Cubs vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 24

Odds updated as of 2:12 a.m.

MLB action on Saturday includes the Chicago Cubs facing the Cincinnati Reds.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Cubs vs Reds Game Info

• Chicago Cubs (31-20) vs. Cincinnati Reds (25-27)
• Date: Saturday, May 24, 2025
• Time: 4:10 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and MARQ

Cubs vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-124) | CIN: (+106)
• Spread: CHC: -1.5 (+126) | CIN: +1.5 (-152)
• Total: 9 -- Over: (-122) | Under: (-100)

Cubs vs Reds Probable Starting Pitchers

Probable Pitchers: Colin Rea (Cubs) - 3-0, 2.38 ERA vs Andrew Abbott (Reds) - 3-0, 1.80 ERA

The Cubs will call on Colin Rea (3-0) versus the Reds and Andrew Abbott (3-0). Rea and his team have a record of 5-1-0 against the spread when he starts. Rea's team has won 66.7% of his starts when they are favored on the moneyline (2-1). The Reds have a 5-1-0 ATS record in Abbott's six starts with a set spread. The Reds have been the moneyline underdog in three of Abbott's starts this season, and they went 2-1 in those matchups.

Cubs vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (51.8%)

Cubs vs Reds Moneyline

• The moneyline numbers for Cubs vs. Reds reveal Chicago as the favorite (-124) and Cincinnati as the underdog (+106) despite being the home team.

Cubs vs Reds Spread

• The Cubs are 1.5-run road favorites on the runline against the Reds. The Cubs are +126 to cover, and the Reds are -152.

Cubs vs Reds Over/Under

• An over/under of 9 has been set for Cubs-Reds on May 24, with the over being -122 and the under -100.

Bet on Chicago Cubs vs. Cincinnati Reds on FanDuel today!

Cubs vs Reds Betting Trends

• The Cubs have been chosen as favorites in 29 games this year and have walked away with the win 21 times (72.4%) in those games.
• Chicago has a record of 16-7 in contests when sportsbooks favor them by -124 or more on the moneyline.
• Contests with the Cubs have gone over the total set by sportsbooks in 31 of 49 chances this season.
• In 49 games with a line this season, the Cubs have a mark of 26-23-0 against the spread.
• The Reds have been the underdog on the moneyline 27 total times this season. They've gone 12-15 in those games.
• Cincinnati has a 6-9 record (winning 40% of its games) when it has played as a moneyline underdog of +106 or longer.
• In the 50 games bookmakers have set an over/under for the Reds, they have combined with opponents to go over the total 19 times (19-29-2).
• The Reds have collected a 26-24-0 record against the spread this season (covering 52% of the time).

Cubs Player Leaders

• Kyle Tucker has 55 hits this season and a team-best OBP of .383. He has a .276 batting average and a slugging percentage of .543.
• Among the qualifying hitters in baseball, his batting average ranks 48th, his on-base percentage ranks 17th, and he is 15th in slugging.
• Tucker has hit safely in three straight games. During his last five outings he is batting .381 with two home runs, two walks and four RBIs.
• Pete Crow-Armstrong leads Chicago in slugging percentage (.589) and total hits (58) this season. He's batting .287 with an on-base percentage of .319.
• He ranks 31st in batting average, 98th in on-base percentage and fifth in slugging in MLB.
• Seiya Suzuki has 50 hits this season and has a slash line of .262/.316/.550.
• Suzuki brings a four-game hitting streak into this matchup. During his last five outings he is hitting .421 with two doubles, two home runs, three walks and nine RBIs.
• Nico Hoerner is batting .296 with a .338 OBP and 22 RBI for Chicago this season.

Reds Player Leaders

• Elly De La Cruz is batting .241 with eight doubles, eight home runs and 20 walks. He's slugging .399 with an on-base percentage of .314.
• Including all qualified hitters, he ranks 105th in batting average, while his on-base percentage is 103rd and he is 98th in slugging.
• TJ Friedl leads his team with a .397 slugging percentage. He has a batting average of .277 with an on-base percentage of .360.
• Including all qualified hitters, his batting average puts him 45th, his on-base percentage is 42nd, and he is 103rd in slugging.
• Gavin Lux has an on-base percentage of .381 and has 45 hits, both team-high numbers for the Reds.
• Austin Hays has six doubles, a triple, six home runs and seven walks while hitting .320.

Cubs vs Reds Head to Head

• 5/23/2025: 13-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/29/2024: 3-0 CIN (Favorite: Reds, Spread: -1.5, Total: 7, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/28/2024: 3-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/27/2024: 1-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/31/2024: 13-4 CHC (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/30/2024: 6-3 CIN (Favorite: Cubs, Spread: -1.5, Total: 9.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/29/2024: 7-1 CIN (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/9/2024: 4-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 6/8/2024: 4-3 CIN (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 6/7/2024: 3-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!