Giants vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 8

Odds updated as of 6:12 a.m.

In MLB action on Tuesday, the San Francisco Giants play the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Giants vs Cardinals Game Info

• San Francisco Giants (60-85) vs. St. Louis Cardinals (72-73)
• Date: Tuesday, September 8, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Cardinals.TV

Giants vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-112) | STL: (-104)
• Spread: SF: +1.5 (-178) | STL: -1.5 (+146)
• Total: 8 -- Over: (-105) | Under: (-115)

Giants vs Cardinals Probable Starting Pitchers

Probable Pitchers: Landen Roupp (Giants) - 8-13, 4.17 ERA vs Quinn Mathews (Cardinals) - 1-2, 4.38 ERA

The Giants will call on Landen Roupp (8-13) versus the Cardinals and Quinn Mathews (1-2). Roupp's team is 9-18-0 against the spread this season in his starts. Roupp's team is 1-7 this season when he starts and they are the moneyline favorite. The Cardinals have gone 2-3-0 ATS in Mathews' five starts with a set spread. The Cardinals are 1-3 in Mathews' four starts this season that they were the moneyline underdog.

Giants vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (52.5%)

Giants vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Giants, St. Louis is the underdog at -104, and San Francisco is -112 playing at home.

Giants vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Giants. The Cardinals are +146 to cover, while the Giants are -178 to cover as a 1.5-run underdog on the runline.

Giants vs Cardinals Over/Under

• The over/under for the Giants versus Cardinals game on Sept. 8 has been set at 8, with -105 odds on the over and -115 odds on the under.

Bet on San Francisco Giants vs. St. Louis Cardinals on FanDuel today!

Giants vs Cardinals Betting Trends

• The Giants have been victorious in 21, or 46.7%, of the 45 contests they have been chosen as favorites in this season.
• San Francisco has a record of 20-20 when favored by -112 or more this year.
• The Giants' games have gone over the total in 68 of their 142 opportunities.
• The Giants have posted a record of 67-75-0 against the spread this season.
• The Cardinals have a 44-51 record in games they were the underdog on the moneyline (winning 46.3% of those games).
• In games it has played as a moneyline underdog with odds of -104 or longer, St. Louis has a 40-46 record (winning 46.5% of its games).
• The Cardinals have had an over/under set by oddsmakers 141 times, and have combined with opponents to go over the total in 64 of those games (64-70-7).
• The Cardinals have collected a 77-64-0 record against the spread this season (covering 54.6% of the time).

Giants Player Leaders

• Rafael Devers has 142 hits and an OBP of .342 to go with a slugging percentage of .522. All three of those stats are best among San Francisco hitters this season. He has a .260 batting average, as well.
• Among qualified hitters, he is 62nd in batting average, his on-base percentage ranks 51st, and he is ninth in slugging.
• Devers has recorded a base hit in four straight games. During his last five outings he is hitting .421 with four doubles, three home runs, three walks and nine RBIs.
• Jung Hoo Lee is batting .280 with 28 doubles, four triples, nine home runs and 27 walks, while slugging .406 with an on-base percentage of .323.
• He is 25th in batting average, 83rd in on-base percentage and 86th in slugging in the majors.
• Lee takes a two-game streak with at least one hit into this contest. During his last five outings he is hitting .150 with a double, a walk and three RBIs.
• Bryce Eldridge has 94 hits this season and has a slash line of .265/.359/.451.
• Eldridge has logged a hit or more in four games in a row. During his last five outings he is hitting .294 with three doubles, four walks and three RBIs.
• Drew Gilbert has eight home runs, 36 RBI and a batting average of .231 this season.

Cardinals Player Leaders

• Alec Burleson is hitting .283 with 34 doubles, a triple, 22 home runs and 48 walks. He's slugging .467 with an on-base percentage of .344.
• Including all the qualified hitters in the big leagues, his batting average puts him 16th, his on-base percentage ranks 47th, and he is 34th in slugging.
• Burleson hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .273 with a double, a home run and three RBIs.
• Jordan Walker paces his team with 157 hits and has a club-high .494 slugging percentage. He has a batting average of .284 with an on-base percentage of .340.
• His batting average ranks 14th among all qualified players, his on-base percentage is 52nd, and he is 16th in slugging.
• Ivan Herrera a has .362 on-base percentage to pace the Cardinals.
• Nathan Church is batting .243 with 12 doubles, two triples, 10 home runs and 21 walks.

Giants vs Cardinals Head to Head

• 9/7/2026: 5-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 9/24/2025: 4-3 SF (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/23/2025: 9-8 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/22/2025: 6-5 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/7/2025: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/6/2025: 3-2 STL (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 9/5/2025: 8-2 SF (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 6-1 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/28/2024: 6-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 6-3 STL (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)

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