Nationals Moneyline

• Washington is the underdog, +146 on the moneyline, while Cleveland is a -174 favorite at home.

Guardians vs Nationals Spread

• The Guardians are hosting the Nationals and are favored by 1.5 runs (+125 to cover) on the runline. Washington is -150 to cover.

Guardians vs Nationals Over/Under

• An over/under of 8.5 has been set for Guardians-Nationals on May 25, with the over being +100 and the under -122.

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Guardians vs Nationals Betting Trends

• The Guardians have been chosen as favorites in 28 games this year and have walked away with the win 17 times (60.7%) in those games.
• Cleveland has played as a favorite of -174 or more just one time this year and came away with a win in that game.
• The Guardians and their opponents have gone over the total this season in 25 of their 51 opportunities.
• In 51 games with a line this season, the Guardians have a mark of 28-23-0 against the spread.
• The Nationals have a 25-26 record in games they were the underdog on the moneyline (winning 49% of those games).
• When it has played as a moneyline underdog with odds of +146 or longer, Washington has a record of 7-9 (43.8%).
• The Nationals have played in 54 games with an over/under set, and have combined with their opponents to go over the total 33 times (33-18-3).
• The Nationals have covered 61.1% of their games this season, going 33-21-0 ATS.

Guardians Player Leaders

• Jose Ramirez has 11 doubles, eight home runs and 37 walks while hitting .227. He has an on-base percentage of .347 and a slugging percentage of .399.
• He is 122nd in batting average, 62nd in on-base percentage, and 89th in slugging among all qualifying batters in baseball.
• Chase DeLauter has 11 doubles, a triple, seven home runs and 25 walks. He's batting .261 and slugging .450 with an on-base percentage of .348.
• His batting average ranks 66th among qualified players, his on-base percentage 58th, and his slugging percentage 53rd.
• Brayan Rocchio has a team-best OPS of .781, fueled by a slash line of .286/.370/.411 this season.
• Angel Martinez has 41 hits, which ranks first among Cleveland hitters this season, while batting .246 with 18 extra-base hits.

Nationals Player Leaders

• C.J. Abrams has collected 56 hits, a team-high for the Nationals. He's batting .289 and slugging .536 with an on-base percentage of .382.
• Including all qualifying players, he ranks 27th in batting average, while his on-base percentage is 19th and he is 13th in slugging.
• James Wood's .398 OBP paces his team. He has a batting average of .254 while slugging .512.
• He ranks 77th in batting average, 10th in on-base percentage and 20th in slugging percentage in the big leagues.
• Daylen Lile has a slugging percentage of .444, a team-high for the Nationals.
• Jacob Young is hitting .231 with six doubles, six home runs and nine walks.

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