Giants vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 24

Odds updated as of 4:16 a.m.

The MLB's Saturday slate includes the San Francisco Giants taking on the Washington Nationals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Giants vs Nationals Game Info

• San Francisco Giants (30-21) vs. Washington Nationals (23-28)
• Date: Saturday, May 24, 2025
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and NBCS-BA

Giants vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-136) | WSH: (+116)
• Spread: SF: -1.5 (+126) | WSH: +1.5 (-152)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Giants vs Nationals Probable Starting Pitchers

Probable Pitchers: Kyle Harrison (Giants) - 0-0, 3.38 ERA vs Jake Irvin (Nationals) - 3-1, 3.88 ERA

This contest's pitching matchup is set, as the Giants will send Kyle Harrison to the mound, while Jake Irvin (3-1) will get the nod for the Nationals. In 24 games he pitched with a spread last season, Harrison and his team finished with a 16-8-0 record ATS. Harrison and his team won as favorites in 72.7% of his 11 appearances last season with a moneyline. The Nationals have a 6-4-0 record against the spread in Irvin's starts. The Nationals are 5-5 in Irvin's 10 starts this season that they were the moneyline underdog.

Giants vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (50.8%)

Giants vs Nationals Moneyline

• The Giants vs Nationals moneyline has San Francisco as a -136 favorite, while Washington is a +116 underdog at home.

Giants vs Nationals Spread

• The Nationals are +1.5 on the run line against the Giants. The Nationals are -152 to cover, and the Giants are +126.

Giants vs Nationals Over/Under

• A total of 8.5 runs has been set for the Giants-Nationals game on May 24, with the over available at -110 and the under at -110.

Bet on San Francisco Giants vs. Washington Nationals on FanDuel today!

Giants vs Nationals Betting Trends

• The Giants have been favorites in 32 games this season and have come away with the win 20 times (62.5%) in those contests.
• This season San Francisco has come away with a win 14 times in 19 chances when named as a favorite of at least -136 on the moneyline.
• The Giants and their opponents have gone over the total this season in 27 of their 51 opportunities.
• The Giants are 25-26-0 against the spread in their 51 games with a line set by sportsbooks this season.
• The Nationals have won 52.6% of the games this season they were the underdog on the moneyline (20-18).
• Washington has gone 14-15 in games it has played as a moneyline underdog with odds of +116 or longer (48.3%).
• The Nationals have played in 49 games with a set over/under, and have combined with opponents to go over the total 24 times (24-24-1).
• The Nationals are 26-23-0 against the spread this season.

Giants Player Leaders

• Jung Hoo Lee is batting .282 with 14 doubles, two triples, six home runs and 14 walks. He has an on-base percentage of .330 while slugging .467.
• Among all qualified hitters, he ranks 38th in batting average, his on-base percentage ranks 79th, and he is 48th in slugging.
• Lee will look for his fifth straight game with a hit in this matchup. In his last five games he is hitting .278 with two doubles, three walks and two RBIs.
• Wilmer Flores is batting .257 with two doubles, 10 home runs and 16 walks, while slugging .436 with an on-base percentage of .321.
• He ranks 82nd in batting average, 92nd in on-base percentage and 67th in slugging in the majors.
• Flores has picked up at least one hit in four straight games. During his last five outings he is hitting .211 with two walks and an RBI.
• Heliot Ramos has a team-high 56 hits to go with a slugging percentage of .492.
• Ramos has recorded at least one base hit in eight straight games. In his last 10 games he is batting .350 with a double, two home runs, three walks and seven RBIs.
• Matt Chapman has been key for San Francisco with 39 hits, an OBP of .341 plus a slugging percentage of .410.
• Chapman takes a two-game hitting streak into this game. In his last five games he is hitting .167 with a home run, two walks and an RBI.

Nationals Player Leaders

• James Wood has accumulated a team-high OBP (.382) and slugging percentage (.534). He's batting .285.
• Including all qualifying hitters in MLB, he ranks 33rd in batting average, 19th in on-base percentage and 17th in slugging percentage.
• C.J. Abrams has 46 hits to pace his team. He has a batting average of .303 while slugging .546 with an on-base percentage of .363.
• Including all qualifying players, his batting average puts him 16th, his on-base percentage ranks 40th, and he is 14th in slugging.
• Nathaniel Lowe is hitting .223 with eight doubles, eight home runs and 19 walks.
• Luis Garcia has nine doubles, four home runs and 11 walks while batting .231.

Giants vs Nationals Head to Head

• 5/23/2025: 4-0 SF (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/8/2024: 9-5 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/7/2024: 7-4 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/6/2024: 11-5 WSH (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/5/2024: 4-1 SF (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/10/2024: 7-1 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 4/9/2024: 5-3 WSH (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/8/2024: 8-1 WSH (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/23/2023: 6-1 WSH (Favorite: Giants, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/22/2023: 10-1 WSH (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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