Guardians vs Blue Jays Prediction, Odds, Moneyline, Spread & Over/Under for June 25

Odds updated as of 7:11 a.m.

MLB action on Wednesday includes the Cleveland Guardians taking on the Toronto Blue Jays.

All the info you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Blue Jays Game Info

• Cleveland Guardians (39-38) vs. Toronto Blue Jays (42-36)
• Date: Wednesday, June 25, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and SNET

Guardians vs Blue Jays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-112) | TOR: (-104)
• Spread: CLE: +1.5 (-182) | TOR: -1.5 (+150)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Guardians vs Blue Jays Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 5-3, 3.58 ERA vs Max Scherzer (Blue Jays) - 0-0, 6.00 ERA

The Guardians will give the ball to Gavin Williams (5-3, 3.58 ERA), who is eyeing win No. 6 on the season, and the Blue Jays will turn to Max Scherzer. Williams and his team have a record of 8-7-0 against the spread when he starts. Williams' team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 3-2. Scherzer has started just one game with a set spread, which the Blue Jays failed to cover. The Blue Jays have not been a moneyline underdog when Scherzer starts this season.

Guardians vs Blue Jays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (52.4%)

Guardians vs Blue Jays Moneyline

• Cleveland is the favorite, -112 on the moneyline, while Toronto is a -104 underdog on the road.

Guardians vs Blue Jays Spread

• The Blue Jays are 1.5-run favorites against the spread for this matchup with the Guardians. The Blue Jays are +150 to cover, while the Guardians are -182 to cover as a 1.5-run underdog on the runline.

Guardians vs Blue Jays Over/Under

• A combined run total of 8.5 has been set for Guardians-Blue Jays on June 25, with the over at -104 and the under at -118.

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Guardians vs Blue Jays Betting Trends

• The Guardians have been chosen as favorites in 26 games this year and have walked away with the win 16 times (61.5%) in those games.
• This season Cleveland has come away with a win 16 times in 26 chances when named as a favorite of at least -112 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 32 of their 75 opportunities.
• The Guardians are 38-37-0 against the spread in their 75 games that had a posted line this season.
• The Blue Jays have put together a 23-23 record in games they were listed as the moneyline underdog (winning 50% of those games).
• Toronto has a 20-21 record (winning 48.8% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Blue Jays have had an over/under set by oddsmakers 77 times, and have combined with opponents to go over the total in 41 of those games (41-33-3).
• The Blue Jays have put together a 46-31-0 record ATS this season.

Guardians Player Leaders

• Jose Ramirez has 90 hits and an OBP of .377 to go with a slugging percentage of .518. All three of those stats rank first among Cleveland hitters this season. He has a .317 batting average, as well.
• Among qualifying hitters in baseball, he is seventh in batting average, 19th in on-base percentage, and 16th in slugging.
• Steven Kwan is batting .310 with 17 doubles, six home runs and 26 walks. He's slugging .432 with an on-base percentage of .371.
• Among qualifying hitters, he is ninth in batting average, 24th in on-base percentage and 72nd in slugging percentage.
• Kwan enters this game looking to extend his five-game hit streak. During his last five outings he is hitting .524 with three doubles, a walk and an RBI.
• Carlos Santana has collected 61 base hits, an OBP of .333 and a slugging percentage of .370 this season.
• Kyle Manzardo is batting .220 with a .298 OBP and 32 RBI for Cleveland this season.
• Manzardo takes a three-game hitting streak into this game. During his last five outings he is hitting .400 with three doubles, a home run, a walk and an RBI.

Blue Jays Player Leaders

• Vladimir Guerrero Jr. has accumulated an on-base percentage of .383, a team-high for the Blue Jays. He's batting .281 and slugging .441.
• Including all the qualified hitters in the big leagues, he is 39th in batting average, 15th in on-base percentage and 65th in slugging percentage.
• Bo Bichette's .440 slugging percentage paces his team. He has a batting average of .277 with an on-base percentage of .318.
• Including all qualified players, he ranks 47th in batting average, 102nd in on-base percentage and 67th in slugging percentage.
• George Springer has 61 hits, a team-high for the Blue Jays.
• Alejandro Kirk is hitting .309 with eight doubles, seven home runs and 16 walks.

Guardians vs Blue Jays Head to Head

• 6/24/2025: 10-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/4/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/3/2025: 5-3 CLE (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 5/2/2025: 5-3 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/23/2024: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/22/2024: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/21/2024: 7-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/16/2024: 7-6 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/15/2024: 5-0 TOR (Favorite: Blue Jays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/14/2024: 3-1 CLE (Favorite: Blue Jays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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