Cubs vs Royals Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 9:11 a.m.

The MLB slate on Tuesday includes the Chicago Cubs taking on the Kansas City Royals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Royals Game Info

• Chicago Cubs (59-41) vs. Kansas City Royals (49-52)
• Date: Tuesday, July 22, 2025
• Time: 8:05 p.m. ET
• Venue: Wrigley Field -- Chicago, Illinois
• Coverage: MARQ and FDSKC

Cubs vs Royals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-250) | KC: (+205)
• Spread: CHC: -1.5 (-122) | KC: +1.5 (+102)
• Total: 9 -- Over: (-105) | Under: (-115)

Cubs vs Royals Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 10-3, 2.34 ERA vs Richard Hill (Royals) - 0-0, 0.00 ERA

The Cubs will give the ball to Matthew Boyd (10-3, 2.34 ERA), who is eyeing win No. 11 on the season, and the Royals will counter with Richard Hill. Boyd's team is 8-10-0 against the spread in his starts this season. Boyd's team is 9-3 this season when he starts and they are the moneyline favorite. Hill did not pitch as a moneyline underdog a season ago.

Cubs vs Royals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (65.7%)

Cubs vs Royals Moneyline

• The Cubs vs Royals moneyline has Chicago as a -250 favorite, while Kansas City is a +205 underdog on the road.

Cubs vs Royals Spread

• The Royals are +1.5 on the spread (+102 to cover), and Chicago is -122 to cover the runline.

Cubs vs Royals Over/Under

• The over/under for Cubs-Royals on July 22 is 9. The over is -105, and the under is -115.

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Cubs vs Royals Betting Trends

• The Cubs have been victorious in 44, or 69.8%, of the 63 contests they have been chosen as favorites in this season.
• Chicago has not lost in seven games when named as a moneyline favorite of -250 or better.
• The Cubs and their opponents have gone over in 49 of their 97 games with a total set by sportsbooks this season.
• The Cubs have posted a record of 48-49-0 against the spread this season.
• The Royals have won 47.5% of the games this season they were the underdog on the moneyline (29-32).
• Kansas City has not played a game this season with moneyline odds of +205 or longer.
• In the 99 games bookmakers have set an over/under for the Royals, they have combined with opponents to go over the total 39 times (39-58-2).
• The Royals have put together a 50-49-0 record ATS this season.

Cubs Player Leaders

• Kyle Tucker leads Chicago in OBP (.382) this season, fueled by 102 hits. He has a .276 batting average and a slugging percentage of .496.
• Among the qualified batters in baseball, his batting average ranks 44th, his on-base percentage ranks ninth, and he is 23rd in slugging.
• Pete Crow-Armstrong leads Chicago in slugging percentage (.556) and total hits (104) this season. He's batting .270 with an on-base percentage of .306.
• His batting average is 55th among qualified players, his on-base percentage 124th, and his slugging percentage eighth.
• Crow-Armstrong has picked up at least one hit in four games in a row. In his last five games he is hitting .286 with three doubles, a home run and two RBIs.
• Seiya Suzuki is batting .258 with a .539 slugging percentage and 80 RBI this year.
• Nico Hoerner leads Chicago in slugging percentage (.375) thanks to 24 extra-base hits.

Royals Player Leaders

• Bobby Witt Jr. has 115 hits with a .491 slugging percentage, both team-high figures for the Royals. He's batting .288 and with an on-base percentage of .339.
• Including all the qualifying hitters in MLB, his batting average is 20th, his on-base percentage ranks 62nd, and he is 26th in slugging.
• Maikel Garcia's .347 on-base percentage leads his team. He has a batting average of .293 while slugging .446.
• Including all qualified hitters, his batting average puts him 12th, his on-base percentage is 51st, and he is 63rd in slugging.
• Vinnie Pasquantino is batting .264 with 14 doubles, a triple, 15 home runs and 29 walks.
• Salvador Perez is batting .253 with 26 doubles, 17 home runs and 18 walks.

Cubs vs Royals Head to Head

• 7/21/2025: 12-4 KC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/28/2024: 7-3 CHC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 7/27/2024: 9-4 CHC (Favorite: Royals, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 7/26/2024: 6-0 KC (Favorite: Royals, Spread: -1.5, Total: 9, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/20/2023: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/19/2023: 6-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 8/18/2023: 4-3 KC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -190, Underdog Moneyline: +160)

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