Astros vs Mariners Prediction, Odds, Moneyline, Spread & Over/Under for May 24

Odds updated as of 2:12 a.m.

The MLB slate on Saturday includes the Houston Astros facing the Seattle Mariners.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Astros vs Mariners Game Info

• Houston Astros (26-25) vs. Seattle Mariners (29-21)
• Date: Saturday, May 24, 2025
• Time: 4:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and ROOT Sports NW

Astros vs Mariners Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-116) | SEA: (-102)
• Spread: HOU: +1.5 (-194) | SEA: -1.5 (+160)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Astros vs Mariners Probable Starting Pitchers

Probable Pitchers: Framber Valdez (Astros) - 3-4, 3.57 ERA vs Bryan Woo (Mariners) - 5-1, 2.65 ERA

The probable pitchers are Framber Valdez (3-4) for the Astros and Bryan Woo (5-1) for the Mariners. Valdez and his team have a record of 4-6-0 against the spread when he starts. Valdez's team has a record of 4-5 this season when he starts and they are the favorite on the moneyline. The Mariners are 5-4-0 ATS in Woo's nine starts with a set spread. The Mariners have been the moneyline underdog in five of Woo's starts this season, and they went 3-2 in those games.

Astros vs Mariners Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.1%)

Astros vs Mariners Moneyline

• Houston is the favorite, -116 on the moneyline, while Seattle is a -102 underdog on the road.

Astros vs Mariners Spread

• The Mariners are 1.5-run favorites against the spread for this matchup with the Astros. The Mariners are +160 to cover, while the Astros are -194 to cover as a 1.5-run underdog on the runline.

Astros vs Mariners Over/Under

• The over/under for Astros-Mariners on May 24 is 8.5. The over is -120, and the under is -102.

Bet on Houston Astros vs. Seattle Mariners on FanDuel today!

Astros vs Mariners Betting Trends

• The Astros have come away with 18 wins in the 34 contests they have been listed as the favorites in this season.
• Houston has a record of 17-15 in contests when bookmakers favor them by -116 or more on the moneyline.
• The Astros and their opponents have gone over the total this season in 21 of their 51 opportunities.
• In 51 games with a line this season, the Astros have a mark of 27-24-0 against the spread.
• The Mariners have been the moneyline underdog 20 total times this season. They've gone 12-8 in those games.
• Seattle has an 11-6 record (winning 64.7% of its games) when it has played as a moneyline underdog of -102 or longer.
• In the 49 games bookmakers have set an over/under for the Mariners, they have combined with opponents to go over the total 27 times (27-20-2).
• The Mariners have a 25-24-0 record against the spread this season (covering 51% of the time).

Astros Player Leaders

• Isaac Paredes leads Houston with 50 hits and an OBP of .374 this season. He has a .267 batting average and a slugging percentage of .487.
• Among all qualified hitters, he is 67th in batting average, his on-base percentage ranks 27th, and he is 35th in slugging.
• Jeremy Pena has an OPS of .796, fueled by an OBP of .358 and a team-best slugging percentage of .438 this season. He's batting .292.
• His batting average ranks 25th among qualified players, his on-base percentage 44th, and his slugging percentage 65th.
• Jake Meyers has collected 47 base hits, an OBP of .369 and a slugging percentage of .428 this season.
• Meyers has recorded a hit in eight straight games. In his last 10 outings he is batting .314 with a double, a home run, three walks and two RBIs.
• Jose Altuve has six home runs, 18 RBI and a batting average of .253 this season.
• Altuve brings a two-game hitting streak into this matchup. In his last five games he is hitting .350 with two home runs, a walk and four RBIs.

Mariners Player Leaders

• Cal Raleigh has accumulated 47 hits with a .593 slugging percentage, both team-best stats for the Mariners. He's batting .258 and with an on-base percentage of .373.
• Including all qualifying hitters in the majors, his batting average puts him 80th, his on-base percentage is 30th, and he is fourth in slugging.
• Raleigh takes a four-game hitting streak into this game. During his last five outings he is batting .350 with two doubles, two home runs, two walks and three RBIs.
• Julio Rodriguez has six doubles, two triples, nine home runs and 18 walks while hitting .230. He's slugging .415 with an on-base percentage of .306.
• He is currently 123rd in batting average, 116th in on-base percentage and 81st in slugging percentage among all qualifying hitters.
• Jorge Polanco has six doubles, 10 home runs and nine walks while hitting .285.
• J.P. Crawford has a .386 OBP to pace his team.

Astros vs Mariners Head to Head

• 5/23/2025: 5-3 SEA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/22/2025: 9-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/9/2025: 7-6 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/8/2025: 2-1 HOU (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/7/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/25/2024: 8-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 9/24/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/23/2024: 6-1 SEA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/21/2024: 6-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/20/2024: 4-2 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!