Cubs vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 4:11 a.m.

The MLB slate on Saturday includes the Chicago Cubs taking on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Cubs vs White Sox Game Info

• Chicago Cubs (29-16) vs. Chicago White Sox (22-22)
• Date: Saturday, May 16, 2026
• Time: 7:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MARQ

Cubs vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-112) | CHW: (-104)
• Spread: CHC: -1.5 (+150) | CHW: +1.5 (-182)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Cubs vs White Sox Probable Starting Pitchers

Probable Pitchers: Jameson Taillon (Cubs) - 2-2, 3.94 ERA vs Davis Martin (White Sox) - 5-1, 1.62 ERA

This contest's pitching matchup is set, as the Cubs will send Jameson Taillon (2-2) to the mound, while Davis Martin (5-1) will answer the bell for the White Sox. Taillon's team is 2-6-0 against the spread in his starts this season. When Taillon starts a game and his team is the favorite on the moneyline, they have a record of 3-1. The White Sox are 7-1-0 against the spread when Martin starts. The White Sox are 7-1 in Martin's eight starts this season that they were the moneyline underdog.

Cubs vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (55.7%)

Cubs vs White Sox Moneyline

• The Cubs vs White Sox moneyline has the Cubs as a -112 favorite, while the White Sox are a -104 underdog at home.

Cubs vs White Sox Spread

• The Cubs are 1.5-run favorites on the runline against the White Sox. The Cubs are +150 to cover, while the White Sox are -182 to cover.

Cubs vs White Sox Over/Under

• The over/under for Cubs-White Sox on May 16 is 8.5. The over is -118, and the under is -104.

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Cubs vs White Sox Betting Trends

• The Cubs have been favorites in 29 games this season and have come away with the win 20 times (69%) in those contests.
• This season, the Cubs have come away with a win 19 times in 28 chances when named as a favorite of at least -112 or better on the moneyline.
• The Cubs and their opponents have hit the over in 25 of their 44 games with a total this season.
• In 44 games with a line this season, the Cubs have a mark of 21-23-0 against the spread.
• The White Sox have been the moneyline underdog 38 total times this season. They've gone 19-19 in those games.
• The White Sox have a record of 18-19 when playing as a moneyline underdog with odds of -104 or longer (48.6%).
• The White Sox have combined with their opponents to hit the over on the total 23 times this season for a 23-19-0 record against the over/under.
• The White Sox have covered 57.1% of their games this season, going 24-18-0 ATS.

Cubs Player Leaders

• Nico Hoerner leads Chicago with a slugging percentage of .399, fueled by 16 extra-base hits. He has a .264 batting average and an on-base percentage of .340.
• Among qualifying hitters in the majors, his batting average ranks 64th, his on-base percentage ranks 74th, and he is 85th in slugging.
• Ian Happ leads the Cubs in OBP (.381) and total hits (38) this season. He's batting .241 while slugging .481.
• He is 101st in batting average, 19th in on-base percentage and 37th in slugging among qualified batters.
• Happ enters this game looking to extend his two-game hit streak. During his last five outings he is batting .267 with a home run, five walks and two RBIs.
• Dansby Swanson has 28 hits this season and has a slash line of .189/.297/.351.
• Alex Bregman is batting .250 with a .338 OBP and 14 RBI for Chicago this season.
• Bregman has hit safely in six straight games. In his last 10 games he is hitting .275 with a double, a home run, five walks and two RBIs.

White Sox Player Leaders

• Miguel Vargas a has .376 on-base percentage to pace the White Sox. He's batting .247 while slugging .494.
• Including all qualified players in the majors, his batting average places him 91st, his on-base percentage is 28th, and he is 29th in slugging.
• Vargas hopes to build on a seven-game hitting streak in this matchup. In his last 10 games he is batting .333 with two doubles, four home runs, six walks and seven RBIs.
• Munetaka Murakami's 35 hits lead his team. He has a batting average of .227 while slugging .526 with an on-base percentage of .368.
• He is currently 121st in batting average, 38th in on-base percentage and 16th in slugging percentage among all qualifying hitters.
• Colson Montgomery has eight doubles, 12 home runs and 16 walks while hitting .237.
• Chase Meidroth paces his team with a .394 slugging percentage.

Cubs vs White Sox Head to Head

• 5/15/2026: 10-5 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/27/2025: 5-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/26/2025: 6-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/25/2025: 12-5 CHW (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -186, Underdog Moneyline: +156)
• 5/18/2025: 6-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 5/17/2025: 7-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 10, Favorite Moneyline: -310, Underdog Moneyline: +250)
• 5/16/2025: 13-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 11.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/10/2024: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 8/9/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/5/2024: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -200, Underdog Moneyline: +168)

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